| Project/Area Number |
15K09803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 勝昭 浜松医科大学, 医学部, 准教授 (00285040)
横倉 正倫 浜松医科大学, 医学部, 助教 (00529399)
岩田 泰秀 浜松医科大学, 医学部附属病院, 講師 (10285025)
亀野 陽亮 浜松医科大学, 医学部附属病院, 助教 (40537255)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | うつ病 / 電気けいれん療法 / 脳内ミクログリア / 活性化ミクログリア / ブドウ糖代謝 / PET / fMRI / ミクログリア |
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| Outline of Final Research Achievements |
To elucidate the the effect of Electric Convulsive Therapy (ECT) on the depression, alteration of microglial activation in the brain of depressive patient were examined. Binding potential (BPND) of 2nd-generation translocator protein (TSPO) tracer [11C]DPA713 were measured before and after ECT in the brain of patient with treatment-resistant depression. Hamilton Rating Scale for Depression (HDS-R) score and Montgomery-Asberg Depression Scale (MADRS) were 16 and 24 before the ECT treatment, and 7 and 11 after treatment, respectively. [11C]DPA713 BPND in several brain regions, such as brain stem, thalamus, and several cortical areas are elevated. Because of the limited number of subject examined, we fail to find alteration of [11C]DPA713 BPND, microglial activation, before and after ECT, nor correlation between psychometric scores and [11C]DPA713 BPND. Further research is needed to elucidate the mechanism of remedial effect of ECT in the treatment of depression.
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