Molecular mechanism by which circadian rhythm affects development and refractory of allergic disorders.

• Project/Area Number: 15K09776
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KATOH NORITO 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30244578)
• Co-Investigator(Kenkyū-buntansha): 峠岡 理沙 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80464585) ; 八木田 和弘 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90324920)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アレルギー / アレルギー反応 / 概日リズム / 接触過敏反応 / 新生児免疫寛容

Outline of Final Research Achievements

The purpose of this study was to investigate the effects of circadian rhythm disruption on the development of immune tolerance by the perturbation of light environment. Mice were kept under constant light (LL) or light-dark (LD) conditions, and hapten was applied at 2days after birth. Six weeks later, hapten was reapplied to abdominal skin, followed by hapten application to ear skin 5days later. The ear-swelling responses and cell infiltration into inflamed skin significantly increased in LL mice compared with those in LD mice. The percentage and the number of Foxp3+-regulatory T cells notably decreased in inflamed skin and draining lymph nodes of LL mice compared with that in LD mice. Loss-of-function mutation of a key circadian gene, Bmal1, also exacerbated the ear-swelling responses and cell infiltration into inflamed skin in mice. These results suggest that circadian rhythm may be implicated in immune tolerance development in allergic inflammation.

Research Products

• [Journal Article] Influence of topical steroids on intraocular pressure in patients with atopic dermatitis (2018)
  • Author(s): Tamagawa-Mineoka Risa、Yasuoka Naoko、Ueta Mayumi、Katoh Norito
  • Journal Title: Allergology International Volume: 67 Issue: 3 Pages: 388-391
  • DOI: 10.1016/j.alit.2018.01.004
  • NAID: 130007420677
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice (2018)
  • Author(s): Ueta M, Hamuro J, Nishigaki H, Nakamura N, Shinomiya K, Mizushima K, Hitomi Y, Tamagawa-Mineoka R, Yokoi N, Naito Y, Tokunaga K, Katoh N, Sotozono C, Kinoshita S.
  • Journal Title: Allergy Volume: 73 Issue: 2 Pages: 395-404
  • DOI: 10.1111/all.13308
  • Peer Reviewed / Open Access
• [Journal Article] Immediate-type allergic reactions to local anesthetics (2018)
  • Author(s): Nakamura Naomi、Tamagawa-Mineoka Risa、Masuda Koji、Katoh Norito
  • Journal Title: Allergology International Volume: 67 Issue: 1 Pages: 160-161
  • DOI: 10.1016/j.alit.2017.07.003
  • NAID: 130006322104
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Constant light exposure impairs immune tolerance development in mice. (2017)
  • Author(s): Mizutani H, Tamagawa-Mineoka R, Minami Y, Yagita K, Katoh N
  • Journal Title: Journal of Dermatological Science Volume: 86 Issue: 1 Pages: 63-70
  • DOI: 10.1016/j.jdermsci.2016.12.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical Usefulness of the Platelet-to Lymphocyte Ratio in Patients with Angiosarcoma of the Face and Scalp (2017)
  • Author(s): Suzuki Gen、Yamazaki Hideya、Aibe Norihiro、Masui Koji、Sasaki Naomi、Shimizu Daisuke、Kimoto Takuya、Asai Jun、Wada Makoto、Komori Satoshi、Katoh Norito、Yamada Kei
  • Journal Title: International Journal of Molecular Sciences Volume: 18 Issue: 11 Pages: 2402-2402
  • DOI: 10.3390/ijms18112402
  • Peer Reviewed
• [Journal Article] The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation (2017)
  • Author(s): Yasuike Risa、Tamagawa-Mineoka Risa、Ueta Mayumi、Nakamura Naomi、Kinoshita Shigeru、Katoh Norito
  • Journal Title: Journal of Dermatological Science Volume: 88 Issue: 2 Pages: 184-191
  • DOI: 10.1016/j.jdermsci.2017.07.017
  • Peer Reviewed
• [Journal Article] Patch testing in patients with recurrent vesicular hand eczema (2017)
  • Author(s): Tamagawa-Mineoka R, Nakamura N, Ueda S, Masuda K, Katoh N.
