Research on genetic factors of atopic dermatitis and psoriasis
| Project/Area Number |
15K09793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAEKI Hidehisa 日本医科大学, 大学院医学研究科, 大学院教授 (80235093)
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| Co-Investigator(Kenkyū-buntansha) |
玉利 真由美 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (00217184)
廣田 朝光 東京慈恵会医科大学, 医学部, 講師 (50435674)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アトピー性皮膚炎 / 乾癬 / 遺伝要因 |
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| Outline of Final Research Achievements |
We conducted an initial genome-wide association study (GWAS) and a replication study of psoriasis vulgaris (PsV) in the Japanese population (606 PsV cases and 2,052 controls). We identified significant associations of the single nucleotide polymorphisms (SNPs) with PsV risk at TNIP1 and the MHC region. By updating the HLA imputation reference panel of Japanese (n = 908), we demonstrated that HLA-A*02:07 was the most significant association with PsV. Our PsV GWAS in Japanese highlighted novel genetic architecture of PsV.
Sixty-five Japanese patients with psoriasis underwent anti-TNF-alpha treatment. We genotyped SNPs in TNFA, TNFRSF1B and TNFAIP3 genes which had been shown to be associated the response to anti-TNF-alpha treatment in Western countries. There was no significant association of these three SNPs with response to anti-TNF-alpha treatment in Japan. The difference between the two studies lies in the TNF-alpha inhibitors used.
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| Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎や乾癬の遺伝要因の解析で、亜型や治療反応性に注目した解析は極めて少なく、本研究の特色と言える。遺伝要因に関しては人種差があるため、欧米で行われた解析も日本人の集団で確認する必要がある。亜型や治療反応性で解析することにより、症例ごとにより適切な治療を選択することができるようになる点に本研究の意義がある。分子標的薬を用いた新しい治療の有効性は高いが費用も高いため、予め効果が期待できる患者を選別できれば、無駄な医療費を掛けずに済み、医療経済上の効果も大きい。
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Japanese guidelines for atopic dermatitis 20172017
Author(s)
Katayama I, Aihara M, Ohya Y, Saeki H, Shimojo N, Shoji S, Taniguchi M, Yamada H
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 230-247
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Clinical practice guidelines for the management of atopic dermatitis 2016.2016
Author(s)
Saeki H, Nakahara T, Tanaka A, Kabashima K, Sugaya M, Murota H, Ebihara T, Kataoka Y, Aihara M, Etoh T, Katoh N.
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Journal Title
J Dermatol
Volume: 印刷中
Issue: 10
Pages: 1154-1159
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Poor adherence to medication as assessed by the Morisky Medication Adherence Scale-8 and low satisfaction with treatment in 237 psoriasis patients.2015
Author(s)
Saeki H, Imafuku S, Abe M, Shintani Y, Onozuka D, Hagihara A, Katoh N, Murota H, Takeuchi S, Sugaya M, Tanioka M, Kaneko S, Masuda K, Inomata N, Hiragun T, Kitami Y, Tsunemi Y, Abe S, Kobayashi M, Morisky DE, Furue M.
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Journal Title
J Dermatol
Volume: 42
Issue: 4
Pages: 367-372
DOI
Related Report
Peer Reviewed / Open Access
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