Establishment of new diagnostic biomarker for childhood IgA nephropathy

• Project/Area Number: 15K09694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: Shima Yuko 和歌山県立医科大学, 医学部, 講師 (60433364)
• Co-Investigator(Kenkyū-buntansha): 吉川 徳茂 和歌山県立医科大学, 医学部, 臨床研究センター長 (10158412) ; 中西 浩一 琉球大学, 医学(系)研究科(研究院), 教授 (50336880)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児ＩｇＡ腎症 / 尿バイオマーカー / 腎生検 / 腎生検組織

Outline of Final Research Achievements

IgA nephropathy is the most common form of chronic glomerulonephritis and the main cause of end-stage renal disease. Diagnosis of IgA nephropathy require invasive kidney biopsies.So we examined the usefullness of more non-invasive urine biomarkers for the diagnosis of IgA nephropathy and its severity.
We compared the expressions of mRNA (L-FABP, Megalin, Thy1, Cubilin, KIM-1, IL-18) of urine between in the patients with IgA nephropathy and other chronic kidney diseases.
The expressions of L-FABP1, Megalin, Thy1, Cubilin is significantly lower in IgA nephropathy than the other. And the expression of KIM-1 is significantly correlated with proteinuria and hematuria in IgA nephropathy. The cases with crescents showed significantly higher level of IL-8. The expression of Gd-IgA1 was found in tha patients with other glomerulonephritis.

Academic Significance and Societal Importance of the Research Achievements

IgA腎症は最多の慢性糸球体腎炎であり、腎不全の原因となるため早期に診断し治療が必要であるが、これまで侵襲的な腎生検による診断が必要であるため、一部の医療機関でしか施行できず、入院を必要とする侵襲的検査であり、医療的介入の遅れにつながると考えられた。
今回行った非侵襲的検査である尿検査でのバイオマーカーの測定により、IgA腎症の病勢の把握が可能となる可能性があり、これまで病勢の把握のために反復腎生検の施行を考慮しなければならなかった状態が回避できると思われる。
ただ今回の研究では、様々なバイオマーカーを測定したがIgA腎症特異的マーカーを見出すことが出来なかった為更なる研究の積み重ねが必要である。

Research Products

• [Journal Article] Clinical spectrum of male patients with OFD1 mutations. (2019)
  • Author(s): Sakakibara N, Morisada N, Nozu K, Nagatani K, Ohta T, Shimizu J, Wada T, Shima Y, Yamamura T, Minamikawa S, Fujimura J, Horinouchi T, Nagano C, Shono A, Ye MJ, Nozu Y, Nakanishi K, Iijima K.
  • Journal Title: J Hum Genet. Volume: 64 Issue: 1 Pages: 3-9
  • DOI: 10.1038/s10038-018-0532-x
  • NAID: 120006888530
  • Peer Reviewed
• [Journal Article] Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study). (2019)
  • Author(s): Shima Y, Nakanishi K, Sako M, Saito-Oba M, Hamasaki Y, Hataya H, Honda M, Kamei K, Ishikura K, Ito S, Kaito H, Tanaka R, Nozu K, Nakamura H, Ohashi Y, Iijima K, Yoshikawa N; Japanese Study Group of Kidney Disease in Children (JSKDC).
  • Journal Title: Pediatr Nephrol. Volume: 34 Issue: 5 Pages: 837-846
  • DOI: 10.1007/s00467-018-4099-8
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics in Patients With Gitelman Syndrome. (2018)
  • Author(s): Fujimura J, Nozu K, Yamamura T, Minamikawa S, Nakanishi K, Horinouchi T, Nagano C, Sakakibara N, Nakanishi K, Shima Y, Miyako K, Nozu Y, Morisada N, Nagase H, Ninchoji T, Kaito H, Iijima K.
  • Journal Title: Kidney Int Rep. Volume: ４ Issue: 1 Pages: 119-125
  • DOI: 10.1016/j.ekir.2018.09.015
  • NAID: 120006847258
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological characteristics and renal outcomes of childhood-onset lupus nephritis with acute kidney injury: A multicenter study. (2018)
  • Author(s): Ishimori S, Kaito H, Shima Y, Kamioka I, Hamahira K, Nozu K, Nakanishi K, Tanaka R, Yoshikawa N, Iijima K.
