• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidating molecular mechanisms underlying stress vulnerability

Research Project

Project/Area Number 15K09807
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionYamaguchi University

Principal Investigator

UCHIDA Shusaku  山口大学, 医学部附属病院, 講師 (10403669)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsストレス / うつ病 / レジリエンス / 神経新生 / 海馬
Outline of Final Research Achievements

This study demonstrated the role of hippocampal neurogenesis in the development of stress vulnerability during adulthood in mice. To this end, we used two inbred mouse strain: C57Bl/6J (B6) and BALB/c (BALB) as stress-resilient and stress-vulnerable model, respectively. BALB mice had reduced hippocampal neurogenesis at postnatal day 28, when compared to B6 mice, suggesting that hippocampal neurogenesis during development may modulate stress response later in life. To test this possibility, we injected memantine which can enhance hippocampal neurogenesis in BALB mice and investigated chronic stress-induced behaviors. We found that BALB mice given memantine did not show any behavioral abnormality following chronic stress episode. These results suggest that hippocampal neurogenesis plays an important role in the development of stress vulnerability/resilience. We also found that stathmin-mediated microtubule dynamics may control stress response in adulthood.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement2018

    • Author(s)
      Uchida Shusaku、Shumyatsky Gleb P.
    • Journal Title

      Brain Res Bull

      Volume: in press Pages: 3-12

    • DOI

      10.1016/j.brainresbull.2018.02.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synaptically Localized Transcriptional Regulators in Memory Formation2018

    • Author(s)
      Uchida Shusaku、Shumyatsky Gleb P.
    • Journal Title

      Neuroscience

      Volume: 370 Pages: 4-13

    • DOI

      10.1016/j.neuroscience.2017.07.023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epigenetic mechanisms of major depression: Targeting neuronal plasticity2017

    • Author(s)
      Uchida Shusaku、Yamagata Hirotaka、Seki Tomoe、Watanabe Yoshifumi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Issue: 4 Pages: 212-227

    • DOI

      10.1111/pcn.12621

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレスに強い脳をつくる運動トレーニングの制御機構2017

    • Author(s)
      内田周作
    • Journal Title

      体育の科学

      Volume: 67 Pages: 315-319

    • Related Report
      2017 Annual Research Report
  • [Journal Article] うつ病におけるヒストン脱アセチル化酵素の役割と新たな治療薬創出の試み2017

    • Author(s)
      内田周作、渡邉義文
    • Journal Title

      精神医学

      Volume: 59 Pages: 1045-1054

    • NAID

      40021376653

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 注目の遺伝子 Sirtuin遺伝子2017

    • Author(s)
      内田周作
    • Journal Title

      分子精神医学

      Volume: 17 Pages: 63-65

    • Related Report
      2017 Annual Research Report
  • [Journal Article] CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene2017

    • Author(s)
      Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP.
    • Journal Title

      Cell Rep

      Volume: 18 Pages: 352-366

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice.2016

    • Author(s)
      Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y.
    • Journal Title

      J Neurosci.

      Volume: 36 Pages: 7253-7267

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior2016

    • Author(s)
      Naoko Abe-Higuchi, Shusaku Uchida, Hirotaka Yamagata, Fumihiro Higuchi, Teruyuki Hobara, Kumiko Hara, Ayumi Kobayashi, and Yoshifumi Watanabe
    • Journal Title

      Biological Psychiatry

      Volume: In press Issue: 11 Pages: 815-826

    • DOI

      10.1016/j.biopsych.2016.01.009

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory2016

    • Author(s)
      Martel G, Uchida S, Hevi C, Chevere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP
    • Journal Title

      J Neurosci

      Volume: 36 Issue: 4 Pages: 1185-1202

    • DOI

      10.1523/jneurosci.4541-14.2016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] うつ病・不安障害におけるサーチュインの役割と創薬への可能性2017

    • Author(s)
      内田周作
    • Organizer
      第39回日本生物学的精神医学会 第47回日本神経精神薬理合同年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 非コードRNAによる脳機能制御とその破綻による精神疾患2017

    • Author(s)
      内田周作
    • Organizer
      第113回日本精神神経学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Altered expression of long noncoding RNAs in patients with major depression2017

    • Author(s)
      關友恵、内田周作
    • Organizer
      北米神経科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MicroRNA profiling of the ventral hippocampus in stress-resilient and stress-susceptible mice2017

    • Author(s)
      内田周作
    • Organizer
      北米神経科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Genetic activation of stathmin impairs adult hippocampal neurogenesis, spinogenesis, and NMDA receptor-dependent memory2015

    • Author(s)
      Shusaku Uchida, Itzamarie Chevere-Torres, Charles Hevi, Gleb P. Shumyatsky
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] レジリエンスの視点からうつ病の発症・回復の分子メカニズムを理解する2015

    • Author(s)
      内田周作
    • Organizer
      生物学的精神医学会・神経精神薬理学会合同年会
    • Place of Presentation
      タワーホール船堀・東京都江戸川区
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] エピジェネティクスによるうつ病の分子・細胞基盤2015

    • Author(s)
      内田周作
    • Organizer
      生物学的精神医学会・神経精神薬理学会合同年会
    • Place of Presentation
      タワーホール船堀・東京都江戸川区
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi