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Toll-like receptor 3 increase chronic contact hypersensitivity induced by repeated application of hapten.

Research Project

Project/Area Number 15K09777
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Mineoka Risa  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80464585)

Co-Investigator(Kenkyū-buntansha) 上田 真由美  京都府立医科大学, 医学(系)研究科, 准教授 (60398386)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアトピー性皮膚炎 / Toll様受容体 / Toll様受容体3 / 自然免疫 / ハプテン / 接触過敏反応
Outline of Final Research Achievements

Accumulating evidence suggests that Toll-like receptor (TLR)-3 signaling is involved in non-infectious inflammatory reactions. The exact role of TLR3 in AD remains to be defined. The purpose of this study was to investigate the role of TLR3 in chronic contact hypersensitivity reactions induced by repeated elicitation, resembling the features of AD. Wild-type (WT) and Toll-like receptor 3 knockout (Tlr3 KO) mice were sensitized, and chronic contact hypersensitivity reactions were elicited in their ear skin via repeated application of a hapten, 2,4,6-trinitro-1-chlorobenzene (TNCB) or oxazolone. The Tlr3 KO mice exhibited less ear swelling, less leukocyte infiltration into the skin, and lower serum total IgE levels than WT mice after hapten challenge. The Tlr3 KO mice also displayed lower expression levels of inflammatory cytokines in their TNCB-treated ear skin than WT mice. The results showed that TLR3 deficiency suppressed the development of chronic contact hypersensitivity reactions.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation2017

    • Author(s)
      Yasuike Risa、Tamagawa-Mineoka Risa、Ueta Mayumi、Nakamura Naomi、Kinoshita Shigeru、Katoh Norito
    • Journal Title

      Journal of Dermatological Science

      Volume: 88 Issue: 2 Pages: 184-191

    • DOI

      10.1016/j.jdermsci.2017.07.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constant light exposure impairs immune tolerance development in mice.2017

    • Author(s)
      Mizutani H, Tamagawa-Mineoka R, Minami Y, Yagita K, Katoh N
    • Journal Title

      Journal of Dermatological Science

      Volume: 86 Issue: 1 Pages: 63-70

    • DOI

      10.1016/j.jdermsci.2016.12.016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Serum IL-21 levels are elevated in atopic dermatitis patients with acute skin lesions2017

    • Author(s)
      Mizutani H, Tamagawa-Mineoka R, Nakamura N, Masuda K, Katoh N
    • Journal Title

      Allergology International

      Volume: 66 Issue: 3 Pages: 440-444

    • DOI

      10.1016/j.alit.2016.10.010

    • NAID

      130005858803

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anaphylaxis caused by γ-cyclodextrin in sugammadex2016

    • Author(s)
      Hotta E, Tamagawa-Mineoka R, Masuda K, Taura M, Nakagawa Y, Kanehisa F, Tashima S, Katoh N.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 3 Pages: 356-358

    • DOI

      10.1016/j.alit.2016.02.013

    • NAID

      130005165873

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] アトピー性皮膚炎におけるToll-like receptor 3の 役割の解明2016

    • Author(s)
      峠岡理沙、上田真由美、加藤則人
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 362-368

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] The role of Toll-like receptor 3 in allergic and nonallergic skin inflammation2017

    • Author(s)
      Risa Tamagawa-Mineoka
    • Organizer
      2nd International Stevens-Johnson Syndrome Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2017-01-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Toll-like receptor 3 increase chronic contact hypersensitivity induced by repeated application of hapten2016

    • Author(s)
      Yasuike R, Tamagawa-Mineoka R, Ueta M, Nakamura N, Kinoshita S, Katoh N
    • Organizer
      The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Possible involvement of Toll-like receptor 3 in skin inflammation in Stevens-Johnson syndrome2016

    • Author(s)
      Risa Tamagawa-Mineoka
    • Organizer
      1st international SJS symposium
    • Place of Presentation
      京都
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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