  • Journal Title: Allergology International Volume: 66 Issue: 4 Pages: 632-633
  • DOI: 10.1016/j.alit.2017.03.006
  • NAID: 130006179513
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Podoplanin expression in peritumoral keratinocytes predicts aggressive behavior in extramammary Paget's disease. (2017)
  • Author(s): Cho Z, Konishi E, Kanemaru M, Isohisa T, Arita T, Kawai M, Tsutsumi M, Mizutani H, Takenaka H, Ozawa T, Tsuruta D, Katoh N, Asai J.
  • Journal Title: J Dermatol Sci. Volume: 印刷中 Issue: 1 Pages: 29-35
  • DOI: 10.1016/j.jdermsci.2017.03.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Continuous dosing versus interrupted therapy with ixekizumab: an integrated analysis of two phase 3 trials in psoriasis. (2017)
  • Author(s): Blauvelt A, Papp KA, Sofen H, Augustin M, Yosipovitch G, Katoh N, Mrowietz U, Ohtsuki M, Poulin Y, Shrom D, Burge R, See K, Mallbris L, Gordon KB.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: - Issue: 6 Pages: 1004-1013
  • DOI: 10.1111/jdv.14163
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum IL-21 levels are elevated in atopic dermatitis patients with acute skin lesions. (2017)
  • Author(s): Mizutani H, Tamagawa-Mineoka R, Nakamura N, Masuda K, Katoh N.
  • Journal Title: Allergology International Volume: 66 Pages: 440-444
  • Peer Reviewed / Open Access
• [Journal Article] Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma. (2017)
  • Author(s): Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y.
  • Journal Title: Oncoimmunology Volume: 5(9)
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Platelets regulate the migration of keratinocytes via podoplanin/CLEC-2 signaling during cutaneous wound healing in mice. (2016)
  • Author(s): Asai J, Hirakawa S, Sakabe J, Kishida T, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N.
  • Journal Title: Am J Pathol Volume: 186 Issue: 1 Pages: 101-108
  • DOI: 10.1016/j.ajpath.2015.09.007
  • Peer Reviewed / Open Access
• [Journal Article] Clinical practice guidelines for the management of atopic dermatitis 2016. (2016)
  • Author(s): Saeki H, Nakahara T, Tanaka A, Kabashima K, Sugaya M, Murota H, Ebihara T, Kataoka Y, Aihara M, Etoh T, Katoh N.
  • Journal Title: J Dermatol Volume: 印刷中 Issue: 10 Pages: 1154-1159
  • DOI: 10.1111/1346-8138.13392
  • Peer Reviewed / Open Access
• [Journal Article] 308 nm excimer light therapy for alopecia universalis that is resistant to other treatments: a clinical study of 11 patients. (2016)
  • Author(s): Arakawa Y, Nomiyama T, Katoh N.
  • Journal Title: J Dermatol Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Poor adherence to oral and topical medication in 3096 dermatological patients as assessed by the Morisky Medication Adherence Scale-8. (2015)
  • Author(s): Furue M, Onozuka D, Takeuchi S, Murota H, Sugaya M, Masuda K, Hiragun T, Kaneko S, Saeki H, Shintani Y, Tsunemi Y, Abe S, Kobayashi M, Kitami Y, Tanioka M, Imafuku S, Abe M, Inomata N, Morisky DE, Katoh N.
  • Journal Title: Br J Dermatol. Volume: 172 Issue: 1 Pages: 272-275
  • DOI: 10.1111/bjd.13377
  • Peer Reviewed / Open Access
• [Journal Article] Comparative Cut-off Value Setting of Pruritus Intensity in Visual Analogue Scale and Verbal Rating Scale. (2015)
  • Author(s): Kido-Nakahara M, Katoh N, Saeki H, Mizutani H, Hagihara A, Takeuchi S, Nakahara T, Masuda K, Tamagawa-Mineoka R, Nakagawa H, Omoto Y, Matsubara K, Furue M.
  • Journal Title: Acta Derm Venereol Volume: 95 Issue: 3 Pages: 345-346
  • DOI: 10.2340/00015555-1972
  • Peer Reviewed / Open Access
• [Journal Article] Poor adherence to medication as assessed by the Morisky Medication Adherence Scale-8 and low satisfaction with treatment in 237 psoriasis patients. (2015)
  • Author(s): Saeki H, Imafuku S, Abe M, Shintani Y, Onozuka D, Hagihara A, Katoh N, Murota H, Takeuchi S, Sugaya M, Tanioka M, Kaneko S, Masuda K, Inomata N, Hiragun T, Kitami Y, Tsunemi Y, Abe S, Kobayashi M, Morisky DE, Furue M.
