| Project/Area Number |
15K09805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe University |
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Principal Investigator |
Boku Shuken 神戸大学, 医学研究科, 講師 (60455665)
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| Co-Investigator(Kenkyū-buntansha) |
菱本 明豊 神戸大学, 医学研究科, 准教授 (50529526)
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| Co-Investigator(Renkei-kenkyūsha) |
Murai Toshiya 京都大学, 大学院医学研究科, 教授 (30335286)
Furuyashiki Tomoyuki 神戸大学, 大学院医学研究科, 教授 (20362478)
Izumi Takeshi 北海道大学, 大学院医学研究科, 講師 (60312360)
Toda Hiroyuki 防衛医科大学校, 医学部, 助教 (00610677)
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| Research Collaborator |
Hiroi Noboru アルバートアインシュタイン医科大学, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 幼少期ストレス / DNAメチル化 / 成体海馬神経細胞新生 / DNMT / 母子分離ストレス / miRNA / 海馬 |
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| Outline of Final Research Achievements |
1. We showed that some miRNA-related molecules may be involved in early life stress-induced increase of DNA methylation in adult hippocampal neural stem cell.
2. We showed that early life stress remarkably increased DNA methylation of gene region X with genome-wide analysis of DNA methylation. In addition, we showed that DNA methylation of gene region X may be associated with stress sensibility with behavioral analysis.
3. We are showing that DNA methylation may be associated with the assessment scale for early life stress in human subjects.
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