| Project/Area Number |
15K09658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
細矢 光亮 福島県立医科大学, 医学部, 教授 (80192318)
錫谷 達夫 福島県立医科大学, 医学部, 教授 (40196895)
橋本 優子 福島県立医科大学, 医学部, 教授 (60305357)
川崎 幸彦 福島県立医科大学, 医学部, 准教授 (00305369)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | RSV / ワクチン / 中和抗体価 / 臨床分離株 / マウス / 遺伝子型 / マウスモデル |
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| Outline of Final Research Achievements |
Respiratory syncytial virus (RSV) infection is a major disease burden worldwide and vaccine development is desired. In this study, basic research leading to "pregnant women vaccine", which is the closest to practical application, was carried out by mice infection experiments using RSV clinical isolates and measurment of anti-RSV neutralizing antibody titers in adult sera. From the results of the study, it was suggested that choice of antigen recognition site that can lead to neutralizing antibodies in subgroups A and B at the time of vaccine preparation and also capable of coping with genotype change is important.
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