Analysis of pathophysiology of skewed X-chromosome inactivation in female patients with X-linked recessive hereditary disease using iPS cells

• Project/Area Number: 15K09655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: Takada Hidetoshi 九州大学, 医学研究院, 教授 (70294931)
• Co-Investigator(Kenkyū-buntansha): 石村 匡崇 九州大学, 医学研究院, 助教 (10448417) ; 田中 珠美 九州大学, 医学研究院, 学術研究員 (60423547)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: X染色体不活化 / X連鎖劣性遺伝性疾患 / X連鎖無ガンマグロブリン血症 / Wiskott-Aldrich症候群 / iPS細胞

Outline of Final Research Achievements

This study was to identify the mechanism of skewed X chromosome inactivation (XCI) which was observed in female XLA and WAS, and to search the drug to treat abnormal XIC. We established a gene transduction method to induce 2 genes which emit 2 different types of fluorescence into iPS cells. By using this system, we could identify the type of XCI by flowcytometer and we found that this system was useful in drug screening. We established the HD.AdAAV gene editing system in which we could induce fatal gene mutation at specific sites, which we found useful in drug-screening. To analyze the mechanism of XCI skewing, we performed whole exon sequencing and genetic analysis of XCI region. We are now working on whole-genome sequencing.

Research Products

• [Journal Article] Nontuberculous mycobacteria-associated hemophagocytic lymphohistiocytosis in MonoMAC syndrome. (2018)
  • Author(s): Eguchi K, Ishimura M, Sonoda M, Ono H, Shiraishi A, Kanno S, Koga Y, Takada H, Ohga S.
  • Journal Title: Pediatr Blood Cancer Volume: Mar 1 Issue: 7 Pages: 1-3
  • DOI: 10.1002/pbc.27017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flow cytometry-based diagnosis of primary immunodeficiency diseases (2018)
  • Author(s): Kanegane H, Hoshino A, Okano T, Yasumi T, Wada T, Takada H, Okada S, Yamashita M, Yeh TW, Nishikomori R, Takagi M, Imai K, Ochs HD, Morio T.
  • Journal Title: Allergology International Volume: 67 Issue: 1 Pages: 43-54
  • DOI: 10.1016/j.alit.2017.06.003
  • NAID: 130006322088
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clarithromycin Plus Intravenous Immunoglobulin Therapy Can Reduce the Relapse Rate of Kawasaki Disease: A Phase 2, Open-Label, Randomized Control Study. (2017)
  • Author(s): Nanishi E, Nishio H, Takada H, Yamamura K, Fukazawa M, Furuno K, Mizuno Y, Saigo K, Kadoya R, Ohbuchi N, Onoe Y, Yamashita H, Nakayama H, Hara T, Ohno T, Takahashi Y, Hatae K, Harada T, Shimose T, Kishimoto J, Ohga S, Hara T.
  • Journal Title: J Am Heart Assoc Volume: 6 Issue: 7
  • DOI: 10.1161/jaha.116.005370
  • Peer Reviewed
• [Journal Article] Long-term safety and efficacy of canakinumab in cryopyrin-associated periodic syndrome: results from an open-label, phase III pivotal study in Japanese patients. (2017)
  • Author(s): Yokota S, Imagawa T, Nishikomori R, Takada H, Abrams K, Lheritier K, Heike T, Hara T.
  • Journal Title: Clin Exp Rheumatol Volume: Nov-Dec;35 Suppl 108(6) Pages: 19-26
  • Peer Reviewed
• [Journal Article] Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease (2017)
  • Author(s): Murata K.、Motomura Y.、Tanaka T.、Kanno S.、Yano T.、Onimaru M.、Shimoyama A.、Nishio H.、Sakai Y.、Oh-Hora M.、Hara H.、Fukase K.、Takada H.、Masuda S.、Ohga S.、Yamasaki S.、Hara T.
