The role of epidermal Langerhans cells and apoptotic cells in the termination of UV-induced cutaneous inflammation
| Project/Area Number |
15K09742
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
Hatakeyama Mayumi
Washio Ken
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 紫外線 / 炎症 / ランゲルハンス細胞 / アポトーシス / 貪食 / 角化細胞 / 日焼け |
|---|
| Outline of Final Research Achievements |
Skin disorders caused by ultraviolet are observed as "sunburn" as an acute reaction. "Sunburn" is a risk factor of developing skin cancer. In this study, we focused on the role of epidermal Langerhans cells (LCs) and the UV-induced apoptotic keratinocyte in the outermost layer of the skin in relation to the termination of the UV-induced cutaneous inflammation. This study demonstrated that LC and apoptotic keratinocytes plays a role in suppression of UV-induced cutaneous inflammation. The inflammatory suppression mechanism and signal are mediated by LC phagocytosis of apoptotic keratinocytes.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells.2017
Author(s)
Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 9
DOI
Related Report
Peer Reviewed
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[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
Author(s)
Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 37(1)
Issue: 1
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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