Disorders of placental villus vascular remodeling induced by human cytomegalovirus infection
| Project/Area Number |
15K09709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Kosugi Isao 浜松医科大学, 医学部, 准教授 (10252173)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サイトメガロウイルス / 母子感染 / 胎盤 / 血管リモデリング / デスミン |
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| Outline of Final Research Achievements |
Human cytomegalovirus (CMV) is the leading viral cause of birth defects by congenital infection. Here we investigated HCMV infection of the placenta during the late phase of the infection. HCMV antigen-positive cells were exclusively found in the villus stroma but very rarely in the trophoblast. Most of HCMV-infected cells in the villus stroma were endothelial cells, pericytes and myofibroblasts. The number of viral antigen-positive cells closely correlated with the amount of viral DNA in the sections, suggesting that villus stromal cells, especially capillary endothelial cells and pericytes, are major sites for HCMV replication. In HCMV-infected villi, the disappearance of endothelial cells correlated with the increase in the number of HCMV-infected myofibroblasts. These data indicate that infectious damages of villus capillary vessels cause the fibrosis and the failure of vascular remodeling, resulting in the disturbances of placental functions and the fetal developmental disorders.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Podoplanin-positive myofibroblasts: a pathological hallmark of pleuroparenchymal fibroelastosis.2018
Author(s)
Enomoto Y, Matsushima S, Meguro S, Kawasaki H, Kosugi I, Fujisawa T, Enomoto N, Inui N, Nakamura Y, Suda T, Iwashita T.
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Journal Title
Histopathology.
Volume: 印刷中
Issue: 7
Pages: 1209-1215
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines.2017
Author(s)
Tani S, Takano R, Tamura S, Oishi S, Iwaizumi M, Hamaya Y, Takagaki K, Nagata T, Seto S, Horii T, Kosugi I, Iwashita T, Osawa S, Furuta T, Miyajima H, Sugimoto K.
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Journal Title
Inflamm Bowel Dis.
Volume: 23
Issue: 5
Pages: 728-738
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenotypic characterization of perivascular myoid cell neoplasms, using myosin 1B, a newly identified human pericyte marker2017
Author(s)
Shiori Meguro, Taisuke Akamatsu, Sayomi Matsushima, Isao Kosugi, Hideya Kawasaki, Yoshifumi Arai, Satoshi Baba, Takashi Tsuchida, Yoji Shido, Takafumi Suda, Toshihide Iwashita
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Journal Title
Human Pathology
Volume: 62
Pages: 187-198
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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