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The investigation of pathophysiology and biomarkers in subacute sclerosing panencephalitis (SSPE)

Research Project

Project/Area Number 15K09654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYamaguchi University

Principal Investigator

HASEGAWA Shunji  山口大学, 大学院医学系研究科, 教授 (90314806)

Co-Investigator(Kenkyū-buntansha) 大賀 正一  九州大学, 医学研究院, 教授 (60233053)
松重 武志  山口大学, 医学部附属病院, 講師 (60528941)
Research Collaborator ICHIYAMA Takashi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords亜急性硬化性全脳炎 / バイオマーカー / プロテオミクス / トリプトファン代謝 / キノリン酸
Outline of Final Research Achievements

Cerebrospinal fluid (CSF) levels of microtubule-associated protein 2 (MAP2) were higher in the patients with SSPE, compared with control group, but not serum levels. In addition, CSF quinolinic acid (QA) levels were increased in the patients with SSPE. Our results show that there may be relationships between CSF MAP2 or QA levels and conditions of SSPE. They may be involved in the pathophysiology of SSPE, and they may be candidates as biomarkers of SSPE.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2015 Other

All Int'l Joint Research (3 results) Presentation (1 results)

  • [Int'l Joint Research] Hacettepe University/Faculty of Medicine/Department of Pediatric Neurology(トルコ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Hacettepe University Faculty of Medicine/Dr. Sami Ulus Children’s Hospital(トルコ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Banu Anlar/Department of Pediatric Neurology/Hacettepe University Faculty of Medicine(トルコ)

    • Related Report
      2015 Research-status Report
  • [Presentation] 亜急性硬化性全脳炎におけるキヌレニン経路活性化の検討2015

    • Author(s)
      松重武志, 井上裕文, 梶本まどか, 岡 桃子, 長谷川俊史, 大森啓充, 奥野海良人, 滝川 修, 大賀正一
    • Organizer
      第57回日本小児神経学会
    • Place of Presentation
      帝国ホテル大阪 (大阪府大阪市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-08-19  

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