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Analysis of molecular pathophysiology of gender identity disorder using microarray method

Research Project

Project/Area Number 15K09806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOkayama University

Principal Investigator

Okahisa Yuko  岡山大学, 大学病院, 助教 (90583097)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords性同一性障害 / 臨床精神分子遺伝学
Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathophysiology of gender identity disorder. We conducted whole-genome analysis of 206 female-to-male trans-sexual individuals and 1557 control subjects using Japonica array but failed to identify pathogenesis of gender identity disorder. We intend to perform further research using larger samples.

Academic Significance and Societal Importance of the Research Achievements

病態の手掛かりがない性同一性障害について全ゲノム解析を行ったことは、病態解明に向けた有意義な取り組みであったと考える。今回の解析では病態の解明につながる結果は得られなかったが、この研究を手掛かりにより多くのサンプルでの全ゲノム解析やメタボローム解析を行い、病態解明につなげたい。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(28 results)

All 2019 2018 2017 2016 2015

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (14 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect2019

    • Author(s)
      Ikeda M,Takahashi A,Kamatani Y,Momozawa Y,Saito T,Kondo K,Shimasaki A,Kawase K,Sakusabe T,Iwayama Y,Toyota T,Wakuda T,Kikuchi M,Kanahara N,Yamamori H,Yasuda Y,Watanabe Y,Hoya S,Aleksic B,Kushima I,Arai H,Takaki M,Hattori K,Kunugi H,Okahisa Y,Ohnuma T,Ozaki N,Someya T,Hashimoto R,Yoshikawa T,Kubo M,Iwata N
    • Journal Title

      Schizophr Bull

      Volume: 印刷中 Pages: 824-834

    • DOI

      10.1093/schbul/sby140

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.2018

    • Author(s)
      Ikeda M, Shimasaki A, Takahashi A,et al.
    • Journal Title

      Mol Psychiatry.

      Volume: in press Pages: 639-647

    • DOI

      10.1038/mp.2016.259

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rare loss of function mutations in N-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility2018

    • Author(s)
      Yu Yanjie、Lin Yingni、Takasaki Yuto、Wang Chenyao、Kimura Hiroki、Xing Jingrui、Ishizuka Kanako、Toyama Miho、Kushima Itaru、Mori Daisuke、Arioka Yuko、Uno Yota、Shiino Tomoko、Nakamura Yukako、Okada Takashi、Morikawa Mako、Ikeda Masashi、Iwata Nakao、Okahisa Yuko、Takaki Manabu、Sakamoto Shinji、et al.
    • Journal Title

      Transl Psychiatry

      Volume: 8 Pages: 12-12

    • DOI

      10.1038/s41398-017-0061-y

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine.2018

    • Author(s)
      Takaki M, Kodama M, Mizuki Y, Kawai H, Yoshimura B, Kishimoto M, Sakamoto S, Okahisa Y, Yamada N.
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: 28(5) Pages: 610-619

    • DOI

      10.1016/j.euroneuro.2018.03.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia.2018

    • Author(s)
      Ishizuka K, Kimura H, Kushima I, Inada T, Okahisa Y, Ikeda M, Iwata N, Mori D, Aleksic B, Ozaki N.
    • Journal Title

      Psychiatr Genet

      Volume: 5 Pages: 90-93

    • DOI

      10.1097/ypg.0000000000000204

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders2017

    • Author(s)
      Ishizuka K、Fujita Y、Kawabata T、Kimura H、Iwayama Y、Inada T、Okahisa Y、Egawa J、Usami M、Kushima I、Uno Y、Okada T、Ikeda M、Aleksic B、Mori D、Someya To、Yoshikawa T、Iwata N、Nakamura H、Yamashita T、Ozaki N
    • Journal Title

      Transl Psychiatry

      Volume: 7

    • DOI

      10.1038/tp.2017.173

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility2017

    • Author(s)
      Kimura H、Fujita Y、Kawabata T、Ishizuka K、Wang C、Iwayama Y、Okahisa Y、Kushima I、Morikawa M、Uno Y、Okada T、Ikeda M、Inada T、Branko A、Mori D、Yoshikawa T、Iwata N、Nakamura H、Yamashita T、Ozaki N
    • Journal Title

      Transl Psychiatry

      Volume: 7

    • DOI

      10.1038/tp.2017.170

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis2017

    • Author(s)
      Mizuki Y, Takaki M, Sakamoto S, Okamoto S, Kishimoto M, Okahisa Y, Itoh M, Yamada N
    • Journal Title

      Int J Mol Sci.

      Volume: 18(1) Pages: 1-11

    • DOI

      10.3390/ijms18010067

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estimated cognitive decline in patients with schizophrenia: A multicenter study.2017

    • Author(s)
      Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 印刷中 Pages: 294-300

    • DOI

      10.1111/pcn.12474

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes.2016

    • Author(s)
      Sakamoto S, Takaki M, Okahisa Y, Mizuki Y, Inagaki M, Ujike H, Mitsuhashi T, Takao S, Ikeda M, Uchitomi Y, Iwata N, Yamada N.
    • Journal Title

      J Hum Genet.

      Volume: 61 Pages: 329-334

    • DOI

      10.1038/jhg.2015.153

    • NAID

      40020802866

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease2016

    • Author(s)
      Chikako Ikeda, Osamu Yokota, Shigeto Nagao, Hideki Ishizu, Etsuko Oshima, Masato Hasegawa, Yuko Okahisa, Seishi Terada, Norihito Yamada
    • Journal Title

      Brain Pathol.

