Pathology of schizophrenia by regulation of oligodendrocyte related-genes
Project/Area Number |
15K09814
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Maekawa Motoko 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (50435731)
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Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA Takeo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30249958)
OHNISHI Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (80373281)
TOYOSHIMA Manabu 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90582750)
SHIMAMOTO Chie 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (90755117)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | オリゴデンドロサイト / RXR / 統合失調症 / 核内受容体 |
Outline of Final Research Achievements |
We hypothesized that specific nuclear receptors regulate expressions of multiple oligodendrocyte-related genes and that they are implicated in the schizophrenia pathology. We found that RXR agonist bexarotene increased the expression levels of the oligodendrocyte-related genes and that the RXR antagonist HX531 decreased them in the OLP6 cells (the oligodendrocyte cell line). The RXR agonist bexarotene also elicited a trend toward increased expression of those genes in wild type mice. Treatment of mice with bexarotene tended to suppress the hyper-locomotive responses induced by MK-801. Notably, expressions of the nuclear receptor genes were found to be down-regulated in hair follicles cells from individuals affected with schizophrenia. Taken together, these results suggest that the RXR system regulates oligodendrocyte-related genes, thereby playing a crucial role in the schizophrenia pathophysiology.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.2017
Author(s)
Balan S, Yamada K, Iwayama Y, Hashimoto T, Toyota T, Shimamoto C, Maekawa M, Takagai S, Wakuda T, Kameno Y, Kurita D, Yamada K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T
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Journal Title
Schizophrenia Research
Volume: 印刷中
Pages: 33-40
DOI
Related Report
Peer Reviewed
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[Journal Article] Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons.2016
Author(s)
Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y.
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Journal Title
Glia
Volume: 64(1)
Issue: 1
Pages: 48-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genome-wide Association Study of Autism Spectrum Disorder in the East Asian Populations.2016
Author(s)
2. Liu X, Shimada T, Otowa T, Wu YY, Kawamura Y, Tochigi M, Iwata Y, Umekage T, Toyota T, Maekawa M, Iwayama Y, Suzuki K, Kakiuchi C, Kuwabara H, Kano Y, Nishida H, Sugiyama T, Kato N, Chen CH, Mori N, Yamada K, Yoshikawa T, Kasai K, Tokunaga K, Sasaki T, Gau SS.
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Journal Title
Autism Res.
Volume: 9
Issue: 3
Pages: 340-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.2015
Author(s)
Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T
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Journal Title
Sci Rep.
Volume: 5
Issue: 1
Pages: 16239-16239
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1.2015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
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Journal Title
Glia
Volume: 63
Issue: 5
Pages: 780-794
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 質量分析法を用いた統合失調症関連脂質の探索2017
Author(s)
島本知英, 大西哲生, 江崎加代子, 前川素子, 渡辺明子, 豊島学, 杉山栄二, 大和田祐二, 瀬藤光利, 吉川武男
Organizer
第12回日本統合失調症学
Place of Presentation
米子コンベンションセンターBIG SHIP(鳥取)
Year and Date
2017-03-24
Related Report
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[Presentation] Polyunsaturated fatty acid deficiency during early neurodevelopmental stages can cause vulnerability to psychosis, through epigenetic changes in nuclear receptor genes2017
Author(s)
Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iyamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T
Organizer
第40回日本神経科学大会
Related Report
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