• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of the effect on dermatitis by immunological imbalance due to reduced number of regulatory T cells

Research Project

Project/Area Number 15K09765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKyoto University

Principal Investigator

Nomura Takashi  京都大学, 医学研究科, 特定講師 (60346054)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords皮膚免疫 / 免疫制御 / アレルギー / 制御性T細胞 / 皮膚炎 / アトピー性皮膚炎 / 円形脱毛症
Outline of Final Research Achievements

Although etiology of atopic dermatitis, psoriasis, and collagen diseases is not fully clarified, it is partly explained by excessively activated immune system. Such over-activation is inhibited by special lymphocytes called regulatory T cells. In this study, we used contact dermatitis mouse model, IgE-dependent chronic allergic inflammatory mouse model, alopecia areata mouse model, and atopic dermatitis mouse model in order to analyze the severity of dermatitis when the number of regulatory T cells were transiently decreased. We found that the decrease of regulatory T cells in the induction phase enhanced contact dermatitis and IgE dependent chronic allergic inflammation in mice. We will continue to examine using alopecia areata model mouse and atopic dermatitis spontaneous model mouse.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Percutaneous exposure to high-dose hapten induces systemic immunosuppression through the inhibition of dendritic cell migration2016

    • Author(s)
      Saito K, Kitoh A, Hanakawa S, Nomura T, Miyachi Y, Kabashima K
    • Journal Title

      Jornal of Dermatological Science

      Volume: 81 Issue: 2 Pages: 136-40

    • DOI

      10.1016/j.jdermsci.2015.11.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Coexistence of cutaneous phosphaturic mesenchymal tumour and postoperative hypoparathyroidism2016

    • Author(s)
      Iwata, M. Nomura, T. Endo, Y. Inoue, N. Fujisawa, A. Tanioka, M. Yasoda, A. Ohara, M. Imanishi, Y. Matsui, M. Miyachi, Y. Kabashima, K.
    • Journal Title

      European Journal of Dermatology

      Volume: 26 Issue: 3 Pages: 303-304

    • DOI

      10.1684/ejd.2016.2741

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness2016

    • Author(s)
      Nomura, T. Katoh, M. Yamamoto, Y. Miyachi, Y. Kabashima, K.
    • Journal Title

      Journal of Dermatology

      Volume: 43 Issue: 8 Pages: 919-927

    • DOI

      10.1111/1346-8138.13287

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Eosinophilic pustular folliculitis: Trends in therapeutic options2016

    • Author(s)
      Nomura, T. Katoh, M. Yamamoto, Y. Miyachi, Y. Kabashima, K.
    • Journal Title

      Journal of Dermatology

      Volume: 43 Pages: 847-849

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi