Study of the effect on dermatitis by immunological imbalance due to reduced number of regulatory T cells

• Project/Area Number: 15K09765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyoto University
• Principal Investigator: Nomura Takashi 京都大学, 医学研究科, 特定講師 (60346054)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 皮膚免疫 / 免疫制御 / アレルギー / 制御性T細胞 / 皮膚炎 / アトピー性皮膚炎 / 円形脱毛症

Outline of Final Research Achievements

Although etiology of atopic dermatitis, psoriasis, and collagen diseases is not fully clarified, it is partly explained by excessively activated immune system. Such over-activation is inhibited by special lymphocytes called regulatory T cells. In this study, we used contact dermatitis mouse model, IgE-dependent chronic allergic inflammatory mouse model, alopecia areata mouse model, and atopic dermatitis mouse model in order to analyze the severity of dermatitis when the number of regulatory T cells were transiently decreased. We found that the decrease of regulatory T cells in the induction phase enhanced contact dermatitis and IgE dependent chronic allergic inflammation in mice. We will continue to examine using alopecia areata model mouse and atopic dermatitis spontaneous model mouse.

Research Products

• [Journal Article] Percutaneous exposure to high-dose hapten induces systemic immunosuppression through the inhibition of dendritic cell migration (2016)
  • Author(s): Saito K, Kitoh A, Hanakawa S, Nomura T, Miyachi Y, Kabashima K
  • Journal Title: Jornal of Dermatological Science Volume: 81 Issue: 2 Pages: 136-40
  • DOI: 10.1016/j.jdermsci.2015.11.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Coexistence of cutaneous phosphaturic mesenchymal tumour and postoperative hypoparathyroidism (2016)
  • Author(s): Iwata, M. Nomura, T. Endo, Y. Inoue, N. Fujisawa, A. Tanioka, M. Yasoda, A. Ohara, M. Imanishi, Y. Matsui, M. Miyachi, Y. Kabashima, K.
  • Journal Title: European Journal of Dermatology Volume: 26 Issue: 3 Pages: 303-304
  • DOI: 10.1684/ejd.2016.2741
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness (2016)
  • Author(s): Nomura, T. Katoh, M. Yamamoto, Y. Miyachi, Y. Kabashima, K.
  • Journal Title: Journal of Dermatology Volume: 43 Issue: 8 Pages: 919-927
  • DOI: 10.1111/1346-8138.13287
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Eosinophilic pustular folliculitis: Trends in therapeutic options (2016)
  • Author(s): Nomura, T. Katoh, M. Yamamoto, Y. Miyachi, Y. Kabashima, K.
  • Journal Title: Journal of Dermatology Volume: 43 Pages: 847-849
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant