| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Here, to elucidate the possible role of D-dopachrome tautomerase (D-DT) in photocarcinogenesis, the acute and chronic effects of UVB in the skin were examined using D-DT transgenic (Tg) and wild-type (WT) mice. D-DT Tg mice skin showed higher levels of D-DT protein expression without irradiation. However, following UVB exposure, D-DT protein expression dramatically increased in comparison with that of WT mice. Increased incidence of tumorigenesis was observed in the Tg than WT mice following chronic UVB irradiation. Next, it was also clarified whether the acceleration of photo-induced carcinogenesis in the Tg mice was mediated by the inhibition of apoptosis. The epidermis derived from the D-DT Tg mice showed less substantially decreased levels of p53 after acute UVB exposure in comparison with the WT mice. These results suggest that chronic UVB exposure enhances D-DT production, which may inhibit the p53-dependent apoptotic processes and thereby induce photocarcinogenesis in the skin.
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