| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Resident epidermal T cells of the murine skin express an invariant γδ T-cell receptor (Vγ3 TCR) that recognizes an undetermined self ligand expressed on epidermal keratinocytes, and the TCR stimulation triggers rapid production of IL-13. In contrast, their fetal thymic precursors (Vγ3 TCR+ fetal thymocytes) produce IFN-γ but not IL-13. Analyses of the cytokine production pattern by the Vγ3 TCR+ cells during development revealed that Vγ3 TCR+ cells acquire IL-13-producing capacity in the perinatal epidermis. Resident epidermal T cells in γδ T-cell-deficient mice that express diverse αβ TCRs but cannot recognize the self ligand on epidermal keratinocytes produced IFN-γ but not IL-13. Therefore, TCR-mediated signals might be involved in the differentiation of epidermal T cells into IL-13-producing cells.
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