| Project/Area Number |
15K09814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Maekawa Motoko 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (50435731)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA Takeo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30249958)
OHNISHI Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (80373281)
TOYOSHIMA Manabu 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90582750)
SHIMAMOTO Chie 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90755117)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | オリゴデンドロサイト / RXR / 統合失調症 / 核内受容体 |
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| Outline of Final Research Achievements |
We hypothesized that specific nuclear receptors regulate expressions of multiple oligodendrocyte-related genes and that they are implicated in the schizophrenia pathology. We found that RXR agonist bexarotene increased the expression levels of the oligodendrocyte-related genes and that the RXR antagonist HX531 decreased them in the OLP6 cells (the oligodendrocyte cell line). The RXR agonist bexarotene also elicited a trend toward increased expression of those genes in wild type mice. Treatment of mice with bexarotene tended to suppress the hyper-locomotive responses induced by MK-801. Notably, expressions of the nuclear receptor genes were found to be down-regulated in hair follicles cells from individuals affected with schizophrenia. Taken together, these results suggest that the RXR system regulates oligodendrocyte-related genes, thereby playing a crucial role in the schizophrenia pathophysiology.
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