The development of novel immunotherapy utilizing iPS-cell derived myeloid lines against malignant melanoma

• Project/Area Number: 15K09772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: FUKUSHIMA SATOSHI 熊本大学, 大学院生命科学研究部(医), 准教授 (50398210)
• Co-Investigator(Renkei-kenkyūsha): IHN HIRONOBU 熊本大学, 大学院生命科学研究部, 教授 (20282634) ; JINNIN MASATOSHI 和歌山県立医科大学, 医学部, 教授 (60401048)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: がん免疫療法 / 悪性黒色腫 / iPS細胞 / マクロファージ / インターフェロン / IL-15 / NK細胞 / サイトカイン / 免疫療法 / メラノーマ / 免疫細胞療法 / 細胞移入療法 / 腹膜播種

Outline of Final Research Achievements

We have established iPS-cell derived myeloid cell lines. iPS-cell derived macrophages (iPS-MP) can be differentiated from them. The efficacy of iPS-MP against mouse melanoma was analyzed. We used the mice, tumor and iPS cells from same genetic background. The mice was C57BL6, so the mice has normal immune system. We observed the same efficacy of IFN-βintroduced iPS-MP as immunodeficiency mice. Furthermore, we established IL-15 introduced iPS-MP(iPS-MP-IL=15). iPS-MP-IL=15 showed the synergic effect upon the iPS-MP-IFN-β.

Research Products

• [Int'l Joint Research] The University of Chicago/University of California(米国)
• [Int'l Joint Research] Hospital of Zurich(スイス)
• [Journal Article] Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts (2018)
  • Author(s): Sawamura Soichiro、Jinnin Masatoshi、Inoue Kuniko、Yamane Keitaro、Honda Noritoshi、Kajihara Ikko、Makino Takamitsu、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: J Dermatol Sci. Volume: 90 Issue: 1 Pages: 52-59
  • DOI: 10.1016/j.jdermsci.2017.12.017
  • Peer Reviewed
• [Journal Article] Dabrafenib and trametinib combination therapy safely performed in a patient with metastatic melanoma after severe liver toxicity due to vemurafenib. (2018)
  • Author(s): Shimada S, Fukushima S, Niimori D, Miyashita A, Setoyama H, Sasaki Y, Ihn H.
  • Journal Title: The Journal of Dermatology Volume: 0 Issue: 6 Pages: 0-0
  • DOI: 10.1111/1346-8138.14206
  • Peer Reviewed / Open Access
• [Journal Article] Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma (2017)
  • Author(s): Egashira Sho、Jinnin Masatoshi、Ajino Manami、Shimozono Naoki、Okamoto Sayo、Tasaki Yukino、Hirano Ayaka、Ide Maho、Kajihara Ikko、Aoi Jun、Harada Miho、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12654-12654
  • DOI: 10.1038/s41598-017-12836-z
  • Peer Reviewed
• [Journal Article] The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation. (2017)
  • Author(s): Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H.
  • Journal Title: Eur J Dermatol. Volume: 27 Issue: 5 Pages: 464-471
  • DOI: 10.1684/ejd.2017.3084
  • Peer Reviewed
• [Journal Article] Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget's disease (2017)
  • Author(s): Nakamura Yuki、Kajihara Ikko、Yamada-Kanazawa Saori、Maeda-Otsuka Saki、Johno Takamitsu、Aoi Jun、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi、Jinnin Masatoshi、Ihn Hironobu
  • Journal Title: Drug Discoveries & Therapeutics Volume: 11 Issue: 3 Pages: 152-155
  • DOI: 10.5582/ddt.2017.01022
  • NAID: 130005875038
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] Transforming growth factor β inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis. (2017)
  • Author(s): Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Y, Asano Y, Ihn H.
  • Journal Title: Exp Dermatol Volume: 印刷中 Issue: 11 Pages: 1139-1143
  • DOI: 10.1111/exd.13366
  • Peer Reviewed
• [Journal Article] Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients. (2017)
  • Author(s): Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: J Dermatol. Volume: 印刷中 Issue: 8 Pages: 927-931
  • DOI: 10.1111/1346-8138.13838
  • Peer Reviewed
• [Journal Article] AT-rich Interaction Domain-containing Protein 3B is a New Tumour Marker for Melanoma. (2017)
  • Author(s): Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H.
  • Journal Title: Acta Derm Venereol. Volume: 1 Issue: 1 Pages: 112-114
  • DOI: 10.2340/00015555-2449
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers. (2017)
  • Author(s): Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N1, Makino K1, Kajihara I, Fukushima S, Ihn H
  • Journal Title: European Journal of Dermatology Volume: 1 Issue: 1 Pages: 20-27
  • DOI: 10.1684/ejd.2016.2906
  • Peer Reviewed
• [Journal Article] Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1 , MYB , Cep6 , and CCND1 probes in Japanese patients (2017)
  • Author(s): Aoi Jun、Fukushima Satoshi、Jinnin Masatoshi、Ihn Hironobu
  • Journal Title: Dermatologica Sinica, Volume: 35 Issue: 4 Pages: 213-214
  • DOI: 10.1016/j.dsi.2017.04.002
  • Peer Reviewed / Open Access
• [Journal Article] Bullous dermatosis on legs of elderly: A new clinical entity? (2017)
  • Author(s): Ishibashi Takayuki、Jinnin Masatoshi、Kajihara Ikko、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: Drug Discoveries & Therapeutics Volume: 11 Issue: 6 Pages: 346-348
  • DOI: 10.5582/ddt.2017.01067
  • NAID: 130006308074
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan (2017)
  • Author(s): Suzuki Shigeaki、Ishikawa Nobuhisa、Konoeda Fumie、Seki Nobuhiko、Fukushima Satoshi、Takahashi Kikuko、Uhara Hisashi、Hasegawa Yoshikazu、Inomata Shinichiro、Otani Yasushi、Yokota Kenji、Hirose Takashi、Tanaka Ryo、Suzuki Norihiro、Matsui Makoto
  • Journal Title: Neurology Volume: 89 Issue: 11 Pages: 1127-1134
  • DOI: 10.1212/wnl.0000000000004359
  • Peer Reviewed
• [Journal Article] Inhibition of HSP90 exerts anti-tumor effect on angiosarcoma: Involvement of VEGF signaling pathway. (2017)
  • Author(s): Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.
  • Journal Title: Br J Dermatol. Volume: 印刷中 Issue: 2 Pages: 456-469
  • DOI: 10.1111/bjd.15303
  • Peer Reviewed
• [Journal Article] Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (2017)
  • Author(s): Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H.
  • Journal Title: Australas J Dermatol. Volume: 印刷中 Issue: 3
  • DOI: 10.1111/ajd.12510
  • Peer Reviewed
• [Journal Article] The expression of miR-124 increases in aged skin to cause cell senescence and it decreases in squamous cell carcinoma (2016)
  • Author(s): Harada M, Jinnin M, Wang Z, Hirano A, Tomizawa Y, Kira T, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: BioScience Trends Volume: 10 Issue: 6 Pages: 454-459
  • DOI: 10.5582/bst.2016.01102
  • NAID: 130005295759
  • ISSN: 1881-7815, 1881-7823
  • Peer Reviewed
• [Journal Article] Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations. (2016)
  • Author(s): Egashira S, Jinnin M, Harada M, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: An Bras Dermatol. Volume: 6 Pages: 748-753
  • Peer Reviewed
• [Journal Article] Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients. (2016)
  • Author(s): Nonomura Y, Otsuka A, Nakashima C, Seidel JA, Kitoh A, Dainichi T, Nakajima S, Sawada Y, Matsushita S, Aoki M, Takenouchi T, Fujimura T, Hatta N, Koreeda S, Fukushima S, Honda T, Kabashima K.
  • Journal Title: Oncoimmunology Volume: 5(12) Issue: 12 Pages: e1248327-e1248327
  • DOI: 10.1080/2162402x.2016.1248327
  • Peer Reviewed
• [Journal Article] Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma. (2016)
  • Author(s): Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y.
