Elucidating molecular mechanisms underlying stress vulnerability
| Project/Area Number |
15K09807
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UCHIDA Shusaku 山口大学, 医学部附属病院, 講師 (10403669)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ストレス / うつ病 / レジリエンス / 神経新生 / 海馬 |
|---|
| Outline of Final Research Achievements |
This study demonstrated the role of hippocampal neurogenesis in the development of stress vulnerability during adulthood in mice. To this end, we used two inbred mouse strain: C57Bl/6J (B6) and BALB/c (BALB) as stress-resilient and stress-vulnerable model, respectively. BALB mice had reduced hippocampal neurogenesis at postnatal day 28, when compared to B6 mice, suggesting that hippocampal neurogenesis during development may modulate stress response later in life. To test this possibility, we injected memantine which can enhance hippocampal neurogenesis in BALB mice and investigated chronic stress-induced behaviors. We found that BALB mice given memantine did not show any behavioral abnormality following chronic stress episode. These results suggest that hippocampal neurogenesis plays an important role in the development of stress vulnerability/resilience. We also found that stathmin-mediated microtubule dynamics may control stress response in adulthood.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene2017
Author(s)
Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP.
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Journal Title
Cell Rep
Volume: 18
Pages: 352-366
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice.2016
Author(s)
Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y.
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Journal Title
J Neurosci.
Volume: 36
Pages: 7253-7267
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory2016
Author(s)
Martel G, Uchida S, Hevi C, Chevere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP
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Journal Title
J Neurosci
Volume: 36
Issue: 4
Pages: 1185-1202
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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