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Research of pathological conditions of sleep and psychiatric disorders caused by autoantibodies (AQP4, NMDAR)

Research Project

Project/Area Number 15K09821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionAkita University

Principal Investigator

Shimizu Tetsuo  秋田大学, 医学(系)研究科(研究院), 教授 (90170977)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオレキシン / 抗NMDA受容体抗体 / 症候性過眠症 / 統合失調症 / NMO / AQP4 / orexin / narcolepsy / NMDA encephalitis / schizophrenia / 過眠症 / NMDA受容体脳炎 / NMDA
Outline of Final Research Achievements

(1) Impaired orexin nervous system has been reported in NMO, the self-antibody of AQP4 and MOG were found. We investigated AQP4, MOG antibodies and orexin. In 33 NMO cases, 25 of AQP4 positive cases and 2 of MOG positive cases.
(2) With the anti-NMDA receptor antibodies, examinations were limited the cases of CSF. We founded 14 positive cases in 169 cases derived from psychiatry. Seven cases of 14 cases was a case that led to encephalitis, initially it had been diagnosed with catatonia. The other seven cases are only cases of psychiatric symptoms without neurological symptoms. In addition, we found a positive example of four cases from 20 sleep disorder cases. Among the positive examples of four cases of sleep disorder, three cases were narcolepsy. In the case of psychiatric symptoms with no neurological symptoms, a detailed analysis is being continued.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (65 results)

All 2018 2017 2016 2015

All Journal Article (39 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 24 results,  Open Access: 9 results) Presentation (24 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness.2018

    • Author(s)
      Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K, Uemura S, Shimizu T.
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 14 Pages: 451-457

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Experience with a Dual Orexin Receptor Antagonist, Suvorexant (Belsomra) in Japan.2018

    • Author(s)
      Ono H, Kanbayashi T, Iwaki S, Takahashi J, Imanishi A, Sagawa Y, Tsutsui K, Omori Y, Nishino S, Shimizu T.
    • Journal Title

      J Sleep Disord Med Care

      Volume: 1(1)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation2018

    • Author(s)
      Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M, Nishino S, Shimizu T.
    • Journal Title

      Neuropsychiatr Dis Treat in press

      Volume: ー

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy2018

    • Author(s)
      Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M.
    • Journal Title

      PNSA in press

      Volume: ー

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythaematosus patients presenting with excessive daytime sleepiness2018

    • Author(s)
      Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
    • Journal Title

      Lupus in press

      Volume: ー

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-Methyl-D-aspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection.2017

    • Author(s)
      Tsutsui K, Kanbayashi T, Takaki M, Omori Y, Imai Y, Nishino S, Tanaka K, Shimizu T.
    • Journal Title

      Neuropsychiatric Dis Treat.

      Volume: 13 Pages: 339-345

    • DOI

      10.2147/ndt.s125800

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study2017

    • Author(s)
      Takahashi Jun、Kanbayashi Takashi、Ito Uemura Sachiko、Sagawa Youhei、Tsutsui Kou、Takahashi Yuya、Omori Yuki、Imanishi Aya、Takeshima Masahiro、Satake Masahiro、Shimizu Tetsuo
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 15 Issue: 3 Pages: 235-241

    • DOI

      10.1007/s41105-017-0101-2

    • NAID

      40021252525

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Precarious Employment Is Not Associated with Increased Depressive Symptoms: A Cross-Sectional Study in Care Service Workers of Japan2017

    • Author(s)
      Tanaka O, Maeda E, Fushimi M, Iwata T, Shimizu T, Saito S, Murata K.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 243 Issue: 1 Pages: 19-26

    • DOI

      10.1620/tjem.243.19

    • NAID

      130006070154

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Residual effects of eszopiclone on daytime alertness, psychomotor, physical performance and subjective evaluations2017

    • Author(s)
      Suda H, Ito SU, Sagawa Y, Imanishi A, Tsutsui K, Takahashi J, Kikuchi Y, Takahashi Y, Shimizu T.
    • Journal Title

      Sleep Biol Rhythms

      Volume: 15(4) Pages: 311-16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute effects of zaleplon on daytime functions on the following day: psychomotor and physical performances, arousal levels and mood2017

    • Author(s)
      ITO W, KANBAYASHI T, SHIMIZU K, UEMURA SI, WAKASA M, INOUE Y, SHIMIZU T, NISHINO S
    • Journal Title

      Gazzetta Medica Italiana Archivio per le Scienze Mediche

      Volume: 176(5) Pages: 257-64

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抑うつ症状を伴う睡眠相後退症候群に対するaripiprazoleの有効性の単群試験による検討2017

    • Author(s)
      大森 佑貴, 神林 崇, 高木 学, 筒井 幸, 高橋 裕哉, 佐川 洋平, 今西 彩, 高橋 淳, 小野 太輔, 清水 徹男
    • Journal Title

      精神科治療学

      Volume: 32(6) Pages: 831-834

    • NAID

      40021246081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【精神医学症候群(第2版)-不安症から秩序破壊的・衝動制御・素行症まで-】 睡眠-覚醒障害群 ナルコレプシー2017

    • Author(s)
      大森 佑貴, 今西 彩, 竹越 結生, 神林 崇, 清水 徹男
    • Journal Title

      日本臨床別冊

      Volume: ー Pages: 367-373

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【分子精神医学の最前線】2017

    • Author(s)
      小野 太輔, 神林 崇, 佐川 洋平, 今西 彩, 清水 徹男
    • Journal Title

      オレキシン精神科

      Volume: 30(1) Pages: 68-74

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute Respiratory Distress Syndrome and Lamotrigine.2016

    • Author(s)
      Takeshima M, Ishikawa H, Shimizu T.
    • Journal Title

      Psychosomatics

      Volume: S0033-3182(16) Issue: 3 Pages: 30173-6

    • DOI

      10.1016/j.psym.2016.12.005

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome.2016

    • Author(s)
      Mayu Omokawa, Tadayuki Ayabe, Toshiro Nagai, Aya Imanishi, Ayumi Omokawa, Seiji Nishino, Yohei Sagawa, Tetsuo Shimizu, Takashi Kanbayashi.
    • Journal Title

      American Journal of Medical Genetics part A

      Volume: 170 Issue: 5 Pages: 1181-1186

    • DOI

      10.1002/ajmg.a.37542

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with or without midbrain involvement.2016

    • Author(s)
      Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95(29) Issue: 29 Pages: e4281-e4281

    • DOI

      10.1097/md.0000000000004281

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of painful physical symptoms in the treatment of Japanese patients with melancholic major depressive disorder.2016

    • Author(s)
      Sekine A, Hozumi S, Shimizu T.
    • Journal Title

      Psychiatry Res

      Volume: 242 Pages: 240-4

    • DOI

      10.1016/j.psychres.2016.05.053

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decline of CSF orexin (hypocretin) levels in Prader-Willi syndrome.2016

    • Author(s)
      Omokawa M, Ayabe T, Nagai T, Imanishi A, Omokawa A, Nishino S, Sagawa Y, Shimizu T, Kanbayashi T.
    • Journal Title

      Am J Med Genet A.

      Volume: 170(5) Issue: 5 Pages: 1181-6

    • DOI

      10.1016/j.psym.2016.02.009

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] NEUROPSYCHOLOGICAL CORRELATES OF REGIONAL CEREBRAL BLOOD FLOW IN ALZHEIMER'S DISEASE USING CORRELATION IMAGING PLOTS.2016

    • Author(s)
      Takano D, Yamazaki T, Nagata K, Kanbayashi T, Shimizu T.
    • Journal Title

      秋田医学

      Volume: 43(2) Pages: 65-78

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 精神症状を呈した再発性多発軟骨炎の1例.2016

    • Author(s)
      大森 佑貴, 草薙 宏明, 筒井 幸, 高橋 淳, 安宅 慶一郎, 奈良 瑞穂, 利川 嘉明, 大谷 隆浩, 高橋 聡, 齋藤 英知, 神林 崇, 清水 徹男
    • Journal Title

      精神科治療学

      Volume: 31(2) Pages: 247-253

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【[改訂版]精神科・わたしの診療手順】(第13章)睡眠-覚醒障害群 レム睡眠行動障害.2016

    • Author(s)
      清水 徹男
    • Journal Title

      臨床精神医学

      Volume: 45supl Pages: 354-356

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【[改訂版]精神科・わたしの診療手順】(第13章)睡眠-覚醒障害群 悪夢障害.2016

    • Author(s)
      竹島 正浩,清水 徹男
    • Journal Title

      臨床精神医学

      Volume: 45supl Pages: 351-353

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【検査施設外睡眠検査(OCST)の現状と適正使用】 日本睡眠学会エキスパートコンセンサスの概要 作成の経緯とその役割.2016