  • Journal Title: Oncoimmunology. Volume: - Issue: 9 Pages: e1204507-e1204507
  • DOI: 10.1080/2162402x.2016.1204507
  • NAID: 120007100149
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression. (2016)
  • Author(s): Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: Rheumatology (Oxford) Volume: 56 Issue: 1 Pages: 145-155
  • DOI: 10.1093/rheumatology/kew336
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. (2016)
  • Author(s): Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Morinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Taketomi Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34690-34690
  • DOI: 10.1038/srep34690
  • NAID: 120006534970
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma. (2016)
  • Author(s): Wang Z, Nakamura K, Jinnin M, Kudo H, Goto M, Era T, Kira T, Nakashima T, Fukushima S, Ihn H.
  • Journal Title: J Dermatol Sci Volume: 84 Issue: 2 Pages: 186-196
  • DOI: 10.1016/j.jdermsci.2016.08.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts. (2016)
  • Author(s): Nakamura K, Jinnin M, Harada M, Kudo H, Nakayama W, Inoue K, Ogata A, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: J Dermatol Sci. Volume: 1 Issue: 1 Pages: 30-39
  • DOI: 10.1016/j.jdermsci.2016.06.013
  • Peer Reviewed / Open Access
• [Journal Article] Myasthenic crisis and polymyositis induced by one dose of nivolumab. (2016)
  • Author(s): Kimura T, Fukushima S, Miyashita A, Aoi J, Jinnin M, Kosaka T, Ando Y, Matsukawa M, Inoue H, Kiyotani K, Park JH, Nakamura Y, Ihn H.
  • Journal Title: Cancer Sci. Volume: 7 Issue: 7 Pages: 1055-1058
  • DOI: 10.1111/cas.12961
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cell division cycle-associated protein 1 as a new melanoma-associated antigen. (2016)
  • Author(s): Tokuzumi A, Fukushima S, Miyashita A, Nakahara S, Kubo Y, Yamashita J, Harada M, Nakamura K, Kajihara I, Jinnin M, Ihn H.
  • Journal Title: J Dermatol. Volume: 12 Issue: 12 Pages: 1399-1405
  • DOI: 10.1111/1346-8138.13436
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cytokine expression profiles in the sera of cutaneous squamous cell carcinoma patients (2016)
  • Author(s): Yamada S, Jinnin M, Kajihara I, Nakashima T, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: Drug Discoveries & Therapeutics Volume: 10 Issue: 3 Pages: 172-176
  • DOI: 10.5582/ddt.2016.01032
  • NAID: 130005167361
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] Symptomless Pulmonary Cryptococcosis in a Psoriatic Arthritis Patient during Infliximab Therapy. (2016)
  • Author(s): Yamada S, Kajihara I, Johno T, Fukushima S, Jinnin M, Masunaga A, Kohrogi H, Ihn H.
  • Journal Title: Ann Dermatol. Volume: 2 Issue: 2 Pages: 269-270
  • DOI: 10.5021/ad.2016.28.2.269
  • Peer Reviewed / Open Access
• [Journal Article] Frequency of level II and III axillary nodes metastases in patients with positive sentinel lymph nodes in melanoma: a multi-institutional study in Japan. (2016)
  • Author(s): Tsutsumida A, Takahashi A, Namikawa K, Yamazaki N, Uhara H, Teramoto Y, Takenouchi T, Fukushima S, Yokota K, Uehara J, Matsushita S, Shibayama Y, Hatta N, Masui Y, Uchi H, Fujisawa Y, Ogata D.
  • Journal Title: Int J Clin Oncol. Volume: 4 Issue: 4 Pages: 796-800
  • DOI: 10.1007/s10147-015-0944-y
  • Peer Reviewed
• [Journal Article] Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons. (2016)
  • Author(s): Miyashita A, Fukushima S, Nakahara S, Kubo Y, Tokuzumi A, Yamashita J, Aoi J, Haruta M, Senju S, Nishimura Y, Jinnin M, Ihn H
  • Journal Title: Cancer Immunol Res Volume: 3 Issue: 3 Pages: 248-258
  • DOI: 10.1158/2326-6066.cir-15-0096
  • Peer Reviewed / Open Access
• [Journal Article] The role of PSMB9 upregulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and systemic lupus erythematosus. (2016)
  • Author(s): Nakamura K, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Kajihara I, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: Br J Dermatol. Volume: 5 Issue: 5 Pages: 1030-1041
  • DOI: 10.1111/bjd.14385
  • Peer Reviewed
• [Journal Article] Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization. (2016)
  • Author(s): Wang Z, Jinnin M, Nakamura K, Harada M, Kudo H, Nakayama W, Inoue K, Nakashima T, Honda N, Fukushima S, Ihn H.
  • Journal Title: Exp Dermatol. Volume: 25 Issue: 2 Pages: 131-136
  • DOI: 10.1111/exd.12900
  • Peer Reviewed
• [Journal Article] Transcription factor LSF (TFCP2) inhibits melanoma growth. (2016)
  • Author(s): Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M.
  • Journal Title: Oncotarget. Volume: 19 Issue: 3 Pages: 2739-2790
  • DOI: 10.18632/oncotarget.6230
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma. (2016)
  • Author(s): Ichigozaki Y, Fukushima S, Jinnin M, Miyashita A, Nakahara S, Tokuzumi A, Yamashita J, Kajihara I, Aoi J, Masuguchi S, Zhongzhi W, Ihn H.
  • Journal Title: Exp Dermatol. Volume: 25 Pages: 67-69
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enhanced CCR9 expression levels in psoriatic skin are associated with poor clinical outcome to infliximab treatment. (2015)
  • Author(s): Koga A, Kajihara I, Yamada S, Makino K, Ichihara A, Aoi J, Makino T, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: J Dermatol. Volume: 43 Issue: 5 Pages: 522-5
  • DOI: 10.1111/1346-8138.13178
  • Peer Reviewed / Open Access
• [Journal Article] microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma (2015)
  • Author(s): Minami Inoue, Masatoshi Jinnin MD, PhD*, Zhongzhi Wang PhD, Kayo Nakamura MD, Kuniko Inoue MD, PhD, Asako Ichihara MD, PhD, Chikako Moriya MD, PhD, Keisuke Sakai MD, PhD, Satoshi Fukushima MD, PhD andHironobu Ihn MD, PhD
  • Journal Title: International Journal of Dermatology Volume: 24 Issue: 7 Pages: 1-5
  • DOI: 10.1111/ijd.12958
  • Peer Reviewed
• [Journal Article] Investigation of FOXM1 as a Potential New Target for Melanoma. (2015)
  • Author(s): Miyashita A, Fukushima S, Nakahara S, Yamashita J, Tokuzumi A, Aoi J, Ichihara A, Kanemaru H, Jinnin M, Ihn H.
  • Journal Title: PLoS One. Volume: 10 Issue: 12 Pages: e0144241-e0144241
  • DOI: 10.1371/journal.pone.0144241
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum concentrations of Flt-3 ligand in rheumatic diseases (2015)
  • Author(s): Nakamura K, Nakatsuka N, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Inoue K, Fukushima S, Ihn H.
  • Journal Title: BioScience Trends Volume: 9 Issue: 5 Pages: 342-349
  • DOI: 10.5582/bst.2015.01121
  • NAID: 130005109609
  • ISSN: 1881-7815, 1881-7823
  • Peer Reviewed / Open Access
• [Journal Article] NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma. (2015)
  • Author(s): Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, Tomizawa Y, Etoh-Kira T, Kajihara I, Harada M, Fukushima S, Ihn H.
  • Journal Title: Cancer Res. Volume: 75 Issue: 21 Pages: 4458-4465
  • DOI: 10.1158/0008-5472.can-15-0418
  • Peer Reviewed
• [Journal Article] Serum miR-124 up-regulation as a disease marker of toxic epidermal necrolysis. (2015)
  • Author(s): Sato S, Ichihara A, Jinnin M, Izuno Y, Fukushima S, Ihn H.
  • Journal Title: Eur J Dermatol. Volume: 25 Issue: 5 Pages: 457-462
  • DOI: 10.1684/ejd.2015.2621
  • Peer Reviewed
• [Journal Article] EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin. (2015)
  • Author(s): Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H.