  • Journal Title: Mod Rheumatol. Volume: 印刷中 Issue: 6 Pages: 970-976
  • DOI: 10.1080/14397595.2018.1532861
  • Peer Reviewed
• [Journal Article] Study protocol: high-dose mizoribine with prednisolone therapy in short-term relapsing steroid-sensitive nephrotic syndrome to prevent frequent relapse (JSKDC05 trial). (2018)
  • Author(s): Hama T, Nakanishi K, Ishikura K, Ito S, Nakamura H, Sako M, Saito-Oba M, Nozu K, Shima Y, Iijima K, Yoshikawa N; Japanese Study Group of Kidney Disease in Children (JSKDC).
  • Journal Title: BMC Nephrol. Volume: 19 Issue: 1 Pages: 223-223
  • DOI: 10.1186/s12882-018-1033-z
  • NAID: 120006523804
  • Peer Reviewed / Open Access
• [Journal Article] Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. (2018)
  • Author(s): Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, Iijima K
  • Journal Title: J Am Soc Nephrol. Volume: 29 Issue: 8 Pages: 2189-2199
  • DOI: 10.1681/asn.2017080859
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT. (2018)
  • Author(s): Shima Y, Nakanishi K, Kaku Y, Ishikura K, Hataya H, Matsuyama T, Honda M, Sako M, Nozu K, Tanaka R, Iijima K, Yoshikawa N; Japanese Pediatric IgA Nephropathy Treatment Study Group.
  • Journal Title: Pediatr Nephrol. Volume: 33 Issue: 11 Pages: 2103-2112
  • DOI: 10.1007/s00467-018-4011-6
  • Peer Reviewed
• [Journal Article] Detection of Splicing Abnormalities and Genotype-Phenotype Correlation in X-linked Alport Syndrome. (2018)
  • Author(s): Horinouchi T, Nozu K, Yamamura T, Minamikawa S, Omori T, Nakanishi K, Fujimura J, Ashida A, Kitamura M, Kawano M, Shimabukuro W, Kitabayashi C, Imafuku A, Tamagaki K, Kamei K, Okamoto K, Fujinaga S, Oka M, Igarashi T, Miyazono A, Sawanobori E, Fujimaru R, Nakanishi K, Shima Y et al
  • Journal Title: J Am Soc Nephrol. Volume: 29 Issue: 8 Pages: 2244-2254
  • DOI: 10.1681/asn.2018030228
  • Peer Reviewed / Open Access
• [Journal Article] Serine Protease Inhibitor Kazal Type I (SPINK1) Mutation: A Risk Factor for Early-onset Chronic Pancreatitis? (2018)
  • Author(s): Hama T, Nakanishi N, Suzuki M, Shima Y, Suzuki H.
  • Journal Title: J Pediatr Gastroenterol Nutr. Volume: 67 Issue: 2
  • DOI: 10.1097/mpg.0000000000002024
  • Peer Reviewed
• [Journal Article] Development of ultra-deep targeted RNA sequencing for analyzing X-chromosome inactivation in female Dent disease (2018)
  • Author(s): Minamikawa S, Nozu K, Nozu Y, Yamamura T, Taniguchi-Ikeda M, Nakanishi K, Fujimura J, Horinouchi T, Shima Y, Nakanishi K, Hattori M, Kanda K, Tanaka R, Morisada N, Nagano C, Sakakibara N, Nagase H, Morioka I, Kaito H, Iijima K.
  • Journal Title: Journal of Human Genetics Volume: 63 Issue: 5 Pages: 589-595
  • DOI: 10.1038/s10038-018-0415-1
  • Peer Reviewed
• [Journal Article] IgA nephropathy with presentation of nephrotic syndrome at onset in children. (2017)
  • Author(s): Shima Y, Nakanishi K, Sato M, Hama T, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Suzuki H, Yoshikawa N.
  • Journal Title: Pediatr Nephrol. Volume: 32(3) Issue: 3 Pages: 457-465
  • DOI: 10.1007/s00467-016-3502-6
  • Peer Reviewed
• [Journal Article] Diagnostic strategy for inherited hypomagnesemia. (2017)
  • Author(s): Horinouchi T, Nozu K, Kamiyoshi N, Kamei K, Togawa H, Shima Y, Urahama Y, Yamamura T, Minamikawa S, Nakanishi K, Fujimura J, Morioka I, Ninchoji T, Kaito H, Nakanishi K, Iijima K.
