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Evaluation of the escape mutant of the hepatitis B virus as a minor strain in mother-to-child transmission

Research Project

Project/Area Number 15K09701
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionToho University

Principal Investigator

KOMATSU Haruki  東邦大学, 医学部, 准教授 (80424711)

Co-Investigator(Kenkyū-buntansha) 舘野 昭彦  東邦大学, 医学部, 教授 (10138993)
Research Collaborator INUI Ayano  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsB型肝炎ウイルス / 母子感染 / ワクチン / HBIG / S抗原 / 変異株 / minor clone / 予防不成功 / 遺伝子変異 / 感染予防 / B型肝炎 / 変異ウイルス
Outline of Final Research Achievements

The frequency of the G145R mutant as a minor as well as major strain was approximately 25% in children who were infected due to immunoprophylaxis failure. HBeAg positivity and high viremia were closely related to the detection of the G145R mutant as a minor population in patients without a history of HB vaccinations, HBIG, or antiviral treatment. Although the G145R mutant as a minor population was detected in pregnant women who were HBeAg-positive and had a high viral load, none of the infants born to the mothers infected with the G145R mutation showed breakthrough infection. Thus, the pre-existence of the G145R mutation as a minor population in mothers does not always cause immunoprophylaixs failure after birth. However, treatment with nucleotide analogues for HBV carrier pregnant women, based on an HBeAg-positive status and the level of HBV DNA, should be encouraged to reduce the risk of breakthrough infection.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 急性肝炎2017

    • Author(s)
      小松 陽樹, 乾 あやの, 梅津 守一郎, 十河 剛, 藤澤 知雄
    • Journal Title

      小児科

      Volume: 58 Pages: 1519-1522

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ウイルス性肝炎2017

    • Author(s)
      小松 陽樹, 乾 あやの, 梅津 守一郎, 十河 剛, 藤澤 知雄
    • Journal Title

      小児内科

      Volume: 49 Pages: 1629-1633

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Evaluation of the G145R Mutant of the Hepatitis B Virus as a Minor Strain in Mother-to-Child Transmission2016

    • Author(s)
      Komatsu H, Inui A, Umetsu S, Tsunoda T, Sogo T, Konishi Y, Fujisawa T.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 11 Pages: e0165674-e0165674

    • DOI

      10.1371/journal.pone.0165674

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] B型肝炎母子感染におけるG145R変異株の検討2016

    • Author(s)
      小松陽樹、乾あやの、藤沢知雄
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      東京ベイ幕張ホール (千葉県、千葉市)
    • Year and Date
      2016-05-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Evaluation of the G145R mutant as a minor form in mother-to-child transmission of hepatitis B virus2016

    • Author(s)
      Haruki Komatsu, Ayano Inui, Shuichiro Umetsu, Kentaro Iwasawa, Tomoyuki Tsunoda, Tsuyoshi Sogo, Tomoo Fujisawa
    • Organizer
      34th European Society for Pediatric Infectious Diseases
    • Place of Presentation
      ブライトン(英国)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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