Development of a novel molecular targeted therapy against acral melanomas
Project/Area Number |
15K09760
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
NAMIKI Takeshi 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50401352)
|
Co-Investigator(Kenkyū-buntansha) |
河上 裕 慶應義塾大学, 医学部(信濃町), 教授 (50161287)
|
Co-Investigator(Renkei-kenkyūsha) |
YAGUCHI Tomonori 慶應義塾大学, 医学部, 講師 (40424163)
YOKOZEKI Hiroo 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90210608)
KATAYAMA Ichiro 大阪大学, 医学研究科, 教授 (80191980)
TANEMURA Atsushi 大阪大学, 医学研究科, 講師 (50457016)
KANEKO Yasuhiko 埼玉県立がんセンター, 臨床腫瘍研究所, 統括参与 (50373387)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 悪性黒色腫 / 分子標的治療 |
Outline of Final Research Achievements |
Previous studies indicate that AMP-related kinase NUAK2 participates in the proliferation and migration of melanoma cells. In this study, we identified the deletion of PTEN as a genetic aberration associated with the amplification of NUAK2. Furthermore, we showed that an increased expression of phospho-Akt(S473) was associated with NUAK2 expression. This study also showed that knockdown of NUAK2 reduces the expression of CDK2 and a CDK2 inhibitor sufficiently suppresses proliferation of NUAK2-amplified and PTEN-deleted melanoma cells.
|
Report
(4 results)
Research Products
(9 results)
-
[Presentation] NUAK2 is over-expressed and DNA copy number is increased in acral melanoma: its significance on the survival of patients2017
Author(s)
Nojima K, Hayashi M, Funazumi M, Ishikawa M, Kaneko Y, Kawaguchi M, Suzuki T, Tanemura A, Katayama I, Mori T, Yamazaki N, Yokozeki H, Hearing VJ, Namiki T
Organizer
47th Annual Meeting of the European Society for Dermatologic Research, SALZBURG 2017
Related Report
Int'l Joint Research
-
[Presentation] NUAK2 is over-expressed and DNA copy number is increased in acral melanoma: its significance on the survival of patients2017
Author(s)
Nojima K, Hayashi M, Funazumi M, Ishikawa M, Kaneko Y, Kawaguchi M, Suzuki T, Tanemura A, Katayama I, Mori T, Yamazaki N, Yokozeki H, Hearing VJ, Namiki T
Organizer
42nd Annual Meeting of the Japanese Society for Investigative Dermatology, KOCHI 2017
Related Report
Int'l Joint Research
-
-
-
-
-
-
-