The Influences of maternal separation on neural circuit formation during brain development equivalent to preterm infants in human
| Project/Area Number |
15K09715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 辰吾 香川大学, 医学部, 講師 (50451430)
三木 崇範 香川大学, 医学部, 教授 (30274294)
割田 克彦 鳥取大学, 農学部, 准教授 (40452669)
日下 隆 香川大学, 医学部, 教授 (50274288)
金西 賢治 香川大学, 医学部附属病院, 准教授 (10263906)
久保 裕之 香川大学, 医学部, 協力研究員 (30564116)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 母子分離 / 扁桃体 / 内側前頭前皮質 / 興奮/抑制バランス / 攻撃性 / 社会性 / 社会行動 / 社会的認知能力 / 環境エンリッチメント / 攻撃行動 / 脳由来神経栄養因子 / 海馬 / スパイン |
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| Outline of Final Research Achievements |
In this study, we analyzed the influences of maternal separation (MS) during brain development equivalent to preterm infants in human using rat model. Our results showed that MS during brain development increased aggressive behavior and reduced the behavior related to social recognition after maturation. In addition, we found that reduction of various factors (VGAT, Neuroligin-2) related to inhibitory synapse in the amygdala and the medial prefrontal cortex of mature rat exposed to MS. Excitatory/inhibitory imbalance disrupts normal function in these regions, which leads to cause excessive aggression and abnormality of sociability. Our study also revealed these influences of MS are not irreversible, but rather can be recovered depending on nurturing environment after MS.
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Report
(4 results)
Research Products
(8 results)
