Gene expression analysis in monozygotic twins discordant for schizophrenia and control twins

• Project/Area Number: 15K09800
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: Kakiuchi Chihiro 東京大学, 医学部附属病院, 准教授 (90342766)
• Research Collaborator: Nishimura Fumichika 東京大学
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 一卵性双生児不一致例 / mRNA発現 / リンパ芽球 / 網羅的mRNA発現解析

Outline of Final Research Achievements

Schizophrenia is a severe mental disorder of which molecular mechanisms must be clarified. If there were biological differences between the monozygotic twins discordant for the illness, the differences might be the clues. In this study, we showed the possibility that the differences of mRNA expression profiles in lymphoblastoid cells existed between the monozygotic twins discordant for schizophrenia, and further, we suggested DPYD and IGHM as the candidate genes for schizophrenia.