  • Journal Title: J Immunol. Volume: 195 Issue: 8 Pages: 3565-3573
  • DOI: 10.4049/jimmunol.1402362
  • Peer Reviewed / Open Access
• [Journal Article] Biweekly gemcitabine therapy induces complete remission in cutaneous angiosarcoma resistant to multiple anticancer drugs. (2015)
  • Author(s): Kajihara I, Maeda S, Yamada S, Izumi K, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: J Dermatol. Volume: 42 Issue: 12 Pages: 1197-1198
  • DOI: 10.1111/1346-8138.13077
  • Peer Reviewed
• [Journal Article] Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma. (2015)
  • Author(s): Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
  • Journal Title: Cancer Immunol Res. Volume: 3 Issue: 12 Pages: 1356-1363
  • DOI: 10.1158/2326-6066.cir-14-0180
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients. (2015)
  • Author(s): Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H.
  • Journal Title: J Dermatol Sci. Volume: 80 Issue: 1 Pages: 33-37
  • DOI: 10.1016/j.jdermsci.2015.07.012
  • Peer Reviewed / Open Access
• [Journal Article] Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin. (2015)
  • Author(s): Wang Z, Jinnin M, Kobayashi Y, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Makino T, Fukushima S, Inagaki Y, Ihn H.
  • Journal Title: J Dermatol Sci. Volume: 79 Issue: 3 Pages: 268-278
  • DOI: 10.1016/j.jdermsci.2015.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma. (2015)
  • Author(s): Kumasaka MY, Yajima I, Iida M, Takahashi H, Inoue Y, Fukushima S, Ihn H, Takeda K, Naito Y, Yoshikawa T, Kato M.
  • Journal Title: Am J Cancer Res. Volume: 15 Pages: 1117-1123
  • Peer Reviewed
• [Journal Article] Crizotinib-associated erythema multiforme in a lung cancer patient (2015)
  • Author(s): Sawamura S, Kajihara I, Ichihara A, Fukushima S, Jinnin M, Yamaguchi E, Kohrogi H, Ihn H.
  • Journal Title: Drug Discoveries & Therapeutics Volume: 9 Issue: 2 Pages: 142-143
  • DOI: 10.5582/ddt.2015.01019
  • NAID: 130005071482
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed / Open Access
• [Journal Article] Platelet-rich plasma therapy is effective for the treatment of refractory skin ulcers in patients with systemic sclerosis. (2015)
  • Author(s): Kanemaru H, Kajihara I, Yamanaka K, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: Mod Rheumatol. Volume: 25 Issue: 4 Pages: 660-661
  • DOI: 10.3109/14397595.2014.924204
  • Peer Reviewed
• [Journal Article] Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma. (2015)
  • Author(s): Yamazaki N, Kiyohara Y, Uhara H, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Tokudome T.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 76 Issue: 5 Pages: 994-1004
  • DOI: 10.1007/s00280-015-2873-x
  • Peer Reviewed / Open Access
• [Journal Article] Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma. (2015)
  • Author(s): Yamazaki N, Uhara H, Fukushima S, Uchi H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K, Okuyama R, Otsuka Y, Tokudome T.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 76 Pages: 969-975
  • Peer Reviewed
• [Presentation] 皮膚悪性腫瘍 up to date メラノーマバイオマーカー開発は急務である！ (2017)
  • Author(s): 福島聡
  • Organizer: 第80回日本皮膚科学会 東京支部学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2017-02-11
  • Invited
• [Presentation] ニボルマブにより重症筋無力症、筋炎、心筋炎を発症した症例 (2017)
  • Author(s): 福島 聡、木村俊宏、宮下 梓、青井 淳、神人正寿、井上博之、清谷一馬、Jae-Hyun Park、中村祐輔、尹 浩信
  • Organizer: 第86回日本皮膚科学会山梨地方会
• [Presentation] 染毛剤の吸入によるアナフィラキシーショックの1例 (2017)
  • Author(s): 福島 聡、緒方亜紀、本多教稔、神人正寿、尹 浩信
  • Organizer: 第66回日本アレルギー学会総会
• [Presentation] Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolmab against melanomas (2017)
  • Author(s): Fukushima S, Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Nakamura Y.
