The study of pathophysiology and a role of group 2 innate lymphoid cells in virus-induced bronchial asthma
| Project/Area Number |
15K09665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 泰秀 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
山田 佳之 群馬県衛生環境研究所, 研究企画係, 研究員 (80309252)
望月 博之 東海大学, 医学部, 教授 (50270856)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ウイルス感染 / 気管支喘息 / 好酸球 / サイトカイン / マウス / グループ2自然リンパ球 |
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| Outline of Final Research Achievements |
To investigate the pathogenesis of acute exacerbations of asthma induced by viral infection, we examined bronchial resistance, peripheral blood and bronchial alveolar fluid (BALF) cells analyses and 23 types of cytokines/chemokines using an experimental asthma model mice infected with respiratory syncytial virus (RSV). The levels of BALF and tissue eosinophils showed significant increase in ovalbumin (OVA) and OVA/RSV groups compared with controls. MIP-1α in BALF was significantly increased in OVA/RSV groups compared with RSV groups, OVA groups, and control groups. Serum IL-5 in OVA groups and serum IL-17 in OVA/RSV groups were also higher than in controls. These findings suggest that eosinophilic inflammation via MIP-1α, IL-5, and IL-17 may play an important role in acute exacerbations of asthma model induced by RSV.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] IP-10 Is Elevated in Virus-Induced Acute Exacerbations in Childhood Asthma.2016
Author(s)
Suzuki K, Kato M, Matsuda S, Nukaga M, Enseki M, Tabata H, Hirai K, Yamada Y, Maruyama K, Hayashi Y, Mochizuki H.
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Journal Title
Tokai J Exp Clin Med.
Volume: 41
Pages: 210-217
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] 小児の急性喘鳴および喘息発作時におけるウイルス検索とサイトカイン産生プロファイルの相違.2016
Author(s)
加藤政彦, 松田晋一, 鈴木一雄, 額賀真理子, 煙石真弓, 田端秀之, 平井康太, 山田佳之, 丸山健一, 望月博之.
Organizer
第49回日本小児呼吸器学会.
Place of Presentation
富山国際会議場, 富山市, 富山県.
Related Report
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