  • Journal Title: Clinical & Experimental Immunology Volume: 190 Issue: 1 Pages: 54-67
  • DOI: 10.1111/cei.13002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A CD57+ CTL degranulation assay effectively identifies familial hemophagocytic lymphohistiocytosis type 3 patients (2017)
  • Author(s): Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, Eitaro Hiejima, Hirotsugu Oda, Kazushi Izawa, Tomoki Kawai, Masataka Ishimura, Naoko Nakano, Ryutaro Shirakawa, Ryuta Nishikomori, Hidetoshi Takada, Satoshi Morita, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, and Toshio Heike
  • Journal Title: Journal of Clinical Immunology Volume: 37 Issue: 1 Pages: 92-99
  • DOI: 10.1007/s10875-016-0357-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A heterozygous dominant-negative mutation in the coiled-coil domain of STAT1 is the cause of autosomal-dominant Mendelian susceptibility to mycobacterial diseases. (2017)
  • Author(s): Ueki M, Yamada M, Ito K, Tozawa Y, Morino S, Horikoshi Y, Takada H, Abdrabou SS, Takezaki S, Kobayashi I, Ariga T.
  • Journal Title: Clin Immunol. Volume: 174 Pages: 24-31
  • DOI: 10.1016/j.clim.2016.11.004
  • Peer Reviewed
• [Journal Article] Activated phosphoinositide 3-kinase δ syndrome presenting with gut-associated T-cell lymphoproliferative disease (2017)
  • Author(s): Teranishi H, Ishimura M, Koga Y, Eguchi K, Sonoda M, Kobayashi T, Shiraishi S, Nakashima K, Ikegami K, Aman M, Yamamoto H, Takada H, Ohga S.
  • Journal Title: Rinsho Ketsueki Volume: 58 Issue: 1 Pages: 20-25
  • DOI: 10.11406/rinketsu.58.20
  • NAID: 130005394596
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis. (2017)
  • Author(s): Yamada T, Kubota T, Yonezawa M, Nishio H, Kanno S, Yano T, Kobayashi D, Egashira N, Takada H, Hara T, Masuda S.
  • Journal Title: Pediatr Infect Dis J. Volume: 36 Issue: 4 Pages: 398-400
  • DOI: 10.1097/inf.0000000000001456
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 原発性免疫不全成人症例診療の問題点 (2017)
  • Author(s): 高田英俊
  • Journal Title: 小児感染免疫 Volume: 29 (2) Pages: 177-182
  • Peer Reviewed
• [Journal Article] 日本小児感染症学会推薦総説. 感染症と原発性免疫不全症 (2017)
  • Author(s): 高田英俊
  • Journal Title: 日本小児科学会雑誌 Volume: 121 (10) Pages: 1654-1661
  • NAID: 40021366025
  • Peer Reviewed
• [Journal Article] 原発性免疫不全症に対する造血幹細胞移植 (2017)
  • Author(s): 高田英俊
  • Journal Title: 血液内科 Volume: 75 (4) Pages: 522-528
  • NAID: 40021366258
  • Peer Reviewed
• [Journal Article] Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion. (2017)
  • Author(s): Ichimiya Y, Kaku N, Sakai Y, Yamashita F, Matsuoka W, Muraoka M, Akamine S, Mizuguchi S, Torio M, Motomura Y, Hirata Y, Ishizaki Y, Sanefuji M, Torisu H, Takada H, Maehara Y, Ohga S.
  • Journal Title: Brain Dev. Volume: - Issue: 7 Pages: 621-624
  • DOI: 10.1016/j.braindev.2017.03.023
  • Peer Reviewed
• [Journal Article] Silent Progression of Coronary Artery Thrombosis in a Pregnant Woman With Anomalous Origin of Left Coronary Artery From the Pulmonary Artery (2017)
  • Author(s): Kenichiro Yamamura, Ichiro Sakamoto, Yuzo Yamasaki, Arisa Fujiwara, Michinobu Nagao, Hidetoshi Takada
  • Journal Title: Circulation Journal Volume: 81 Issue: 8 Pages: 1236-1237
  • DOI: 10.1253/circj.CJ-16-1248
  • NAID: 130005859068
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Resolution of Hydronephrosis in a Patient With Mucopolysaccharidosis Type II With Enzyme Replacement Therapy. (2017)
  • Author(s): Nishiyama K, Imai T, Ohkubo K, Sanefuji M, Takada H.
  • Journal Title: Urology Volume: 101 Pages: 163-165
  • DOI: 10.1016/j.urology.2016.12.010
  • Peer Reviewed
• [Journal Article] An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants. (2017)
  • Author(s): Ochiai M, Kurata H, Inoue H, Tanaka K, Matsushita Y, Fujiyoshi J, Wakata Y, Kato K, Taguchi T, Takada H.
