Regulatory mechanism of hair follicle stem cell quiescence by cell polariry protein aPKC
Project/Area Number |
15K09755
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Akita University |
Principal Investigator |
OSADA Shin-Ichi 秋田大学, 医学(系)研究科(研究院), 准教授 (00244484)
|
Co-Investigator(Kenkyū-buntansha) |
能登 舞 秋田大学, 医学部, 助教 (10738462)
|
Co-Investigator(Renkei-kenkyūsha) |
HIROSE Tomonori 横浜市立大学, 大学院医学系研究科, 講師 (10142027)
|
Research Collaborator |
SUZUKI Tomoko
KAGAYA Masami
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 細胞極性 / プロテインキナーゼC / aPKC / 創傷治癒 / 毛包幹細胞 / 毛包新生 / 細胞移動 / Wnt経路 / 休眠機構 / 脱毛 |
Outline of Final Research Achievements |
The isoforms of atypical protein kinase C (aPKC), aPKCζ and aPKCλ, regulate cell polarity and are expressed in the epidermis. Here, we addressed whether aPKCs are implicated in two major processes for maintaining epidermal homeostasis: cutaneous wound healing and wound-induced hair follicle neogenesis (WIHN). In epidermis-specific aPKCλ-knockout mice, wound healing was significantly retarded and WIHN was upregulated concomitantly with an increase in Wnt signaling. Conversely, wound healing and WIHN in aPKCζ-null mice were comparable to those in control littermates. These results represent the first evidence that aPKCλ, but not aPKCζ, is a key molecule linking cutaneous wound healing and WIHN.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Melanotic Malignant Melanoma in Oculocutaneous Albinism Type 4.2017
Author(s)
Ozaki S, Funasaka Y, Otsuka Y, Oyama S, Ito M, Osada SI, Ueno T, Okamura K, Hozumi Y, Suzuki T, Kawana S, Saeki H.
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Journal Title
Acta Derm Venereol.
Volume: 97
Issue: 2
Pages: 287-288
DOI
Related Report
Peer Reviewed
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[Journal Article] Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens2016
Author(s)
Otsuka Y, Ueno T, Yamase A, Ito M, Osada S, Kawana S, Funasaka Y, Teye K, Ishii N, Hashimoto T, Saeki H.
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Journal Title
J Dermatol
Volume: 43
Issue: 8
Pages: 944-946
DOI
Related Report
Peer Reviewed
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