    • Author(s)
      清水 徹男
    • Journal Title

      睡眠医療

      Volume: 10(4) Pages: 571-576

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【糖尿病・うつ・睡眠障害による負のトライアングル】 睡眠障害・うつの糖尿病・身体疾患に及ぼす影響 うつの影響メカニズム.2016

    • Author(s)
      清水 徹男
    • Journal Title

      月刊糖尿病

      Volume: 8(11) Pages: 82-87

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【統合失調症のベストプラクティス】 (第II部)各論 身体管理と副作用対策 抗精神病薬による脳波異常,けいれん発作.2016

    • Author(s)
      菊池 結花,清水 徹男
    • Journal Title

      精神科治療学

      Volume: 31supl Pages: 173-175

    • Related Report
      2016 Research-status Report
  • [Journal Article] 臨床医が実践できる診療ワンポイント(第5回) 睡眠薬使用のワンポイント.2016

    • Author(s)
      清水 徹男
    • Journal Title

      ねむりとマネージメント

      Volume: 3(2) Pages: 83-85

    • NAID

      40020969465

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【従来型向精神薬再考-従来型薬が使われるのはどのような場合か-】 ニトラゼパム.2016

    • Author(s)
      竹島 正浩,清水 徹男
    • Journal Title

      精神科治療学

      Volume: 29(3) Pages: 202-206

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【認知機能とアンチエイジング】 睡眠と認知機能アンチエイジング.2016

    • Author(s)
      清水 徹男
    • Journal Title

      アンチ・エイジング医学

      Volume: 12(4) Pages: 346-350

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【不眠治療の現状と対策】 非ベンゾジアゼピン系睡眠薬の効果的な使用法と副作用.2016

    • Author(s)
      清水 徹男
    • Journal Title

      臨床精神薬理

      Volume: 19(1) Pages: 69-76

    • Related Report
      2016 Research-status Report
  • [Journal Article] 睡眠障害と関連した心・身疾患の豆知識(第8回) 中枢性過眠症と神経免疫疾患 脱髄性疾患および抗AQP4抗体,抗Ma2抗体,抗NMDA受容体抗体による脳症.2016

    • Author(s)
      今西 彩,神林 崇,久保田 弘樹,筒井 幸,佐川 洋平,竹島 正浩,大森 佑貴,高橋 裕哉,小野 太輔,清水 徹男
    • Journal Title

      睡眠医療

      Volume: 10(4) Pages: 591-597

    • NAID

      40021051244

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【分子精神医学の最前線】 オレキシン.2016

    • Author(s)
      小野 太輔,神林 崇,佐川 洋平,今西 彩,清水 徹男
    • Journal Title

      精神科

      Volume: 30(1) Pages: 68-74

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【統合失調症のベストプラクティス】 (第II部)各論 統合失調症との類縁/鑑別病態再検討 統合失調症と抗NMDA受容体脳炎との鑑別.2016

    • Author(s)
      筒井 幸,神林 崇,田中 惠子,清水 徹男
    • Journal Title

      精神科治療学

      Volume: 31supl Pages: 377-380

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【睡眠障害と臨床検査】 過眠症の基礎と検査.2016

    • Author(s)
      大森 佑貴,神林 崇,今西 彩,山田 康子,清水 徹男
    • Journal Title

      臨床検査

      Volume: 60(9) Pages: 940-945

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【抗NMDA受容体脳炎】 抗NMDA受容体脳炎の概念.2016

    • Author(s)
      筒井 幸,神林 崇,田中 惠子,清水 徹男
    • Journal Title

      精神科

      Volume: 28(6) Pages: 488-491

    • Related Report
      2016 Research-status Report
  • [Journal Article] tandby guardianship 患者の自己決定に基づく親権代行2016

    • Author(s)
      石川 博康,猪股 良之,神林 崇,清水 徹男
    • Journal Title

      精神医学

      Volume: 58(1) Pages: 87-94

    • Related Report
      2016 Research-status Report
  • [Journal Article] Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review.2015

    • Author(s)
      Suzuki K, Kawasaki A, Miyamoto M, Miyamoto T, Kanbayashi T, Sato M, Shimizu T, Hirata K.
    • Journal Title

      Medicine (Baltimore)

      Volume: 94(25) Issue: 25 Pages: e1065-e1065

    • DOI

      10.1097/md.0000000000001065

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship of orexin(hypocretin) system and astrocyte activation in Parkinson's disease with hypersomnolence2015

