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The role of epidermal Langerhans cells and apoptotic cells in the termination of UV-induced cutaneous inflammation

Research Project

Project/Area Number 15K09742
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKobe University

Principal Investigator

Fukunaga Atsushi  神戸大学, 医学部附属病院, 講師 (10467649)

Research Collaborator Hatakeyama Mayumi  
Washio Ken  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords紫外線 / 炎症 / ランゲルハンス細胞 / アポトーシス / 貪食 / 角化細胞 / 日焼け
Outline of Final Research Achievements

Skin disorders caused by ultraviolet are observed as "sunburn" as an acute reaction. "Sunburn" is a risk factor of developing skin cancer. In this study, we focused on the role of epidermal Langerhans cells (LCs) and the UV-induced apoptotic keratinocyte in the outermost layer of the skin in relation to the termination of the UV-induced cutaneous inflammation. This study demonstrated that LC and apoptotic keratinocytes plays a role in suppression of UV-induced cutaneous inflammation. The inflammatory suppression mechanism and signal are mediated by LC phagocytosis of apoptotic keratinocytes.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells.2017

    • Author(s)
      Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 9

    • DOI

      10.1161/jaha.117.007024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory role of langerhans cells and apoptotic keratinocytes in ultraviolet-B-induced cutaneous inflammation.2017

    • Author(s)
      Hatakeyama M, Fukunaga A, Washio K, Taguchi K, Oda Y, Ogura K, Nishigori C
    • Journal Title

      Journal of Immunology

      Volume: 199 Issue: 8 Pages: 2937-2947

    • DOI

      10.4049/jimmunol.1601681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017

    • Author(s)
      Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 37(1) Issue: 1 Pages: 66-74

    • DOI

      10.1161/atvbaha.116.308063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases2017

    • Author(s)
      Washio K, Fukunaga A, Onodera M, Hatakeyama M, Taguchi K, Ogura K, Horikawa T, Nishigori C.
    • Journal Title

      Journal of Dermatological Science

      Volume: 85 Issue: 2 Pages: 135-137

    • DOI

      10.1016/j.jdermsci.2016.11.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists2016

    • Author(s)
      Mayumi Hatakeyama, Atsushi Fukunaga, , Ken Washio, Kanako Ogura, Yozo Yamada, Tatsuya Horikawa, Chikako Nishigori
    • Journal Title

      Journal of Dermatological Science

      Volume: 82 Issue: 2 Pages: 137-139

    • DOI

      10.1016/j.jdermsci.2016.02.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 内因性光線過敏症(日光蕁麻疹、多形日光疹、慢性光線性皮膚炎)の新たな知見2017

    • Author(s)
      福永 淳
    • Organizer
      第116回日本皮膚科学会総会(教育講演23)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Antiinflammatory role of Langerhans cells and apoptotic keratinocytes in UVB-induced cutaneous inflammation2015

    • Author(s)
      Mayumi Hatakeyama, Atsushi Fukunaga, Ken Washio, Kumiko Taguchi, Chikako Nishigori
    • Organizer
      日本研究皮膚科学会第40回年次学術大会・総会
    • Place of Presentation
      岡山
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Book] 【自己と対峙する皮膚疾患の治療と病態-皮膚エリテマトーデス、中條-西村症候群を中心に】 (Part3.)皮膚の自己抗原を介在した免疫調節異常(皮膚の自己抗原を介在した免疫調節異常05) 光線過敏症と自己抗原(解説/特集)2017

    • Author(s)
      福永 淳
    • Total Pages
      105
    • Publisher
      Visual Dermatology, 秀潤社
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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