Recovery of thymus function using cultured mast cells: prevention of lethal chronic graft-versus-host disease
Project/Area Number |
15K09643
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kanazawa University |
Principal Investigator |
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Research Collaborator |
ARAKI Raita
KURODA Rie
MASE Shintaro
MAEBA Hideaki
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 慢性GVHD / 肥満細胞 / GVHD / 骨髄移植 / 胸腺 / CIK |
Outline of Final Research Achievements |
Refractory hematological malignancies have been cured by the progress of hematopoietic stem cell transplantation, however graft-versus-host disease (GVHD) is still an obstacle. We have studied the pathophysiology of GVHD using a rodent model to develop new treatments, especially focusing in chronic GVHD probably caused by functional impairments of thymus. In this study, we have indicated that host-typed mast cells are involved in the recovery of thymus function using mast cell deficient mice.
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Report
(4 results)
Research Products
(3 results)
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[Presentation] Prophylactic effects of recombinant thrombomodulin against screlodermatous chronic graft-versus-host disease in a rodent model2017
Author(s)
Toshihiro Fujiki, Rie Kuroda, Hideaki Maeba, Kazuhiro Noguchi, Masaki Fukuda, Shintaro Mase, Raita Araki, Yasuhiro Ikawa, Akihiro Yachie, Masayuki Nagasawa, Ryosei Nishimura
Organizer
59th American society of hematology annual meeting
Related Report
Int'l Joint Research
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