    • Author(s)
      Takahashi Yuya, Kanbayashi Takashi, Hoshikawa Masamitsu, Imanishi Aya, Sagawa Yohei, Tsutsui Kou, Takeda Yasuhiro, K usanagi Hiroaki, Nishino Seiji, Shimizu Tetsuo
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 13(3) Pages: 252-260

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Apnea during Cheyne-Stokes-like breathing detected by a piezoelectric sensor for screening of sleep disordered breathing2015

    • Author(s)
      Koyama Takashi, Sato Shinichi, Kanbayashi Takashi, Kondo Hideaki, Watanabe Hiroyuki, Nishino Seiji, Shimizu Tetsuo, Ito Hiroshi, Ono Kyoichi
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 13(1) Pages: 57-67

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.2015

    • Author(s)
      Miyagawa T, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.
    • Journal Title

      Hum Genome Var.

      Volume: 17(2) Issue: 1 Pages: 15031-15031

    • DOI

      10.1038/hgv.2015.31

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 眠りと健康2017

    • Author(s)
      清水徹男
    • Organizer
      日本デイケア学会第22回年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] レム睡眠の解離現象と睡眠ポリグラム2016

    • Author(s)
      清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Orexin受容体拮抗薬Suvorexantの使用経験(第2報) せん妄も含めて.2016

    • Author(s)
      小野 宏晃,高橋 淳,岩城 忍,今西 彩,佐川 洋平,木村 景,橋本 誠,小野 太輔,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗Ma2抗体陽性であった症候性ナルコレプシー患者の1例2016

    • Author(s)
      今西 彩,成田 恵理子,池田 祐介,山辺 拓也,西田 晶子,大森 佑貴,平野 梨聖,倉澤 悠紀,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] ナルコレプシーの情動脱力発作とその他のレム関連症状に対する5種の薬剤による治療の検討 最新のベンラファキシンも含めて(第2報)2016

    • Author(s)
      今西 彩,大森 佑貴,小野 太輔,高橋 淳,野澤 成大,小野 宏晃,佐川 洋平,筒井 幸,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス睡眠覚醒移行期の非侵襲的心拍呼吸活動記録2016

    • Author(s)
      佐藤 紳一,神林 崇,今西 彩,小野 宏晃,筒井 幸,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 体温と簡易脳波から見た硫黄泉の睡眠への効果.2016

    • Author(s)
      上村 佐知子,梶原 紗希,大貫 周悟,高橋 淳,神林 崇,佐竹 將宏,塩谷 隆信,清水 徹男,西野 精治(
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Neuromyelitis optica spectrum disorderの抗MOG抗体とオレキシン値の検討.2016

    • Author(s)
      久保田 弘樹,今西 彩,矢野 珠巨,佐川 洋平,筒井 幸,小野 太輔,野澤 成大,神林 崇,高橋 勉,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 抑うつ症状を伴う睡眠相後退症候群に対するアリピプラゾールの有効性の検討:第2報.2016

    • Author(s)
      大森 佑貴,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,今西 彩,高橋 淳,小野 太輔,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 過眠症状を伴う筋強直性ジストロフィーにおける脳脊髄液中オレキシン値の検討2016

    • Author(s)
      大森 佑貴,今西 彩,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,高橋 淳,小野 太輔,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 無呼吸信号のFFT解析および心周期変動解析による呼吸努力の定量的解析2016

    • Author(s)
      佐藤 紳一,西島 嗣生,遠藤 文代,神林 崇,山内 基夫,山城 義広,清水 徹男,櫻井 滋
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠から見たうつ病の病態と治療 うつ病相における過眠症状 夜間睡眠の延長と日中の過度の眠気2016

    • Author(s)
      神林 崇,今西 彩,鈴木 りほ,池田 祐介,平野 梨聖,竹越 結生,佐々木 諒,藤原 大,佐藤 優真,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠障害と精神疾患の病態・治療上の接点 過眠症(i:夜間睡眠の延長、ii:日中の眠気)の治療薬.2016

    • Author(s)
      神林 崇,今西 彩,小野 太輔,佐川 洋平,野澤 成大,小野 宏晃,大森 佑貴,高橋 淳,高橋 裕哉,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] A QUANTITATIVE METHOD FOR RESPIRATORY-EFFORT DETECTION BY POWER-SPECTRAL DENSITY ANALYSIS OF ON-MATTRESS PIEZOELECTRIC-SENSOR SIGNAL.2016

