| Project/Area Number |
15K09686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高崎 一朗 富山大学, 大学院理工学研究部(工学), 准教授 (00397176)
山本 誠士 富山大学, 大学院医学薬学研究部(医学), 助教 (10456361)
伊吹 圭二郎 富山大学, 附属病院, 医員 (20566096)
市田 蕗子 富山大学, 事務局, 学長補佐 (30223100)
小澤 綾佳 富山大学, 附属病院, 診療助手 (40596540)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 川崎病 / 血管内皮微小粒子 / 血管炎 / 血管内皮細胞 / 微少粒子 |
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| Outline of Final Research Achievements |
EMPs could serve as a sensitive marker for characterizing the severity of endothelial damage and vasculitis in acute KD. Moreover, these specific miRs, hsa-miR-145-5p and hsa-miR-320a, may participate in modulation of inflammatory cytokine expression levels, and may contribute to pathogenesis of vasculitis in acute KD. Our novel findings might offer a new clinical approach for the treatment of KD. Further efforts are needed to develop the highly efficient molecular targeting therapies for KD.
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