Recovery of thymus function using cultured mast cells: prevention of lethal chronic graft-versus-host disease

• Project/Area Number: 15K09643
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kanazawa University
• Principal Investigator: Nishimura Ryosei 金沢大学, 附属病院, 講師 (50324116)
• Research Collaborator: ARAKI Raita ; KURODA Rie ; MASE Shintaro ; MAEBA Hideaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性GVHD / 肥満細胞 / GVHD / 骨髄移植 / 胸腺 / CIK

Outline of Final Research Achievements

Refractory hematological malignancies have been cured by the progress of hematopoietic stem cell transplantation, however graft-versus-host disease (GVHD) is still an obstacle. We have studied the pathophysiology of GVHD using a rodent model to develop new treatments, especially focusing in chronic GVHD probably caused by functional impairments of thymus. In this study, we have indicated that host-typed mast cells are involved in the recovery of thymus function using mast cell deficient mice.

Research Products

• [Presentation] Prophylactic effects of recombinant thrombomodulin against screlodermatous chronic graft-versus-host disease in a rodent model (2017)
  • Author(s): Toshihiro Fujiki, Rie Kuroda, Hideaki Maeba, Kazuhiro Noguchi, Masaki Fukuda, Shintaro Mase, Raita Araki, Yasuhiro Ikawa, Akihiro Yachie, Masayuki Nagasawa, Ryosei Nishimura
  • Organizer: 59th American society of hematology annual meeting
  • Int'l Joint Research
• [Presentation] Third Party Cytokine-Induced Killer Cells Eliminate Highly Activated T-Cells, Leading to Protect from Murine Lethal Graft-Versus Host Disease (2016)
  • Author(s): Rie Kuroda, Shintaro Mase, Hideaki Maeba, Toshihiro Fujiki, Raita Araki, Yasuhiro Ikawa, Shoichi Koizumi, Akihiro Yachie, Ryosei Nishimura
  • Organizer: 58th American society of hematology annual meeting
  • Place of Presentation: San Diego Convention Center (USA)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] ASH Third-party cytokine-induced killer cells protect from murine lethal graft-versus-host disease (2015)
  • Author(s): Rie Kuroda, Shintaro Mase, Toshihiro Fujiki, Hideaki Maeba, Raita Araki, Yasuhiro Ikawa, Masaki Fukuda, Shoichi Koizumi, Akihiro Yachie, Ryosei Nishimura
  • Organizer: 57th American society of hematology annual meeting
  • Place of Presentation: Orange County Convention Center (USA)
  • Year and Date: 2015-12-05
  • Int'l Joint Research