  • Journal Title: Clin Exp Nephrol. Volume: 印刷中 Issue: 6 Pages: 1003-1010
  • DOI: 10.1007/s10157-017-1396-7
  • Peer Reviewed
• [Journal Article] Oxford Classification of IgA nephropathy 2016-the role of crescentic lesions: an update from the IgA Nephropathy Classification Working Group. (2017)
  • Author(s): Trimarchi H, Barratt J, Cattran DC, Cook HT, Coppo R, Haas M, Liu ZH, Roberts IS, Yuzawa Y, Zhang H, Feehally J; IgAN Classification Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.; Conference Participants..
  • Journal Title: Kidney Int. Volume: 印刷中 Issue: 5 Pages: 1014-1021
  • DOI: 10.1016/j.kint.2017.02.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease (2017)
  • Author(s): Hama Taketsugu、Nakanishi Koichi、Sato Masashi、Mukaiyama Hironobu、Togawa Hiroko、Shima Yuko、Miyajima Masayasu、Nozu Kandai、Nagao Shizuko、Takahashi Hisahide、Sako Mayumi、Iijima Kazumoto、Yoshikawa Norishige、Suzuki Hiroyuki
  • Journal Title: American Journal of Physiology-Renal Physiology Volume: 313 Issue: 6 Pages: F1223-F1231
  • DOI: 10.1152/ajprenal.00697.2016
  • Peer Reviewed
• [Journal Article] Natural History and Genotype?Phenotype Correlation in Female X-Linked Alport Syndrome (2017)
  • Author(s): Yamamura Tomohiko、Nozu Kandai、Fu Xue Jun、Nozu Yoshimi、Ye Ming Juan、Shono Akemi、Yamanouchi Satoko、Minamikawa Shogo、Morisada Naoya、Nakanishi Koichi、Shima Yuko、Yoshikawa Norishige、Ninchoji Takeshi、Morioka Ichiro、Kaito Hiroshi、Iijima Kazumoto
  • Journal Title: Kidney Int Rep. Volume: 2 Issue: 5 Pages: 850-855
  • DOI: 10.1016/j.ekir.2017.04.011
  • NAID: 120006373817
  • Peer Reviewed / Open Access
• [Journal Article] X-linked Alport syndrome associated with a synonymous p.Gly292Gly mutation alters the splicing donor site of the type IV collagen alpha chain 5 gene. (2016)
  • Author(s): Fu XJ, Nozu K, Eguchi A, Nozu Y, Morisada N, Shono A, Taniguchi-Ikeda M, Shima Y, Nakanishi K, Vorechovsky I, Iijima K.
  • Journal Title: Clin Exp Nephrol. Volume: 20(5) Pages: 699-702
  • Peer Reviewed
• [Journal Article] Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter/Gitelman syndrome based on clinical characteristics (2016)
  • Author(s): Matsunoshita N, Nozu K, Shono A, Nozu Y, Fu XJ, Morisada N, Kamiyoshi N, Ohtsubo H, Ninchoji T, Minamikawa S, Yamamura T, Nakanishi K, Yoshikawa N, Shima Y, Kaito H, Iijima K
  • Journal Title: Genetics in Medicine Volume: 18 Issue: 2 Pages: 180-188
  • DOI: 10.1038/gim.2015.56
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long-term outcome of childhood IgA nephropathy with minimal proteinuria. (2015)
  • Author(s): Higa A, Shima Y, Hama T, Sato M, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Nakanishi K, Yoshikawa N.
  • Journal Title: Pediatr Nephrol. Volume: 30(12) Issue: 12 Pages: 2121-7
  • DOI: 10.1007/s00467-015-3176-5
  • Peer Reviewed
• [Journal Article] Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset (2015)
  • Author(s): Hama T, Nakanishi K, Shima Y, Sato M, Mukaiyama H, Togawa H, Hamahira K, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N
  • Journal Title: Pediatr Nephrol Volume: 30 Issue: 3 Pages: 445-450
  • DOI: 10.1007/s00467-014-2946-9
  • Peer Reviewed
• [Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment (2015)
  • Author(s): Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K
  • Journal Title: Kidney Int Volume: 87 Issue: 1 Pages: 225-232
  • DOI: 10.1038/ki.2014.260
  • Peer Reviewed / Open Access
• [Journal Article] Biopsy timing and Oxford classification variables in childhood/adolescent IgA nephropathy. (2015)
  • Author(s): Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N.
