The role of epidermal Langerhans cells and apoptotic cells in the termination of UV-induced cutaneous inflammation

• Project/Area Number: 15K09742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: Fukunaga Atsushi 神戸大学, 医学部附属病院, 講師 (10467649)
• Research Collaborator: Hatakeyama Mayumi ; Washio Ken
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 紫外線 / 炎症 / ランゲルハンス細胞 / アポトーシス / 貪食 / 角化細胞 / 日焼け

Outline of Final Research Achievements

Skin disorders caused by ultraviolet are observed as "sunburn" as an acute reaction. "Sunburn" is a risk factor of developing skin cancer. In this study, we focused on the role of epidermal Langerhans cells (LCs) and the UV-induced apoptotic keratinocyte in the outermost layer of the skin in relation to the termination of the UV-induced cutaneous inflammation. This study demonstrated that LC and apoptotic keratinocytes plays a role in suppression of UV-induced cutaneous inflammation. The inflammatory suppression mechanism and signal are mediated by LC phagocytosis of apoptotic keratinocytes.

Research Products

• [Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells. (2017)
  • Author(s): Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
  • Journal Title: J Am Heart Assoc. Volume: 6 Issue: 9
  • DOI: 10.1161/jaha.117.007024
  • Peer Reviewed
• [Journal Article] Anti-inflammatory role of langerhans cells and apoptotic keratinocytes in ultraviolet-B-induced cutaneous inflammation. (2017)
  • Author(s): Hatakeyama M, Fukunaga A, Washio K, Taguchi K, Oda Y, Ogura K, Nishigori C
  • Journal Title: Journal of Immunology Volume: 199 Issue: 8 Pages: 2937-2947
  • DOI: 10.4049/jimmunol.1601681
  • Peer Reviewed
• [Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses. (2017)
  • Author(s): Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 37(1) Issue: 1 Pages: 66-74
  • DOI: 10.1161/atvbaha.116.308063
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases (2017)
  • Author(s): Washio K, Fukunaga A, Onodera M, Hatakeyama M, Taguchi K, Ogura K, Horikawa T, Nishigori C.
  • Journal Title: Journal of Dermatological Science Volume: 85 Issue: 2 Pages: 135-137
  • DOI: 10.1016/j.jdermsci.2016.11.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists (2016)
  • Author(s): Mayumi Hatakeyama, Atsushi Fukunaga, , Ken Washio, Kanako Ogura, Yozo Yamada, Tatsuya Horikawa, Chikako Nishigori
  • Journal Title: Journal of Dermatological Science Volume: 82 Issue: 2 Pages: 137-139
  • DOI: 10.1016/j.jdermsci.2016.02.001
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 内因性光線過敏症（日光蕁麻疹、多形日光疹、慢性光線性皮膚炎）の新たな知見 (2017)
  • Author(s): 福永 淳
  • Organizer: 第116回日本皮膚科学会総会（教育講演23）
  • Invited
• [Presentation] Antiinflammatory role of Langerhans cells and apoptotic keratinocytes in UVB-induced cutaneous inflammation (2015)
  • Author(s): Mayumi Hatakeyama, Atsushi Fukunaga, Ken Washio, Kumiko Taguchi, Chikako Nishigori
  • Organizer: 日本研究皮膚科学会第40回年次学術大会・総会
  • Place of Presentation: 岡山
  • Year and Date: 2015-12-11
• [Book] 【自己と対峙する皮膚疾患の治療と病態-皮膚エリテマトーデス、中條-西村症候群を中心に】 (Part3.)皮膚の自己抗原を介在した免疫調節異常(皮膚の自己抗原を介在した免疫調節異常05) 光線過敏症と自己抗原(解説/特集) (2017)
  • Author(s): 福永 淳
  • Total Pages: 105
  • Publisher: Visual Dermatology, 秀潤社