Hypothermia attenuate brain damage by coordinating the function of glia
Project/Area Number |
15K09718
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Embryonic/Neonatal medicine
|
Research Institution | Aichi Medical University |
Principal Investigator |
Kakita Hiroki 愛知医科大学, 医学部, 講師 (40528949)
|
Co-Investigator(Kenkyū-buntansha) |
浅井 清文 名古屋市立大学, 大学院医学研究科, 教授 (70212462)
青山 峰芳 名古屋市立大学, 大学院薬学研究科, 教授 (70363918)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 新生児低酸素性虚血性脳症 / グリア / 低体温療法 / 一酸化窒素 / エリスロポエチン / サイトカイン / 低酸素性虚血性脳症 / 脳低温療法 / アストロサイト / ミクログリア |
Outline of Final Research Achievements |
Hypothermia has been reported to be only effective therapy for neonatal hypoxic ischemic encephalopathy (HIE) . We performed the examination of microenviroment improvement of glial function control with hypothermia. We found hypothermia (32-34℃) decreased the expression of iNOS and inflammatory cytokine in cultured glia under hypoxic condition. Furthermore, erythropoietin having neuroprotective effect made clear that overexpression lasted by a low temperature state. We found that these protein expression adjustment by hypothermia decreased brain damage. This study might contribute to the development of an etiology of HIE which is still a poor prognosis and the cure.
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Report
(4 results)
Research Products
(8 results)