  • Journal Title: J Dermatol Volume: 42 Issue: 4 Pages: 367-372
  • DOI: 10.1111/1346-8138.12804
  • Peer Reviewed / Open Access
• [Journal Article] Transient improvement of urticaria induces poor adherence as assessed by Morisky Medication Adherence Scale-8. (2015)
  • Author(s): Kaneko S, Masuda K, Hiragun T, Inomata N, Furue M, Onozuka D, Takeuchi S, Murota H, Sugaya M, Saeki H, Shintani Y, Tsunemi Y, Abe S, Kobayashi M, Kitami Y, Tanioka M, Imafuku S, Abe M, Hagihara A, Morisky DE, Katoh N.
  • Journal Title: J Dermatol Volume: 42 Issue: 11 Pages: 1078-1082
  • DOI: 10.1111/1346-8138.12971
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of socioeconomic status of Japanese patients with atopic dermatitis showing poor medical adherence and reasons for drug discontinuation. (2015)
  • Author(s): Murota H, Takeuchi S, Sugaya M, Tanioka M, Onozuka D, Hagihara A, Saeki H, Imafuku S, Abe M, Shintani Y, Kaneko S, Masuda K, Hiragun T, Inomata N, Kitami Y, Tsunemi Y, Abe S, Kobayashi M, Morisky DE, Furue M, Katoh N.
  • Journal Title: J Dermatol Sci Volume: 79 Issue: 3 Pages: 279-287
  • DOI: 10.1016/j.jdermsci.2015.05.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adherence to oral and topical medication in 445 patients with tinea pedis as assessed by the Morisky Medication Adherence Scale-8. (2015)
  • Author(s): Tsunemi Y, Abe S, Kobayashi M, Kitami Y, Onozuka D, Hagihara A, Takeuchi S, Murota H, Sugaya M, Masuda K, Hiragun T, Kaneko S, Saeki H, Shintani Y, Tanioka M, Imafuku S, Abe M, Inomata N, Morisky DE, Furue M, Katoh N.
  • Journal Title: Eur J Dermatol Volume: 25 Issue: 6 Pages: 570-577
  • DOI: 10.1684/ejd.2015.2650
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contact sensitivity in patients with recalcitrant atopic dermatitis. (2015)
  • Author(s): Tamagawa-Mineoka R, Masuda K, Ueda S, Nakamura N, Hotta E, Hattori J, Minamiyama R, Yamazaki A, Katoh N.
  • Journal Title: J Dermatol Volume: E-pub Issue: 7 Pages: 720-722
  • DOI: 10.1111/1346-8138.12866
  • Peer Reviewed / Open Access
• [Journal Article] PDK1 is a potential therapeutic target against angiosarcoma cells. (2015)
  • Author(s): Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N.
  • Journal Title: J Dermatol Sci Volume: 78 Issue: 1 Pages: 44-50
  • DOI: 10.1016/j.jdermsci.2015.01.015
  • Peer Reviewed / Open Access
• [Presentation] アトピー性皮膚炎の新規治療 (2017)
  • Author(s): 加藤則人
  • Organizer: 第116回日本皮膚科学会総会
  • Invited
• [Presentation] アレルギー性皮膚疾患 (2017)
  • Author(s): 加藤則人
  • Organizer: 第51回日本アレルギー学会専門医教育セミナー
  • Invited
• [Presentation] エキスパートが選ぶトピックス 2017－皮膚疾患 (2017)
  • Author(s): 加藤則人
  • Organizer: 第4回日本アレルギー学会総合アレルギー講習会
  • Invited
• [Presentation] H1-antihistamines in atopic dermatitis-Does it really work? (2015)
  • Author(s): Katoh N
  • Organizer: Atopic Dermatitis Symposium-controversies and updates.
  • Place of Presentation: Singapore, Singapore.
  • Year and Date: 2015-11-13
  • Int'l Joint Research / Invited
• [Presentation] Does patient with atopic dermatitis benefit from the use of H1-antihistamines? (2015)
  • Author(s): Katoh N
  • Organizer: CK-CARE International Research Forum for Atopic Dermatitis.
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2015-06-28
  • Int'l Joint Research / Invited
• [Book] Evolution of atopic dermatitis in the 21st century. (2017)
  • Author(s): Katoh N.
  • Total Pages: 381
  • Publisher: Springer
• [Book] Immunology of the skin. Basic and clinical sciences in skin immune responses. (2016)
  • Author(s): Tamagawa-Mineoka R, Katoh N.
  • Total Pages: 505
  • Publisher: Springer Japan
• [Book] From environmental factors to molecular opportunities (2016)
  • Author(s): Tamagawa-Mineoka R, Ueta M, Katoh N.
  • Publisher: Springer Science Books