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Analysis of the role of HIF in early termination of nephrogenesis due to prematurity and development of treatment.

Research Project

Project/Area Number 15K09726
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKeio University

Principal Investigator

Hida Mariko  慶應義塾大学, 医学部(信濃町), 共同研究員 (20276306)

Co-Investigator(Kenkyū-buntansha) 粟津 緑  慶應義塾大学, 医学部(信濃町), 講師 (20129315)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糸球体減少 / 早産児 / 低酸素環境 / oligmeganephronia / ネフロン形成 / 早産動物モデル / 腎低形成 / 糸球体数減少 / HIF
Outline of Final Research Achievements

We have been analyzing the mechanism of early termination of nephrogenesis in preterm infants. Since a neonate is exposed to higher level of oxygen than in utero, we had hypothesized that the change in expression and activity of hypoxia inducible factor (HIF) would influence on maintenance of nephron progenitor cells, vasculisation, and nephrogenesis. We planned to create preterm model mice and to raise them under hypoxic condition. We had examined the expression and activity of HIF in those model mice. Unfortunately to create preterm mice had been quite difficult. We have succeeded to create one-day-preterm mice, which pathological study suggested that nephrogenesis may terminate earlier than term mice, but we could not raise enough number of model mice for examination. To raise mice under hypoxic condition was also quite difficult. Since they were quite sick under hypoxic condition, we could not make enough assessment. We need to analyze in vitro with organ culture specimens.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (43 results)

All 2017 2016 2015

All Journal Article (13 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (30 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results)

  • [Journal Article] BMP7 dose-dependently stimulates proliferation and cadherin-11 expression via ERK and p38 in a murine metanephric mesenchymal cell line2017

    • Author(s)
      Awazu M, Nagata M, Hida M
    • Journal Title

      Physiol Rep

      Volume: 5 Issue: 16 Pages: e13378-e13378

    • DOI

      10.14814/phy2.13378

    • NAID

      120007134827

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polycythemia, capillary rarefaction, and focal glomerulosclerosis in two adolescents born extremely low birth weight and premature2017

    • Author(s)
      Nariaki Asada, Takanori Tsukahara, Megumi Furuhata, Daisuke Matsuoka, Shunsuke Noda, Kuniaki Naganuma, Akinori Hashiguchi, Midori Awazu
    • Journal Title

      Pediatric Nephrology

      Volume: 印刷中 Issue: 7 Pages: 13-17

    • DOI

      10.1007/s00467-017-3654-z

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tubular dysfunction mimicking Dent's disease in 2 infants born with extremely low birth weight.2017

    • Author(s)
      Awazu M, Arai M, Ohashi S, Takahashi H, Sekine T, Ikeda K.
    • Journal Title

      Case Report in Nephrology and Dialysis

      Volume: 7 Issue: 1 Pages: 13-17

    • DOI

      10.1159/000455828

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient Fanconi syndrome in two preterm infants with hydronephrosis and urinary tract infection2017

    • Author(s)
      Tominaga T, Sato T, Ichihashi Y, Amano N, Kobayashi Y, Awazu M
    • Journal Title

      CEN Case Rep

      Volume: 6 Pages: 88-90

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎臓病へのDOHaDの影響 尿細管・間質、血管2017

    • Author(s)
      粟津緑
    • Journal Title

      小児内科

      Volume: 49 Pages: 493-496

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ネフロン数2017

    • Author(s)
      粟津緑
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 5 Pages: 356-360

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 母体低栄養は片側尿管結紮による腎障害を増悪する ~ラットモデルを用いた検討~2017

    • Author(s)
      飛彈麻里子、阿部時也、橋口明典、粟津緑
    • Journal Title

      発達腎学会誌

      Volume: 25 Pages: 30-33

    • NAID

      120006510782

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 嚢胞性腎疾患・遺伝性腎疾患2017

    • Author(s)
      浅田礼光、粟津緑
    • Journal Title

      小児外科

      Volume: 49 Pages: 903-906

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Nephrogenesisに影響する因子2017

    • Author(s)
      粟津緑
    • Journal Title

      日腎誌

      Volume: 59 Pages: 1244-1246

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 母体低栄養は片側尿管結紮による腎障害を増悪する ~ラットモデルを用いた検討~2017