  • Journal Title: Neonatology Volume: 111
  • Peer Reviewed
• [Journal Article] Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants (2016)
  • Author(s): Kagawa R, Fujiki R, Tsumura M, Sakata S, Nishimura S,Itan Y, Kong XF, Kato Z, Ohnishi H, Hirata O, Saito S, Ikeda M,Baghdadi JE, Bousfiha A, Fujiwara K, Oleastro M, Yancoski J,Perez L, Danielian S, Ailal F, Takada H, Hara T, Anne Puel A, Boisson-Dupuis S, Bustamante J, Casanova JL, Ohara O, Okada S, Masao Kobayashi M.
  • Journal Title: J Allergy Clin Immunol. Volume: － Issue: 1 Pages: 232-241
  • DOI: 10.1016/j.jaci.2016.09.035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term safety and efficacy of canakinumab in cryopyrin-associated periodic syndrome: results from an open-label, phase III pivotal study in Japanese patients. (2016)
  • Author(s): Yokota S, Imagawa T, Nishikomori R, Takada H, Abrams K, Lheritier K, Heike T, Hara T.
  • Journal Title: Clin Exp Rheumatol. Volume: -
  • Peer Reviewed
• [Journal Article] A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. (2016)
  • Author(s): 12.Nanishi E, Hoshina T, Takada H, Ishimura M, Nishio H, Uehara T, Mizuno Y, Hasegawa S, Ohga S, Nagao M, Igarashi M, Yajima S, Kusumoto Y, Onishi N, Sasahara Y, Yasumi T, Heike T, Hara T, Kumaki S, et al.;
  • Journal Title: J Infect. Volume: 73 Issue: 4 Pages: 358-368
  • DOI: 10.1016/j.jinf.2016.07.018
  • Peer Reviewed
• [Journal Article] A paediatric case of successful non-myeloablative bone marrow transplantation after azacitidine therapy for non-Down syndrome acute megakaryoblastic leukaemia with monosomy 7. (2016)
  • Author(s): Koga Y, Oba U, Kato W, Ono H, Nakashima K, Takada H.
  • Journal Title: Pediatr Transplant. Volume: 20 Issue: 6 Pages: 868-870
  • DOI: 10.1111/petr.12739
  • Peer Reviewed
• [Journal Article] Is Metastatic Rhabdomyosarcoma an Indication for Cardioverter Defibrillator Implantation? (2016)
  • Author(s): Tocan V, Koga Y, Ono H, Nakashima K, Terashi E, Morihana E, Yamamura K, Sakamoto T, Takada H.
  • Journal Title: Pediatr Blood Cancer Volume: 63 Issue: 8 Pages: 1501-1502
  • DOI: 10.1002/pbc.26004
  • Peer Reviewed
• [Journal Article] Immunoregulatory function of neonatal nucleated red blood cells in humans. (2016)
  • Author(s): Cui L, Takada H, Takimoto T, Fujiyoshi J, Ishimura M, Hara T.
  • Journal Title: Immunobiology. Volume: 221(8) Issue: 8 Pages: 853-61
  • DOI: 10.1016/j.imbio.2016.04.004
  • Peer Reviewed
• [Journal Article] Insufficient immune reconstitution after allogeneic cord blood transplantation without chemotherapy conditioning in patients with SCID caused by CD3delta deficiency. (2016)
  • Author(s): Takada H, Ishimura M, Hara T.
  • Journal Title: Bone Marrow Transplant Volume: 未 Issue: 8 Pages: 1131-1133
  • DOI: 10.1038/bmt.2016.64
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. (2016)
  • Author(s): Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.
  • Journal Title: Sci Rep Volume: 未 Issue: 1 Pages: 22991-22991
  • DOI: 10.1038/srep22991
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of Death Due to Infectious Diseases in Patients Hospitalized in the Pediatric Ward of a Single Japanese Tertiary Medical Facility. (2016)
  • Author(s): Toda N, Hoshina T, Koga Y, Ochiai M, Kaku N, Yamamura K, Torisu H, Ihara K, Takada H, Maehara Y, Hara T.
  • Journal Title: Jpn J Infect Dis. Volume: 69 Pages: 464-470
  • NAID: 130005284208
  • Peer Reviewed
• [Journal Article] Activation of Nod1 Signaling Induces Fetal Growth Restriction and Death through Fetal and Maternal Vasculopathy. (2016)
  • Author(s): Inoue H, Nishio H, Takada H, Sakai Y, Nanishi E, Ochiai M, Onimaru M, Chen SJ, Matsui T, Hara T.
