Mechanisms of dermatitis and group 2 innate lymphoid cells (ILC2) activation
| Project/Area Number |
15K09796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Imai Yasutomo 兵庫医科大学, 医学部, 講師 (10529514)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
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| Research Collaborator |
JITSUKAWA Orie 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ILC2 / IL-33 / ２型自然リンパ球 / アトピー性皮膚炎 / 自然リンパ球 |
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| Outline of Final Research Achievements |
Interleukin-33 (IL-33) stimulates group 2 innate lymphoid cells (ILC2). We generated a transgenic mouse expressing IL-33 driven by a keratin-14 promoter (IL33Tg) and showed that IL-33 elicits atopic dermatitis (AD)-like inflammation with activation of ILC2 (Imai Y, PNAS, 2013; Imai Y, Sci Rep, 2017). When bone marrow from ILC2-lacking, RORα-deficient mice was transplanted into IL33Tg mice, the development of AD-like dermatitis was completely suppressed, and ILC2-derived cytokines/chemokines such as IL-5, IL-13, CCL5 and CCL11 were significantly reduced in the skin. These results suggest that IL-33-induced dermatitis is ILC2 dependent.
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Report
(4 results)
Research Products
(35 results)
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[Presentation] Atopic keratoconjunctivitis spontaneously develop in a mouse model of atopic dermatitis expressing the mouse interleukin-33 gene driven by a keratin 14 promoter2017
Author(s)
Imai Y, Hosotani Y, Kusakabe M, Ishikawa H, Yasuda K, Nagai M, Gomi F, Nakanishi K, Yoshimoto T, Nakamura T, Yamanishi K.
Organizer
Meeting of Society for Investigative Dermatology (SID 2017)
Related Report
Int'l Joint Research
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[Presentation] アトピー性角結膜炎モデルとしてのIL-33過剰産生遺伝子改変マウス(hK14-IL-33Tg)の有用性2017
Author(s)
細谷友雅, 今井康友, 石川裕人,安田好文, 永井諒, 實川織江,中西憲司,善本知広,中村隆宏,山西清文,五味文
Organizer
第121回日本眼科学会総会
Related Report
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