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Spindle orientation control via caveolin1 and Ak2 in skin development

Research Project

Project/Area Number 15K09741
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionNagoya University (2017)
Kyoto University (2015-2016)

Principal Investigator

Matsumura Shigeru  名古屋大学, 医学系研究科, 特任講師 (60523511)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞分裂軸制御 / 脂質糖代謝 / AK2 / 細胞運命 / 脂質合成 / 細胞分裂軸
Outline of Final Research Achievements

It has been reported that spindle orientation control in skin basal cells has a pivotal role in skin development. Caveolin1, Ak2 and Pank2 are candidates, involved in spindle orientation control by our screen in adherent cultured cells. We hypothesized that these genes have a role in a common spindle orientation regulatory pathway, especially in metabolic pathway in sugar and lipids. However, although the inhibition of metabolic pathway resulted in spindle disregulation, we could not find a common pathway behind three candidate genes. We found that spindle misorientation in skin basal cells during embryonic skin development in caveolin1 ko mice. But we could not obtained Ak2 floxed homo mice at last and could not obtain any results if Ak2 regulates spindle orientation in skin development. To elucidate further insights, studies on more detailed analysis in metabolisms should be required.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1.2016

    • Author(s)
      Matsumura S., Kojidani T., Kamioka Y., Uchida S., Haraguchi T., Kimura A., and Toyoshima F.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11858-11858

    • DOI

      10.1038/ncomms11858

    • NAID

      120005774665

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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