| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Although etiology of atopic dermatitis, psoriasis, and collagen diseases is not fully clarified, it is partly explained by excessively activated immune system. Such over-activation is inhibited by special lymphocytes called regulatory T cells. In this study, we used contact dermatitis mouse model, IgE-dependent chronic allergic inflammatory mouse model, alopecia areata mouse model, and atopic dermatitis mouse model in order to analyze the severity of dermatitis when the number of regulatory T cells were transiently decreased. We found that the decrease of regulatory T cells in the induction phase enhanced contact dermatitis and IgE dependent chronic allergic inflammation in mice. We will continue to examine using alopecia areata model mouse and atopic dermatitis spontaneous model mouse.
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