    • Author(s)
      Sato S, Nishijima T, Endou F, Kanbayashi T, Yamauchi M, Yamashiro Y, Shimizu T, Sakurai S.
    • Organizer
      The Annual Meeting of the Associated Professional Sleep Societies2016
    • Place of Presentation
      デンバー
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] SEVERAL COMPARATIVE TREATMENTS FOR REM RELATED SYMPTOMS AND NOCTURNAL SLEEP DISTURBANCES OF NARCOLEPTIC PATIENT.2016

    • Author(s)
      Imanishi A, Ohmori Y, Suzuki R, Kato N, Sagawa Y, Takahashi Y, Takahashi J, Tsutsui K, Kanbayashi T, Shimizu T.
    • Organizer
      The Annual Meeting of the Associated Professional Sleep Societies2016
    • Place of Presentation
      デンバー
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗Ma2抗体陽性であった症候性ナルコレプシーの1例.2016

    • Author(s)
      成田 恵理子,今西 彩,池田 祐介,川辺 拓也,大森 佑貴,筒井 幸,佐川 洋平,高橋 淳,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] カタレプシーを呈した急性デキストロメトルファン中毒の一例.2016

    • Author(s)
      高橋 淳,大森 佑貴,竹島 正浩,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠相後退症候群と抑うつ症状の併存例へのアリピプラゾールの有効性.2016

    • Author(s)
      大森 佑貴,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,今西 彩,高橋 淳,佐藤 優真,佐々木 諒,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 精神症状を来す自己免疫性脳症 精神科領域における抗NMDA受容体抗体陽性例.2016

    • Author(s)
      筒井 幸,大森 佑貴,森 朱音,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Symptomatic Narcolepsy among Children and Adolescence, Such as Niemann-Pick Type C and Prader-Willi Syndrome2016

    • Author(s)
      Takashi Kanbayashi, Tetsuo Shimizu
    • Organizer
      The 4th International Pediatric Sleep Association Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-03-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] INTERMEDIATE DECLINE OF CEREBROSPINAL FLUID OREXIN (HYPOCRETIN) LEVEL AND SIGNIFICANT OBESITY IN PRADER - WILLI SYNDROME PAT IENTS COMPARED WITH NARCOLEPSY AND IDIOPATHIC HYPERSOMNIA2015

    • Author(s)
      Omokawa M1, Ayabe T2, Kanbayashi T1,3, Imanishi A1, Omori Y1, Tsutsui K1, Takahashi J1, Takahashi Y1, Kikuchi Y1, Narita E1, Sato M 4, Kubota H 5, Noguchi A 5, Takahashi T 5, Shimizu T
    • Organizer
      A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] THE CORRELATION OF OREXIN (HYPOCRETIN) SYSTEM AND ASTROCYTE ACTIVATION IN PARKINSON’S DISEASE WITH HYPERSOMNOLENCE2015

    • Author(s)
      Takahash i Y1, Kanbayashi T1,2, Hoshikawa M3, Yamamoto J3, Imanishi A1, Sagawa Y1, Tsutsui K1, Tsukamoto K4, Takeda Y3, Shimizu T1,2
    • Organizer
      A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Imanishi A1, Kawazoe T2, Hamada Y3, Ohmori Y1, Omokawa M1, Sagawa Y1, Takahashi Y1, Takahashi J1, Tsutsui K1, Kanbayashi T1, 4, Sakai N3, Shimizu T1,42015

    • Author(s)
      CEREBROFSPINAL FLUID OREXIN LEVELS IN SYMPTOMATIC NARCOLEPSY - CATAPLEXY, NIEMANN-PICKTYPE C
    • Organizer
      A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] CSF OREXIN LEVELS IN HYPERSOMNIA FOLLOWING HPV VACCINATION2015

    • Author(s)
      Sagawa Y1, Imanishi A1, Omori Y1, Omokawa M1, Taniguchi T2, Usumoto A2, Yuge K3, Kotorii N4, Kinoshita T5, Hirai T6, Narita E1, Narumi Takeshima A7, Shiota M7, Kanbayashi T1, Shimizu T1 1
    • Organizer
      A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency Narcolepsy, 2nd Edition: A Clinical Guide2016

    • Author(s)
      Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, and Nishino S.
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] Chapter 9, Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency, Narcolepsy A Clinical Guide Second Edition2016

    • Author(s)
      Takashi Kanbayashi, Aya Imanishi, Yuki Ohmori, Yohei Sagawa, Yuya Takahashi, Mayu Omokawa, Masatoshi Sato, Yasuo Hishikawa, Tetsuo Shimizu, and Seiji Nishino
    • Total Pages
      33
    • Publisher
      Springer International Publishing Switzerland
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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