  • Journal Title: Pediatric Nephrollogy Volume: 30(2) Issue: 2 Pages: 293-9
  • DOI: 10.1007/s00467-014-2862-z
  • Peer Reviewed
• [Presentation] 小児IgA腎症における蛋白尿再燃因子の検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、鈴木啓之
  • Organizer: 日本小児科学会学術集会
• [Presentation] 小児Silent lupus nephritisに関する臨床病理学的検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、佐藤匡、向山弘展、戸川寛子、貝藤裕史、野津寛大、田中亮二郎、鈴木啓之、飯島一誠、吉川徳茂
  • Organizer: 日本小児腎臓病学会
• [Presentation] 小児IgA腎症における蛋白尿再燃因子の検討 (2018)
  • Author(s): 島友子、中西浩一、浜武継、田中侑、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、吉川徳茂、鈴木啓之
  • Organizer: 日本小児腎不全学会
• [Presentation] Clinicopathological significance in juvenile-onset silent lupus nephritis (2018)
  • Author(s): Yuko Shima, Koichi Nakanishi, Taketsugu Hama, Masashi Sato, Yu Tanaka, Hironobu Mukaiyama, Hiroshi Kaito, Kandai Nozu, Ryojiro Tanaka, Hiroyuki Suzuki, Kazumoto Iijima, Norishige Yoshikawa
  • Organizer: American Society of Neprology
  • Int'l Joint Research
• [Presentation] 1.A case of childhood IgA Nephropathy with glomerular capillary IgA deposition. (2017)
  • Author(s): Yuko Shima, Koichi Nakanishi, Masashi Sato,Taketsugu Hama, Hironobu Mukaiyama, Hiroko Togawa, Hiroyuki Suzuki, Norishige Yoshikawa
  • Organizer: The 15th Japan-Korea-China Pediatric nephrology Seminar
  • Int'l Joint Research
• [Presentation] 2.New combination therapy with prednisolone (PSL), mizoribine and lisinopril for severe childhood IgA Nephropathy (IgAN). (2017)
  • Author(s): Norishige Yoshikawa, Yuko Shima, Masashi Sato, Taketsugu Hama, Hironobu Mukaiyam, Hiroko Togawa, Hiroyuki Suzuki, Hiroshi Kaito, Kandai Nozu, Kazumoto Iijima, Koichi Nakanishi
  • Organizer: 50th anniversary meeting of the European Society for Pediatric Nephrology
  • Int'l Joint Research
• [Presentation] 3.Foctors related to proteinuria relapse in childhood IgA Nephropathy (2017)
  • Author(s): Yuko Shima, Koichi Nakanishi, Masashi Sato, Taketsugu Hama, Yu Tanaka, Hironobu Mukaiyama, Hiroko Togawa, Hiroshi Kaito, Kandai Nozu, Ryojiro Tanaka, Kazumoto Iijima, Hiroyuki Suzuki, Norishige Yoshikawa
  • Organizer: 50th Annual Meeting of the American Society of Nephrology
  • Int'l Joint Research
• [Presentation] 小児IgA腎症における糸球体毛細管系蹄IgA沈着の臨床病理学的検討 (2017)
  • Author(s): 1.島友子、中西浩一、濱武継、佐藤匡、向山弘展、戸川寛子、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、鈴木啓之、吉川徳茂.