    • Author(s)
      飛彈麻里子、阿部 時也、橋口 明典、粟津 緑
    • Journal Title

      発達腎研究会誌

      Volume: 印刷中

    • NAID

      120006510782

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 正常後腎発生および母体低栄養ラット後腎の尿管芽分岐、ネフロン数減少におけるDNAメチル化の役割2016

    • Author(s)
      粟津緑、飛彈麻里子
    • Journal Title

      発達腎研究会誌

      Volume: 24 Pages: 9-12

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] White-Coat and Reverse White-Coat Effects Correlate with 24-h Pulse Pressure and Systolic Blood Pressure Variability in Children and Young Adults.2016

    • Author(s)
      Fujita H, Matsuoka S, Awazu M.
    • Journal Title

      Pediatr Cardiol.

      Volume: 37 Issue: 2 Pages: 345-352

    • DOI

      10.1007/s00246-015-1283-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 母体低栄養によるラット後腎の全般的および遺伝子特異的低メチル化2015

    • Author(s)
      粟津緑、飛彈麻里子
    • Journal Title

      発達腎研究会誌

      Volume: 23 Pages: 8-10

    • Related Report
      2015 Research-status Report
  • [Presentation] Cadherin-11 is induced by BMP7 and stimulates cap mesenchyme formation2017

    • Author(s)
      Awazu, Nagata M, Hida M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA hydroxymethylation is altered by maternal nutrient restriction in rat kidney2017

    • Author(s)
      Hida, Oda M, Awazu M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polycythemia in subjects born with a history of preterm birth and extremely low birth weight2017

    • Author(s)
      Asada N, Matsuzaki Y, Awazu M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of growth hormone therapy on renal function in children born small for gestational age2017

    • Author(s)
      Matsumura K, Shibata H, Ishii T, Hasegawa T, Awazu M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A girl with a mutation of the ciliary gene CC2D2A presenting with FSGS and nephronophthisis2017

    • Author(s)
      Matsumura K, Asada N, Hashiguchi A, Kosaki K, Awazu M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient hypertension in a preterm infant after the administration of indomethacin for patent ductus arteriosus2017

    • Author(s)
      Tominaga T, Omori S, Awazu M
    • Organizer
      Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polycythemia and peritubular capillary rarefaction in subjects with a history of preterm and extremely low birth weight2017

    • Author(s)
      Asada N, Matsumura, K., Tsukahara T, Matsuoka D, Furuhata M, Noda S, Naganuma K, Hashiguchi A, Awazu M
    • Organizer
      The 15th Japan-Korea-China Pediatric Nephrology Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nephrogenesisに影響する因子2017

    • Author(s)
      粟津緑
    • Organizer
      第39回腎臓セミナー・Nexus Japan
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 巣状糸球体硬化症と多血症を合併した早産・超低出生体重児の2例2017

    • Author(s)
      塚原 孝典、 松岡 大輔, 日高 義彦, 中沢 洋三, 野田 俊輔, 浅田 礼光, 粟津 緑, 長沼 邦明, 森 哲夫
    • Organizer
      第120回日本小児科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超低出生体重で出生した児における多血症の検討2017

    • Author(s)
      浅田礼光、松村和哉、松崎陽平、池田一成、粟津緑
    • Organizer
      第120回日本小児科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生後早期尿中L型脂肪酸結合蛋白L-FABP高値は新生児仮死の神経学的予後不良を示唆する2017

    • Author(s)
      飛彈麻里子、古谷智子、松井美優、内田陽子、城裕之
    • Organizer
      第120回日本小児科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ERK-MAPキナーゼ経路を治療標的とした糖尿病治療の可能性2017

    • Author(s)
      尾崎惠一、粟津緑、谷村進、河野通明
    • Organizer
      第90回日本内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドヘリン11はBMP7により誘導されcap mesenchyme形成を促進する2017

    • Author(s)
      粟津緑、長田道夫、飛彈麻里子
    • Organizer
      第60回日本腎臓学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドヘリン11はBMP7により誘導されcap mesenchyme形成を促進する2017

    • Author(s)
      粟津緑、長田道夫、飛彈麻里子
    • Organizer
      第52回日本小児腎臓病学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重症新生児仮死児における急性期尿細管機能障害と神経学的予後との関連2017

    • Author(s)
      飛彈麻里子
    • Organizer
      第52回日本小児腎臓病学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] olycythemia in subjects born with a history of preterm birth and extremely low birth weight2017

