| Project/Area Number |
15K09760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAMIKI Takeshi 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50401352)
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| Co-Investigator(Kenkyū-buntansha) |
河上 裕 慶應義塾大学, 医学部(信濃町), 教授 (50161287)
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| Co-Investigator(Renkei-kenkyūsha) |
YAGUCHI Tomonori 慶應義塾大学, 医学部, 講師 (40424163)
YOKOZEKI Hiroo 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90210608)
KATAYAMA Ichiro 大阪大学, 医学研究科, 教授 (80191980)
TANEMURA Atsushi 大阪大学, 医学研究科, 講師 (50457016)
KANEKO Yasuhiko 埼玉県立がんセンター, 臨床腫瘍研究所, 統括参与 (50373387)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 悪性黒色腫 / 分子標的治療 |
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| Outline of Final Research Achievements |
Previous studies indicate that AMP-related kinase NUAK2 participates in the proliferation and migration of melanoma cells. In this study, we identified the deletion of PTEN as a genetic aberration associated with the amplification of NUAK2. Furthermore, we showed that an increased expression of phospho-Akt(S473) was associated with NUAK2 expression. This study also showed that knockdown of NUAK2 reduces the expression of CDK2 and a CDK2 inhibitor sufficiently suppresses proliferation of NUAK2-amplified and PTEN-deleted melanoma cells.
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