  • Organizer: 小児IgA腎症における糸球体毛細管系蹄IgA沈着の臨床病理学的検討
• [Presentation] 小児IgA腎症における糸球体毛細管係蹄IgA沈着の臨床病理学的検討 (2017)
  • Author(s): 小児IgA腎症における糸球体毛細管系蹄IgA沈着の臨床病理学的検討
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] Clinicopathological significance of glomerular capillary IgA deposition in childhood IgA Nephropathy (2017)
  • Author(s): Yuko Shima, Koichi Nakanishi, Masashi Sato, Taketsugu Hama, Hironobu Mukaiyama, Hiroko Togawa, Hiroshi Kaito, Kandai Nozu, Ryojiro Tanaka, Kazumoto Iijima, Hiroyuki Suzuki, Norishige Yoshikawa
  • Organizer: 第51回日本小児腎臓病学会
• [Presentation] 小児全身性エリテマトーデス（SLE）における尿所見が軽微なループス腎炎に関する臨床病理学的検討 (2017)
  • Author(s): 4.島友子、中西浩一、浜武継、田中侑、佐藤匡、向山弘展、戸川寛子、鈴木啓之、吉川徳茂
  • Organizer: 第39回日本小児腎不全学会
• [Presentation] Childhood IgA nephropathy presenting acute nephritic syndrome at onset. (2016)
  • Author(s): Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, Kaito H, Nozu K, Tanaka R, Iijima K, Suzuki H, Yoshikawa N
  • Organizer: 49th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-20
  • Int'l Joint Research
• [Presentation] 小児IgA腎症における糸球体毛細管係蹄IgA沈着の臨床病理学的検討 (2016)
  • Author(s): 島友子、中西浩一、佐藤匡、濱武継、向山弘展、戸川寛子、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、鈴木啓之、吉川徳茂
  • Organizer: 第38回小児腎不全学会
  • Place of Presentation: 岐阜
  • Year and Date: 2016-10-27
• [Presentation] Crescentic IgA Nephropathy (C-IgAN) in children. (2016)
  • Author(s): Shima Y, Nakanishi K, Sato M, Nozu K, Tanaka R, Iijima K, Suzuki H, Yoshikawa N.
  • Organizer: 17th congress of International Pediatric Nephrology Association
  • Place of Presentation: Iguaçu, Brazil
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] 発症時急性腎炎症候群を呈する小児IgA腎症（AGN-IgAN）の検討 (2016)
  • Author(s): 島友子、中西浩一、濱武継、佐藤匡、向山弘展、戸川寛子、貝藤裕史、野津寛大、田中亮二郎、飯島一誠、吉川徳茂
  • Organizer: 第51回小児腎臓病学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-07-07
• [Presentation] 半月体形成性糸状体腎炎（CGN）を呈する小児IgA腎症の検討 (2016)
  • Author(s): 島友子、中西浩一、佐藤匡、向山弘展、濱武継、野津寛大、田中亮二郎、飯島一誠、
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
• [Presentation] Childhood IgA nephropathy with nephrotic syndrome (NS-IgAN) at onset. (2015)
  • Author(s): Shima Y, Nakanishi K, Hama T, Sato M, Togawa H, Mukaiyama H, Kaito H, Nozu K, Tanaka R, Iijima K, Yoshikawa N.
  • Organizer: 48th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] 発症時ネフローゼ症候群を呈する小児IgA腎症（NS-IｇAN）の検討． (2015)
  • Author(s): 島友子，中西浩一，濱武継，佐藤匡，向山弘展，戸川寛子，貝藤裕史，野津寛大，田中亮二郎，飯島一誠，吉川徳茂．
  • Organizer: 日本小児腎臓病学会学術集会第50回記念大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-06-18
• [Presentation] IgA腎症発症関連分子の腎における発現． (2015)
  • Author(s): 佐藤匡，島友子，浜武継，向山弘展，戸川寛子，中西浩一，吉川徳茂
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-05
• [Book] ＩｇＡ腎症の臨床 (2018)
  • Author(s): 編集： 湯村 和子
  • Total Pages: 333
  • Publisher: 東京医学社
  • ISBN: 9784885632976
• [Book] 小児腎臓病学改訂第2版、第2章 尿細管間質性疾患 3.Dent病・Lowe症候群 (2017)
  • Author(s): 日本小児腎臓病学会編
  • Total Pages: 434
  • Publisher: 診断と治療社
• [Book] アルポート症候群診療ガイドライン 2017 Ⅱ.疫学・予後 (2017)
  • Author(s): 2.飯島一誠、柏原直樹、中西浩一、井藤奈央子、楠原仙太郎、朽方豊夢、島友子、仲野敦子、野津寛大、濱田陸、林宏樹、南川将吾、山村智彦
  • Total Pages: 89
  • Publisher: 診断と治療社
• [Book] 今日の小児治療指針 (2015)
  • Author(s): IgA腎症
  • Total Pages: 1006
  • Publisher: 医学書院