| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To adapt to the rapid formation and growth of fetal skeletons, the serum levels of phosphate is maintained to be much higher in the fetus than in the pregnant mothers. However, the mechanisms underlying the phosphate homeostasis in fetus remain obscure.
In the current study, to identify the molecules involved in phosphate homeostasis in fetus, we performed Agilent Expression Array analysis using the placentas of wild-type fetuses from hypophosphatemic Hyp mouse mothers and those from WT mouse mothers. Functional analyses are undergoing on the molecules whose expression was different between the groups. In addition, we investigated the effects of elevated extracellular inorganic phosphate on osteoblasts and revealed the possibility that FGF receptor might be involved in phosphate sensing.
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