Elucidation of the role of lipid rafts in the pathophysiology of pemphigus vulgaris

• Project/Area Number: 15K09748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: Saito Masataka 慶應義塾大学, 医学部(信濃町), 講師 (30306774)
• Co-Investigator(Kenkyū-buntansha): 山上 淳 慶應義塾大学, 医学部(信濃町), 講師 (80327618)
• Research Collaborator: KOWALCZYK AP 米国エモリー大学, 医学部, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 尋常性天疱瘡 / デスモゾーム / 脂質ラフト / 細胞内シグナル / デスモグレイン3 / エンドサイトーシス

Outline of Final Research Achievements

It was suggested that enlargement of the size of lipid rafts as a result of clustering of desmoglein (Dsg) 3 molecules was significant to function as a signaling platform in the pathogenesis of pemphigus vulgaris, although the relationship among desmosomal proteins other than Dgs3, cellular signaling molecules and lipid rafts is yet to be elucidated.