Androgen receptor target therapy of extramammary Paget's disease

• Project/Area Number: 15K09798
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kurume University
• Principal Investigator: KARASHIMA Tadashi 久留米大学, 医学部, 講師 (70211175)
• Co-Investigator(Kenkyū-buntansha): 古村 南夫 久留米大学, 医学部, 准教授 (10315070)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳房外ページェット病 / 男性ホルモン / アンドロゲン受容体 / 表皮成長因子受容体 / 上皮成長因子

Outline of Final Research Achievements

Although numerous cancer cell lines have already been established, to the best of our knowledge, the extramammary Paget’s disease (EMPD) cell line has not been established. EMPD cells also express glandular differentiation markers including carcinoembryonic antigen. In this study, we established EMPD cell line (EMPE cell) from typical EMPD skin lesions of an 82-year-old male. Androgen receptor is expressed in EMPE cell, but not Her2/neu proteins. EMPE cell showed positive growth effect by androgen and also EGF. EMPE cells should be extremely useful in the future studies of EMPD.