  • Journal Title: J Immunol Volume: 196 Issue: 6 Pages: 2779-87
  • DOI: 10.4049/jimmunol.1500295
  • Peer Reviewed / Open Access
• [Journal Article] Invasive Bacterial Infection in Patients with Interleukin-1 Receptor-associated Kinase 4 Deficiency: Case Report. (2016)
  • Author(s): Takada H, Ishimura M, Takimoto T, Kohagura T, Yoshikawa H, Imaizumi M, Shichijyou K, Shimabukuro Y, Kise T, Hyakuna N, Ohara O, Nonoyama S, Hara T.
  • Journal Title: Medicine (Baltimore) Volume: 95(4) Issue: 4 Pages: e2437-e2437
  • DOI: 10.1097/md.0000000000002437
  • NAID: 120006955924
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report. (2016)
  • Author(s): T. Yanagi, T. Mizuochi, Y. Takaki, K. Eda, K. Mitsuyama, M. Ishimura, H. Takada, D. S. Shouval, A. E. Griffith, S. B. Snapper, Y. Yamashita, and K. Yamamoto
  • Journal Title: BMC Gastroenterology Volume: 16 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s12876-016-0424-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of the death due to infectious diseases in the patients hospitalized in the pediatric ward of a single Japanese tertiary medical facility. (2016)
  • Author(s): Toda N, Hoshina T, Koga Y, Ochiai M, Kaku N, Yamamura K, Torisu H, Ihara K, Takada H, Maehara Y, Hara T.
  • Journal Title: Jpn J Infect Dis Volume: 未
  • NAID: 130005284208
  • Peer Reviewed / Open Access
• [Journal Article] BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector. (2016)
  • Author(s): Yamamoto H, Ishimura M, Ochiai M, Takada H, Kusuhara K, Nakatsu Y, Tsuzuki T, Mitani K, Hara T.
  • Journal Title: Gene Ther Volume: 23 Issue: 2 Pages: 205-13
  • DOI: 10.1038/gt.2015.91
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of eculizumab in childhood atypical hemolytic uremic syndrome in Japan. (2016)
  • Author(s): Ito N, Hataya H, Saida K, Amano Y, Hidaka Y, Motoyoshi Y, Ohta T, Yoshida Y, Terano C, Iwasa T, Kubota W, Takada H, Hara T, Fujimura Y, Ito S.
  • Journal Title: Clin Exp Nephrol Volume: 20 Issue: 2 Pages: 265-72
  • DOI: 10.1007/s10157-015-1142-y
  • Peer Reviewed / Open Access
• [Journal Article] Idiopathic disseminated bacillus Calmette-Guerin infection in three infants. (2015)
  • Author(s): Kido J, Mizukami T, Ohara O, Takada H, Yanai M.
  • Journal Title: Pediatr Int Volume: 57 Issue: 4 Pages: 750-3
  • DOI: 10.1111/ped.12623
  • Peer Reviewed / Open Access
• [Journal Article] Wiskott-Aldrich syndrome in a girl caused by heterozygous WASP mutation and extremely skewed X-chromosome inactivation: a novel association with maternal uniparental isodisomy 6 (2015)
  • Author(s): Takimoto T, Takada H, Ishimura M, Kirino M, Hata K, Ohara O, Morio T, Hara T
  • Journal Title: Neonatology Volume: 107 Issue: 3 Pages: 185-190
  • DOI: 10.1159/000370059
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mutations in Bruton's tyrosine kinase impair IgA responses. (2015)
  • Author(s): Mitsuiki N, Yang X, S, Bartol SJ, Grosserichter-Wagener C, Kosaka Y, Takada H, Imai K, Kanegane H, Mizutani S, van der Burg M, van Zelm MC, Ohara O, Morio T.
  • Journal Title: Int J Hematol. Volume: 101(3) Issue: 3 Pages: 305-13
  • DOI: 10.1007/s12185-015-1732-1
  • Peer Reviewed / Open Access
• [Journal Article] Pilocytic astrocytoma at the medulla oblongata dorsal surface presenting as intractable hiccups. (2015)
  • Author(s): Tanaka Y, Koga Y, Takada H.