      Volume: 印刷中 Pages: 488-505

    • DOI

      10.1111/bpa.12319

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.2015

    • Author(s)
      Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.
    • Journal Title

      Psychiatr Genet

      Volume: 25(4) Pages: 139-146

    • DOI

      10.1097/ypg.0000000000000090

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Difference in determinants of caregiver burden between amnestic mild cognitive impairment and mild Alzheimer's disease.2015

    • Author(s)
      Ikeda C, Terada S, Oshima E, Hayashi S, Okahisa Y, Takaki M, Inagaki M, Yokota O, Uchitomi Y.
    • Journal Title

      Psychiatry Research

      Volume: 226(1) Pages: 242-246

    • DOI

      10.1016/j.psychres.2014.12.055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels2015

    • Author(s)
      Sumiyoshi C, Harvey PD, Takaki M, Okahisa Y, Sato T, Sora I, Nuechterlein KH, Subotnik KL, Sumiyoshi T.
    • Journal Title

      Schizophrenia Res: Cognition

      Volume: 2 Pages: 105-112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] The relationship of N-methyl-D-aspartate receptor antibody and psychiatric disorders2018

    • Author(s)
      Kawai H, Sakamoto S, Kishimoto M, Okahisa Y, Takaki M, Yamada N
    • Organizer
      CINP 31st World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine2018

    • Author(s)
      Takaki M, Kodama M, Mizuki Y, Kawai H, Yoshimura B, Kishimoto M, Sakamoto S, Okahisa Y, Yamada N.
    • Organizer
      CINP 31st World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電気痙攣療法における発作の質に麻酔薬が与える影響の検討2016

    • Author(s)
      酒本真次, 藤原雅樹, 岸本真希子, 岡久祐子, 髙木学, 山田了士
    • Organizer
      第26回 日本臨床精神神経薬理学会
    • Place of Presentation
      大分
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 統合失調症患者において、アリピプラゾールへの切り替え方法が継続率に与える影響の検討2016

    • Author(s)
      大林芳明, 吉村文太, 酒本真次, 岸本真希子, 岡久祐子, 武田俊彦, 髙木学, 山田了士
    • Organizer
      第26回 日本臨床精神神経薬理学会
    • Place of Presentation
      大分
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 日中の仮眠と易怒性が初期症状であり早期診断が困難であった神経梅毒の一例2016

    • Author(s)
      寒川尚登, 岸本真希子, 岡久祐子, 大島悦子, 川田清宏, 山田了士, 田所功, 幡中典子, 太田康之, 阿部康二
    • Organizer
      第57回 中国・四国精神神経学会
    • Place of Presentation
      松山
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Expression Profiles and Neurocognitive/Social Functions as a Predictive Biomarker of Schizophrenia2016

    • Author(s)
      Okahisa Y, Sakamoto S, Kishimoto M, Takaki M, Yamada N.
    • Organizer
      10th International Conference on Early Psychosis
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] PDE4B 遺伝子が統合失調症の発症脆弱性と認知機能に与える影響2016

    • Author(s)
      酒本真次, 高木学, 岡本宗次郎, 岸本真希子, 岡久祐子, 大井一高, 橋本亮太, 山田了士
    • Organizer
      第38回 日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗NMDA受容体抗体が神経発達に及ぼす影響の検討2016

    • Author(s)
      岡本宗次郎, 酒本真次, 岸本真希子, 岡久祐子, 髙木学, 山田了士
    • Organizer
      第38回 日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Factors to predict work outcome in Japanese patients with schizophrenia: cutoff performances on measures of functional outcomes2016

    • Author(s)
      Sumiyoshi C, Takaki M, Okahisa Y, Sato T, Sora I, Harvey P.D, Nuechterlein K.H, Subotnik K.L, Sumiyoshi T.
    • Organizer
      5th Biennial Schizophrenia International Research Society Conference
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression profiles and social function as a predictive biomarker of schizophrenia : a pilot study2016

    • Author(s)
      Okahisa Y, Sakamoto S, Takaki M, Yamada N.
    • Organizer
      5th Biennial Schizophrenia International Research Society Conference
    • Place of Presentation
      Florence, Italy
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clozapineによる無顆粒球症の改善後に薬剤性過敏性症候群(DIHS)を来した一例2015

    • Author(s)
      原紘志、岡久祐子、酒本真次、川田清宏、高木学、山田了士
    • Organizer
      第56回中国・四国精神神経学会
    • Place of Presentation
      倉敷
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 統合失調症患者の認知機能障害に対するクロザピンの有効性の検討2015

    • Author(s)
      酒本真次、水木寛、岡久祐子、高木学、山田了士
    • Organizer
      第25回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Expression profiles and cognitive function as a predictive biomarker of schizophrenia : a pilot study2015

    • Author(s)
      Okahisa Y, Sakamoto S, Takaki M, Yamada N.
    • Organizer
      XXIIIRD World Congress of Psychiatric Genetics
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] NMDA受容体機能関連遺伝子と統合失調症患者の臨床的・社会的転帰との関連研究2015

    • Author(s)
      酒本真次、高木学、岡久祐子、水木寛、山田了士
    • Organizer
      第37回日本生物学的精神医学会 第45回日本神経精神薬理学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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