    • Author(s)
      浅田礼光、松村和哉、松崎陽平、池田一成、粟津緑
    • Organizer
      第52回日本小児腎臓病学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] SGA性低身長症児に対する成長ホルモン療法の腎機能への影響2017

    • Author(s)
      松村和哉、 柴田 浩憲, 石井 智弘, 長谷川 奉延、粟津緑
    • Organizer
      第52回日本小児腎臓病学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 短腸症候群による低栄養、成長障害の改善に伴いGFR低下の増悪を認めた超低出生体重児の1例2017

    • Author(s)
      大森さゆ、 富田 紘史, 薄井 摩稚子、粟津緑
    • Organizer
      第52回日本小児腎臓病学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 巣状糸球体硬化症と多血症を合併し、尿細管周囲毛細血管の菲薄化を認めた早産・低出生体重児の2例2017

    • Author(s)
      野田俊輔、塚原孝典、松岡大輔、日高義彦、粟津緑
    • Organizer
      第26回発達腎研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Caspase-3 Mediates Inhibition of Ureteric Branching and Nephrogenesis by Maternal Nutrient Restriction in Mice2016

    • Author(s)
      Midori Awazu,Yoshifumi Yamaguchi, Masayuki Miura, Mariko Hida.
    • Organizer
      Kidney Week 2016 (American Society of Nephrology Annual Meeting)
    • Place of Presentation
      米国イリノイ州シカゴ市マコーミックコンベンションセンター
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Aggravated Unilateral Ureteral Obstruction-Induced Renal Injury in Rat Offspring with Maternal Nutrient Restriction Is via Decreased Renal Nitric Oxide Production2016

    • Author(s)
      Mariko Hida,Tokiya Abe,Akinori Hashiguchi, Midori Awazu
    • Organizer
      Kidney Week 2016 (American Society of Nephrology Annual Meeting)
    • Place of Presentation
      米国イリノイ州シカゴ市マコーミックコンベンションセンター
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 母体低栄養ラットにおける片側尿管結紮による腎障害の増悪機序 -腎NO産生の低下-2016

    • Author(s)
      飛彈麻里子、阿部 時也、橋口 明典、粟津 緑
    • Organizer
      第51回日本小児腎臓病学会学術集会
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 母体低栄養による尿管芽分岐抑制・ネフロン数減少におけるcaspase-3の役割2016

    • Author(s)
      粟津緑、山口良文、三浦正幸、飛彈麻里子
    • Organizer
      第51回日本小児腎臓病学会学術集会
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 葉酸は母体低栄養・メチル酸ドナー欠乏による尿管芽分岐・ネフロン数減少を改善する2016

    • Author(s)
      粟津緑、飛彈麻里子
    • Organizer
      第51回日本小児腎臓病学会学術集会
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 葉酸は母体低栄養・メチル酸ドナー欠乏による尿管芽分岐・ネフロン数減少を改善する2016

    • Author(s)
      粟津緑、飛彈麻里子
    • Organizer
      第59回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Maternal nutrient restriction aggravates renal tubular necrosis and interstital fibrosis afeter unilateral ureteral obstruction in rat offspring.2015

    • Author(s)
      Mariko Hida, Tokiya Abe, Akinori Hahiguchi, and Midori Awazu
    • Organizer
      ASN, Kidnew Week 2015
    • Place of Presentation
      サンデイエゴ(米国)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Follic acid alleviates reduced ureteric branching and nephrogenesis induced by maternal undernutirition in rat embryonic kidney.2015

    • Author(s)
      Midori Awazu, Mariko Hida
    • Organizer
      ASN, Kidnew Week 2015
    • Place of Presentation
      サンデイエゴ(米国)
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 母体低栄養ラット片側尿管結紮モデルにおける尿細管壊死、間質線維化の悪化2015

    • Author(s)
      飛彈麻里子、阿部時生、橋口明典、粟津緑
    • Organizer
      日本小児腎臓病学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] DNAメチルトランスフェラーゼ1のラット後腎発生、母体低栄養による腎形成異常における役割2015

    • Author(s)
      粟津緑、飛彈麻里子
    • Organizer
      日本小児腎臓病学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎臓におけるDevelopmental Origins of Health and Disease オーバービュー・メカニズム2015

    • Author(s)
      粟津緑
    • Organizer
      第58会日本腎臓学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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