  • Journal Title: Pediatr Neurol Volume: 52 Issue: 2 Pages: 254-5
  • DOI: 10.1016/j.pediatrneurol.2014.10.029
  • Peer Reviewed / Open Access
• [Presentation] Insufficient immune reconstitution after allogeneic cord blood transplantation without chemotherapy conditioning in patients with severe combined immunodeficiency caused by CD3δ deficiency (2017)
  • Author(s): Takada H, Ishimura M, Ohga S, Hara T
  • Organizer: 13th Asian Society for Pediatric Research
  • Int'l Joint Research
• [Presentation] Insufficient immune reconstitution after allogeneic cord blood transplantation without chemotherapy conditioning in patients with severe combined immunodeficiency caused by CD3δ deficiency (2017)
  • Author(s): Takada H, Ishimura M, Toshiro Hara
  • Organizer: The 8th Japanese Society of Hematology International Symposium
  • Int'l Joint Research
• [Presentation] BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector and CRISPR/Cas9 system. (2017)
  • Author(s): Yamamoto H, Takada H, Ishimura M, Ochiai M, Hara T, Ohga S.
  • Organizer: The 8th Japanese Society of Hematology International Symposium
  • Int'l Joint Research
• [Presentation] Defects in innate immunity and acquired immunity in humans and immunoglobulin therapy. (2017)
  • Author(s): Takada H
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology.
  • Invited
• [Presentation] 免疫不全症患者への予防接種. (2017)
  • Author(s): 高田英俊
  • Organizer: 第21回日本ワクチン学会
  • Invited
• [Presentation] Primary immunodeficiency diseases associated with hematopoietic disorders: border between immunodeficiency and bone marrow failure Curative treatment for primary immunodeficiency diseases: Hematopoietic stem cell transplantation and gene therapy (2016)
  • Author(s): Takada H
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-15
  • Invited
• [Presentation] 原発性免疫不全症成人症例診療の問題点 (2016)
  • Author(s): 高田英俊
  • Organizer: 第48回日本小児感染症学会
  • Place of Presentation: 岡山
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] Insufficient immune reconstitution after allogeneic cord blood transplantation without chemotherapy conditioning in patients with severe combined immunodeficiency caused by CD3d deficiency (2016)
  • Author(s): Takada H, Ishimura M, Hara T
  • Organizer: 17th Biennial Meeting of the European Society for Immunodeficiencies
  • Place of Presentation: Barcelona
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Immunoregulatory function of neonatal nucleated red blood cells in humans (2015)
  • Author(s): Lili Cui, Hidetoshi Takada, Tomohito Takimoto, Junko Fujiyoshi, Masataka Ishimura, Toshiro Hara
  • Organizer: 第44回日本免疫学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-18
• [Presentation] 有核赤血球による自然免疫制御 (2015)
  • Author(s): 高田英俊、崔 麗莉、瀧本智仁、石村匡崇、藤吉潤子、原 寿郎
  • Organizer: 第43回日本臨床免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-22
• [Presentation] Symposium: Primary Immunodeficiency Diseases: Basic and clinical advances: Gene therapy for PID: A novel approach. (2015)
  • Author(s): Takada H
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: Osaka
  • Year and Date: 2015-08-15
  • Int'l Joint Research
• [Presentation] 二世代および三世代にわたって見られた地中海熱 (2015)
  • Author(s): 高田英俊、石村匡崇、瀧本智仁、原 寿郎
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-17
• [Presentation] IRAK4欠損症の2例 (2015)
  • Author(s): 古波蔵都秋、笠 麻裕、屋良朝太郎、石橋孝勇、宮城 元、新垣律子、井上円佳、大城登喜子、島袋美起子、徳永孝史、桃原由二、新垣洋平、平山良道、渡久地鈴香、伊波 徹、屋良朝雄、高田英俊
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-17
• [Presentation] BCG接種1年後に左上腕骨骨髄炎を発症した1歳男児例 (2015)
  • Author(s): 兼安 秀信, 脇 和之, 富永 康弘, 村松 慶一, 大楠 清文, 高田 英俊, 長谷川 俊史, 大賀 正一
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-17
• [Book] 原発性免疫不全症候群診断の手引き (2017)
  • Author(s): 高田英俊
  • Total Pages: 139
  • Publisher: 診断と治療社
• [Book] 小児血液・腫瘍学 (2015)
  • Author(s): 高田英俊
  • Total Pages: 584
  • Publisher: 診断と治療社