Research of pathological conditions of sleep and psychiatric disorders caused by autoantibodies (AQP4, NMDAR)
| Project/Area Number |
15K09821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
Shimizu Tetsuo 秋田大学, 医学(系)研究科(研究院), 教授 (90170977)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | オレキシン / 抗NMDA受容体抗体 / 症候性過眠症 / 統合失調症 / NMO / AQP4 / orexin / narcolepsy / NMDA encephalitis / schizophrenia / 過眠症 / NMDA受容体脳炎 / NMDA |
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| Outline of Final Research Achievements |
(1) Impaired orexin nervous system has been reported in NMO, the self-antibody of AQP4 and MOG were found. We investigated AQP4, MOG antibodies and orexin. In 33 NMO cases, 25 of AQP4 positive cases and 2 of MOG positive cases.
(2) With the anti-NMDA receptor antibodies, examinations were limited the cases of CSF. We founded 14 positive cases in 169 cases derived from psychiatry. Seven cases of 14 cases was a case that led to encephalitis, initially it had been diagnosed with catatonia. The other seven cases are only cases of psychiatric symptoms without neurological symptoms. In addition, we found a positive example of four cases from 20 sleep disorder cases. Among the positive examples of four cases of sleep disorder, three cases were narcolepsy. In the case of psychiatric symptoms with no neurological symptoms, a detailed analysis is being continued.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Clinical Experience with a Dual Orexin Receptor Antagonist, Suvorexant (Belsomra) in Japan.2018
Author(s)
Ono H, Kanbayashi T, Iwaki S, Takahashi J, Imanishi A, Sagawa Y, Tsutsui K, Omori Y, Nishino S, Shimizu T.
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Journal Title
J Sleep Disord Med Care
Volume: 1(1)
Related Report
Peer Reviewed
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[Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythaematosus patients presenting with excessive daytime sleepiness2018
Author(s)
Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Residual effects of eszopiclone on daytime alertness, psychomotor, physical performance and subjective evaluations2017
Author(s)
Suda H, Ito SU, Sagawa Y, Imanishi A, Tsutsui K, Takahashi J, Kikuchi Y, Takahashi Y, Shimizu T.
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Journal Title
Sleep Biol Rhythms
Volume: 15(4)
Pages: 311-16
Related Report
Peer Reviewed
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[Journal Article] 精神症状を呈した再発性多発軟骨炎の1例．2016
Author(s)
大森 佑貴, 草薙 宏明, 筒井 幸, 高橋 淳, 安宅 慶一郎, 奈良 瑞穂, 利川 嘉明, 大谷 隆浩, 高橋 聡, 齋藤 英知, 神林 崇, 清水 徹男
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Journal Title
精神科治療学
Volume: 31(2)
Pages: 247-253
Related Report
Peer Reviewed
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[Journal Article] An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.2015
Author(s)
Miyagawa T, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.
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Journal Title
Hum Genome Var.
Volume: 17(2)
Issue: 1
Pages: 15031-15031
DOI
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Peer Reviewed / Open Access
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[Presentation] INTERMEDIATE DECLINE OF CEREBROSPINAL FLUID OREXIN (HYPOCRETIN) LEVEL AND SIGNIFICANT OBESITY IN PRADER - WILLI SYNDROME PAT IENTS COMPARED WITH NARCOLEPSY AND IDIOPATHIC HYPERSOMNIA2015
Author(s)
Omokawa M1, Ayabe T2, Kanbayashi T1,3, Imanishi A1, Omori Y1, Tsutsui K1, Takahashi J1, Takahashi Y1, Kikuchi Y1, Narita E1, Sato M 4, Kubota H 5, Noguchi A 5, Takahashi T 5, Shimizu T
Organizer
A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
Place of Presentation
Seattle, USA
Year and Date
2015-06-10
Related Report
Int'l Joint Research
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[Presentation] THE CORRELATION OF OREXIN (HYPOCRETIN) SYSTEM AND ASTROCYTE ACTIVATION IN PARKINSON’S DISEASE WITH HYPERSOMNOLENCE2015
Author(s)
Takahash i Y1, Kanbayashi T1,2, Hoshikawa M3, Yamamoto J3, Imanishi A1, Sagawa Y1, Tsutsui K1, Tsukamoto K4, Takeda Y3, Shimizu T1,2
Organizer
A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
Place of Presentation
Seattle, USA
Year and Date
2015-06-10
Related Report
Int'l Joint Research
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[Presentation] Imanishi A1, Kawazoe T2, Hamada Y3, Ohmori Y1, Omokawa M1, Sagawa Y1, Takahashi Y1, Takahashi J1, Tsutsui K1, Kanbayashi T1, 4, Sakai N3, Shimizu T1,42015
Author(s)
CEREBROFSPINAL FLUID OREXIN LEVELS IN SYMPTOMATIC NARCOLEPSY - CATAPLEXY, NIEMANN-PICKTYPE C
Organizer
A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
Place of Presentation
Seattle, USA
Year and Date
2015-06-10
Related Report
Int'l Joint Research
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[Presentation] CSF OREXIN LEVELS IN HYPERSOMNIA FOLLOWING HPV VACCINATION2015
Author(s)
Sagawa Y1, Imanishi A1, Omori Y1, Omokawa M1, Taniguchi T2, Usumoto A2, Yuge K3, Kotorii N4, Kinoshita T5, Hirai T6, Narita E1, Narumi Takeshima A7, Shiota M7, Kanbayashi T1, Shimizu T1 1
Organizer
A joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society
Place of Presentation
Seattle, USA
Year and Date
2015-06-10
Related Report
Int'l Joint Research
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[Book] Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency Narcolepsy, 2nd Edition: A Clinical Guide2016
Author(s)
Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, and Nishino S.
Publisher
Springer
Related Report
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[Book] Chapter 9, Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency, Narcolepsy A Clinical Guide Second Edition2016
Author(s)
Takashi Kanbayashi, Aya Imanishi, Yuki Ohmori, Yohei Sagawa, Yuya Takahashi, Mayu Omokawa, Masatoshi Sato, Yasuo Hishikawa, Tetsuo Shimizu, and Seiji Nishino
Total Pages
33
Publisher
Springer International Publishing Switzerland
Related Report
