Roll of innate immune system in vasculitis of Kawasaki disease

Research Project

Project/Area Number	15K09681
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pediatrics
Research Institution	The University of Tokyo
Principal Investigator	HIRATA Yoichiro 東京大学, 医学部附属病院, 講師 (40447397)
Co-Investigator(Kenkyū-buntansha)	犬塚亮東京大学, 医学部附属病院, 講師 (00597560) 東邦康智東京大学, 医学部附属病院, 助教 (10586481)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	川崎病 / 血管炎 / 冠動脈 / 自然免疫 / TLR / NLRP3 / HMGB1
Outline of Final Research Achievements	We performed in vivo investigation about the role of innate immune system in vasculitis of Kawasaki disease with CAWS-treated mouse model. Unfortunately, we found no statistically significant differences between the severity score of vasculitis wild type mice and TLR- knockout mice. We decided that the role of TLR system in Kawasaki disease vasculitis in relatively modest. We are going to continue the investigation about Kawasaki disease vasculitis through the immune system of thymus and T-cells.