Study toward the complete therapy of palmoplantar keratoderma

• Project/Area Number: 15K09768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka Ohtani University (2016-2017); Kagawa University (2015)
• Principal Investigator: Yoneda Kozo 大阪大谷大学, 薬学部, 教授 (60260626)
• Co-Investigator(Kenkyū-buntansha): 窪田 泰夫 香川大学, 医学部, 教授 (10126047) ; 中井 浩三 香川大学, 医学部附属病院, 講師 (40363204)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 薬物治療学 / 掌蹠角化症 / 分子遺伝学 / 皮膚科学 / 臨床薬理学 / コネキシン26 / GJB2

Outline of Final Research Achievements

This study is finding the ultimate curative drug for palmoplantar keratoderma. The cost for creating disease model cells is far cheaper than creating knock mouse. We created the stable transformants expressing wild type connexin 26 protein and mutant connexin 26 protein. Next, the signal transduction was analyzed in both transformants. We are going to find candidate drugs which inhibit abnormal proliferation and keratinization in stable transformants expressing mutant connexin 26 protein.

Research Products

• [Journal Article] Localized nodular pemphigoid. (2018)
  • Author(s): Yoneda K, Ishii N, Nakai K, Kubota Y and Hashimoto T
  • Journal Title: Int J Dermatol Volume: 57 Issue: 5 Pages: 587-589
  • DOI: 10.1111/ijd.13889
  • Peer Reviewed / Open Access
• [Journal Article] IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice. (2017)
  • Author(s): Nakai K, He YY, Nishiyama F, Naruse F, Haba R, Kushida Y, Katsuki N, Moriue T, Yoneda K, Kubota Y.
  • Journal Title: Sci Rep. Volume: 29 Issue: 1 Pages: 12473-12473
  • DOI: 10.1038/s41598-017-12756-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypokeratosis of multiple Bowen’s disease of the palms. (2017)
  • Author(s): Nakai K, Yoneda K, Moriue J, Moriue T and Kubota Y
  • Journal Title: Dermatol Sin Volume: 35 Issue: 2 Pages: 100-101
  • DOI: 10.1016/j.dsi.2016.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Coccygeal pad associated with neurosyphilis (2016)
  • Author(s): Yoneda K and Kubota Y
  • Journal Title: J Eur Aca Derm Venereol Volume: 30 Issue: 6 Pages: 1039-1041
  • DOI: 10.1111/jdv.13096
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comorbidity of dermatofibromas and mucinous nevus (2016)
  • Author(s): Sasaki T, Yoneda K (equally contributed), Yokoi I, Moriue J, Demitsu T and Kubota Y
  • Journal Title: Int J Dermatol Volume: 55 Issue: 1
  • DOI: 10.1111/ijd.13015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inherited ichthyosis: syndromic forms (2016)
  • Author(s): Yoneda K
  • Journal Title: J Dermatol Volume: 43 Issue: 3 Pages: 252-263
  • DOI: 10.1111/1346-8138.13284
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Case of a self-inflicted facial ulcer that improved after sepsis (2016)
  • Author(s): Nakai K, Yoneda K, Moriue J, Moriue T and Kubota Y
  • Journal Title: J Dermatol Volume: 43 Issue: 5 Pages: 576-577
  • DOI: 10.1111/1346-8138.13244
  • Peer Reviewed / Acknowledgement Compliant