  • Organizer: 第21回日本がん免疫学会総会
• [Presentation] インフリキシマブで多発性筋炎を発症した尋常性乾癬の1例 (2017)
  • Author(s): 福島 聡、梶原一亨、宮下 梓、浅尾香恵、藤澤明彦、浅尾香恵、神人正寿、尹 浩信。
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] Immune biomarkers to predict response of nivolimab, intratumoral gene expression and T cell receptor repertoire analsys. (2017)
  • Author(s): Fukushima S, Inoue H, Park J, Kiyotani K, Kiniwa Y, Fujisawa Y, Kato H, Asai J, Yokota K, Ihn H, Nakamura Y.
  • Organizer: 47 th Annual ESDR Meeting
  • Int'l Joint Research
• [Presentation] Serum levels of soluble PD-L1 in patients with metastatic melanoma treated with anti-PD-1 antibodies. (2017)
  • Author(s): Fukushima S, Inamori Y, Kubo Y, Nakahara S, Miyashita A, Tsuruta M, Tokuzumi A, Niimori D, Jinnin M, Ihn H.
  • Organizer: 42 th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab (2016)
  • Author(s): Satoshi Fukushima, Hiroyuki Inoue, Jae-Hyun Park, Kazuma Kiyotani, Makda Zewde, Azusa Miyashita, Masatoshi Jinnin, Yukiko Kiniwa, Yasuhiro Fujisawa, Hiroshi Kato, Jun Asai, Kenji Yokota, Hironobu Ihn, Yusuke Nakamura
  • Organizer: 第41回日本研究皮膚科学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-12-09
• [Presentation] T cell receptor repertoire analysis in the melanoma patient with myasthenic crisis and polymyositis induced by nivolumab (2016)
  • Author(s): Satoshi Fukushima, Toshihiro Kimura, Azusa Miyashita, Jun Aoi, Masatoshi Jinnin, Hiroyuki Inoue, Kazuma Kiyotani, Jae-Hyun Park, Yusuke Nakamura, Hironobu Ihn
  • Organizer: 第45回日本免疫学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2016-12-05
• [Presentation] Myasthenic crisis, polymyositis and myocarditis induced by one dose of nivolumab (2016)
  • Author(s): Satoshi Fukushima, Toshihiro Kimura, Azusa Miyashita, Jun Aoi, Masatoshi Jinnin, Hiroyuki Inoue, Kazuma Kiyotani, Jae-Hyun Park, Yusuke Nakamura, Hironobu Ihn
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: Karuizawa Prince Hotel Wes
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] Sacran benefits impaired human skin as an artificial barrier in and on the skin (2016)
  • Author(s): Yuki Sagawa, Satoshi Fukushima, Keiichi Motoyama, Taishi Higashi Hidetoshi Arima, Moeko Doi, Shigeyoshi Momose, Takumi Tanaka, Taeko Mizutani, Hironobu Ihn, Yuri Okano
  • Organizer: IFSCC2016
  • Place of Presentation: walt disney world dolphin resort, Orlando
  • Year and Date: 2016-09-30
  • Int'l Joint Research
• [Presentation] 乾癬に対する分子標的治療戦略 (2016)
  • Author(s): 福島聡
  • Organizer: 第４８回日本臨床分子形態学会総会・学術集会
  • Place of Presentation: くまもと県民交流館パレア
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] T cell receptor repertoire analysis in the melanoma patient with myasthenic crisis and polymyositis induced by nivolumab (2016)
  • Author(s): Satoshi Fukushima, Toshihiro Kimura, Azusa Miyashita, Jun Aoi, Masatoshi Jinnin, Hiroyuki Inoue, Kazuma Kiyotani, Jae-Hyun Park, Yusuke Nakamura, Hironobu Ihn
  • Organizer: 46th Annual ESDR Meeting 2016
  • Place of Presentation: Technical University of Munich
  • Year and Date: 2016-09-07
