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Molecular mechanism regulating circadian rhythms and mood

Research Project

Project/Area Number 15K09817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Hida Akiko  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 室長 (20333354)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords生物時計 / 睡眠障害 / 概日リズム / 培養細胞 / リポーター遺伝子 / 遺伝子
Outline of Final Research Achievements

We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep-wake disorders (CRSWDs) by measuring Bmal1-luciferase (Bmal1-luc) rhythms in fibroblast cells derived from individual patients (in vitro rhythms). The period length of the Bmal1-luc rhythm (in vitro period) varied among individuals.The N24SWD group showed a significantly longer in vitro period than did the control or DSWPD group. Furthermore, in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders compared to the responders in the N24SWD group. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSWDs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders2017

    • Author(s)
      A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
    • Journal Title

      Transl Psychiatry

      Volume: 7 Issue: 4 Pages: e1106-e1106

    • DOI

      10.1038/tp.2017.75

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 生体リズムと女性2017

    • Author(s)
      肥田昌子
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 概日リズム睡眠覚醒障害の遺伝要因の探索2017

    • Author(s)
      肥田昌子
    • Organizer
      第24回日本時間生物学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pathophysiology of Circadian Rhythm Sleep-Wake Disorders2017

    • Author(s)
      Akiko Hida
    • Organizer
      The 6th Annual IIIS Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Mental and physical disorders attributable to desynchronization between social time requirements and an individuals sleep-wake rhythm2017

    • Author(s)
      Akiko Hida
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Benefits and Mysteries of Sleep2017

    • Author(s)
      Akiko Hida
    • Organizer
      Japanese-American-German Frontiers of Science Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 概日リズム睡眠障害の治療反応性と末梢時計リズム周期2017

    • Author(s)
      1.肥田昌子, 北村真吾, 中﨑恭子, 綾部直子, 元村祐貴, 加藤美恵, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 草薙宏明, 亀井雄一, 三島和夫
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 概日リズム睡眠障害の病態生理と治療反応性2016

    • Author(s)
      肥田昌子
    • Organizer
      第23回日本時間生物学会学術大会
    • Place of Presentation
      愛知、名古屋大学豊田講堂
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 睡眠相後退型、フリーラン型の抹消時計リズム周期2016

    • Author(s)
      肥田昌子, 北村真吾, 中﨑恭子, 綾部直子, 元村祐貴, 加藤美恵, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 草薙宏明, 亀井雄一, 三島和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Association study of circadian genes in a Japanese population2015

    • Author(s)
      肥田昌子、北村真吾、片寄泰子、加藤美恵、小野浩子、角谷 寛、内山 真、海老澤尚、井上雄一、亀井雄一、大川匡子、高橋清久、三島和夫
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京、伊藤国際学術研究センター
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 日本人集団における概日リズム睡眠障害の多型解析2015

    • Author(s)
      肥田昌子, 北村真吾, 片寄泰子, 加藤美恵, 小野浩子, 角谷寛, 内山真, 海老沢尚, 井上雄一, 亀井雄一, 大川匡子, 高橋清久, 三島和夫
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      東京、タワーホール船堀
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 概日リズム障害とPER3反復配列・OPN4多型の関連解析2015

    • Author(s)
      肥田昌子, 北村真吾, 片寄泰子, 加藤美恵, 小野浩子, 角谷寛, 内山真, 海老沢尚, 井上雄一, 亀井雄一, 大川匡子, 高橋清久, 三島和夫
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      栃木、栃木県総合文化センター
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Book] 睡眠科学 15章 睡眠と体内時計を測る2016

    • Author(s)
      肥田昌子
    • Total Pages
      12
    • Publisher
      化学同人
    • Related Report
      2016 Research-status Report
  • [Remarks] 皮膚細胞を用いて『概日リズム睡眠-覚醒障害患者』の 体内時計周期の異常を同定

    • URL

      https://www.ncnp.go.jp/press/release.html?no=344

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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