| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
This study aimed to analyze the dynamics of allergen-specific type 2 helper T cells (Th2), regulatory T cells (Treg) and basophils in oral immunotherapy (OIT) participants to improve the treatment of food allergies.
After 4 months, patients receiving OIT using hypoallergenic peptide milk exhibited a marked decline in the number of IL-4 producing milk-specific T cells, implying OIT exerts its effects through the inhibition of Th2. In OIT combined with anti-IgE antibody therapy, the basophil activation test (BAT) was completely depressed by anti-IgE therapy only in a case where the succeeding OIT was effective. It might suggest that BAT is useful for determining the optimal dose of anti-IgE antibody and predicting its efficacy.
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