  • Int'l Joint Research
• [Presentation] ニボルマブにより重症筋無力症、多発性筋炎、心筋炎を発症したメラノーマにおけるTCRレパトワ解析 (2016)
  • Author(s): 福島聡、木村俊寛、宮下梓、青井淳、神人正寿、井上博之、清谷一馬、Jae-Hyun Park、中村祐輔、尹浩信
  • Organizer: 第20回がん免疫学会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2016-07-27
• [Presentation] メラノーマと樹状細胞 (2016)
  • Author(s): 福島聡
  • Organizer: 第115回日本皮膚科学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-06-03
  • Invited
• [Presentation] SLN生検をreviewする (2016)
  • Author(s): 福島聡
  • Organizer: 第32回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 鹿児島県民交流センター
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] Immunotherapy with human iPS-cell derived myeloid cell lines producing Type I interferons against metastatic melanoma (2015)
  • Author(s): Azusa Miyashita, Satoshi Fukushima, Satoru Senju, Yasuharu Nishimura, Masatoshi Jinnin, Hironobu Ihn
  • Organizer: 第44会日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（札幌）
  • Year and Date: 2015-11-18
• [Presentation] 遺伝子改変ヒトiPS細胞由来マクロファージ様細胞を用いた進行期悪性黒色腫の免疫療法 (2015)
  • Author(s): 宮下 梓、福島 聡、中原智史、徳澄亜紀、久保陽介、千住 覚、西村泰治、神人正寿、尹 浩信
  • Organizer: 第43回日本臨床免疫学会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2015-10-22
• [Presentation] メラノーマ治療新時代の幕開け 「イムノチェックポイント阻害剤」 (2015)
  • Author(s): 福島聡
  • Organizer: 第67回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 長崎新聞文化ホール（長崎）
  • Year and Date: 2015-10-17
• [Presentation] Immunotherapy with human iPS-cell derived myeloid cell lines producing type I interferons against metastatic melanoma. (2015)
  • Author(s): Azusa Miyashita, Satoshi Fukushima, Satoru Senju, Yasuharu Nishimura, Masatoshi Jinnin, Hironobu Ihn
  • Organizer: International Conference of Cancer Immunology and Macrophages
  • Place of Presentation: 東京大学 伊藤国際学術センター内 伊藤謝恩ホール（東京）
  • Year and Date: 2015-07-09
  • Int'l Joint Research
• [Presentation] 悪性黒色腫の臨床および基礎的研究の進歩の秘訣 【バイオマーカーUPDATE】 (2015)
  • Author(s): 福島聡
  • Organizer: 第３１回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-07-03
• [Book] 臨床皮膚科 最近のトピックス2017 IV 皮膚疾患治療のポイント 《進行期悪性黒色腫の治療戦略》 (2017)
  • Author(s): 福島聡
  • Total Pages: 4
  • Publisher: 医学書院
• [Book] Monthly Book Derma. 知っておきたい分子標的薬の最新情報 メラノーマに対する分子標的薬② （BRAF阻害剤、MEK阻害剤） (2017)
  • Author(s): 福島聡
  • Total Pages: 5
  • Publisher: 全日本病院出版社
• [Book] 専門医でも聞きたい皮膚科診療100の質問 《母斑・腫瘍》 56. オプジーボはメラノーマ患者を救う？ (2017)
  • Author(s): 福島聡
  • Total Pages: 1
  • Publisher: メディカルレビュー社
• [Book] 月刊《皮膚病診療》vol. 39 増刊号 皮膚科救急診療マニュアル 福島聡 タイトル：悪性黒色腫 (2017)
  • Author(s): 福島聡
  • Total Pages: 1
  • Publisher: 協和企画
• [Book] 『がん免疫療法』2017年3月創刊号「Clinical Trials & Study Design」 (2017)
  • Author(s): 福島聡
  • Total Pages: 72
  • Publisher: メディカルレビュー社
• [Book] 臨床皮膚科2017年増刊号（71巻５号） 最近のトピックス2017 IV 皮膚疾患治療のポイント 《進行期悪性黒色腫の治療戦略》 (2017)
  • Author(s): 福島聡
  • Publisher: 医学書院
• [Book] カレントテラピー vol.34 No.4 メラノーマ ー基礎から最新薬物療法までー 6. メラノーマにおける薬物療法 ２）免疫療法 (2016)
  • Author(s): 福島聡
  • Total Pages: 93
  • Publisher: ライフメディコム
• [Book] カレントテラピー vol.34 No.4 メラノーマ ー基礎から最新薬物療法までー 6. メラノーマにおける薬物療法 ２）免疫療法 (2016)
  • Author(s): 福島 聡
  • Publisher: ライフメディコム