• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the therapeutic biomarker in bipolar disorder using CNV and methylation of target genes of mood stabilizers

Research Project

Project/Area Number 15K09810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKibi International University (2017)
Kochi University (2015-2016)

Principal Investigator

Morinobu Shigeru  吉備国際大学, 保健医療福祉学部, 教授 (30191042)

Co-Investigator(Kenkyū-buntansha) 淵上 学  広島大学, 医歯薬保健学研究科(医), 助教 (40403571)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsBipolar disorder / GSK3beta / BDNF / Lithium / CNV / Biomarker / 双極性障害 / Copy Number Variation / Bipolar Disorder / リチウム / Copy Number Variant / 治療薬反応性
Outline of Final Research Achievements

Although it is known that lithium (Li) is effective in the treatment of bipolar disorders (BDs), a certain patient with BDs poorly responds to Li. It is hypothesized that structural genomic variations in the GSK 3 beta or BDNF gene may change the therapeutic efficacy of Li. One type of structural genomic variations is a copy number variation (CNV). So, we examined the rates of CNVs in GSK 3 beta and BDNF gene based on the Databases of Genomic Variations (DGV) in patients with BDs by quantitative real-time PCR. The therapeutic response to Li was evaluated by Alda Scale.
In the BDNF gene, while 5 BD patients were found to have 3 copies of exon IV region within nsv95132, there was no healthy subject having an amplified exon IV region. There was no significant difference in Alda Scale A between BD patients with 3 copies and 2 copies.These findings suggest that CNV within exon IV of the BDNF gene may not be involved in the therapeutic response to Li in patients with BD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 4 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] DNAメチル化を用いたうつ病診断バイオマーカーの開発2017

    • Author(s)
      森信繁
    • Journal Title

      生化学

      Volume: 印刷中

    • NAID

      40021119802

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] BDNF遺伝子のDNAメチル化を指標としたうつ病診療2016

    • Author(s)
      淵上学、森信繁
    • Journal Title

      Depression Frontier

      Volume: 2 Pages: 68-76

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] The potential use of histone deacetylase inhibitors in the treatment of depression2015

    • Author(s)
      Fuchikami M, Morinobu S, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 62 Pages: 00059-7

    • DOI

      10.1016/j.pnpbp.2015.03.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015

    • Author(s)
      Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
    • Journal Title

      Epigenetics

      Volume: 10(2) Issue: 2 Pages: 135-141

    • DOI

      10.1080/15592294.2014.1003743

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Efficacy of lithium and BDNF gene CNV in bipolar disorders2018

    • Author(s)
      Shigeru Morinobu
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] GSK3beta, BDNF遺伝子のCNVによる双極性障害のリチウム治療反応性の研究2017

    • Author(s)
      森信繁、須賀楓介、吉本啓一郎、沼田周助、高村祥吾、上村直人、下寺信次、大森哲郎
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エピジェネティクスからみたうつ病の病態メカニズム2015

    • Author(s)
      森信 繁
    • Organizer
      第12回日本うつ病学会総会
    • Place of Presentation
      京王プラザ、東京
    • Year and Date
      2015-07-17
    • Related Report
      2015 Research-status Report
    • Invited

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi