Protective and risk factors associated with progressive brain alterations in schizophrenia

• Project/Area Number: 15K09825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: Sugihara Genichi 京都大学, 医学研究科, 助教 (70402261)
• Co-Investigator(Kenkyū-buntansha): 吉原 雄二郎 京都大学, 医学研究科, 特定助教 (00529464) ; 大石 直也 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878) ; 生方 志浦 京都大学, 医学研究科, 研究員 (40738960)
• Research Collaborator: NAKAGAMI Yukako ; YOKOYAMA Naoto
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症 / 脳画像

Outline of Final Research Achievements

Schizophrenia is a mental disorder which has been linked to subtle brain structural abnormalities. However, such brain abnormalities in schizophrenia vary from person to person. We explored factors which could be associated with individual differences of brain abnormalities in schizophrenia. We found that structural brain abnormalities linked to higher dose of antipsychotic medication, smoking status, and severity of clinical symptoms. We also investigated relationships between autoimmune factors and schizophrenia, but we did not find individuals with schizophrenia who had a specific autoantibody in our sample. Further research is warranted to identify factors which may have protective effects on schizophrenia brains.

Research Products

• [Journal Article] Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial. (2018)
  • Author(s): Nakagami Y, Kubo H, Katsuki R, Sakai T, Sugihara G, Naito C, Oda H, Hayakawa K, Suzuki Y, Fujisawa D, Hashimoto N, Kobara K, Cho T, Kuga H, Takao K, Kawahara Y, Matsumura Y, Murai T, Akashi K, Kanba S, Otsuka K, Kato TA
  • Journal Title: Journal of Affective Disorders Volume: 225 Pages: 569-576
  • DOI: 10.1016/j.jad.2017.08.074
  • Peer Reviewed
• [Journal Article] Is the prevalence of anti-N-methyl-d-aspartate receptor antibodies in schizophrenia overestimated? (2017)
  • Author(s): Nakagami Y, Sugihara G, Ikeda A, Murai T.
  • Journal Title: Schizophr Res. Volume: S0920-9964 Pages: 30759-4
  • DOI: 10.1016/j.schres.2017.12.007
  • Peer Reviewed
• [Journal Article] Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia (2017)
  • Author(s): Yokoyama Naoto、Sasaki Hitoshi、Mori Yasuo、Ono Miki、Tsurumi Kousuke、Kawada Ryosaku、Matsumoto Yukiko、Yoshihara Yujiro、Sugihara Genichi、Miyata Jun、Murai Toshiya、Takahashi Hidehiko
  • Journal Title: Schizophr Bull. Volume: 1 Pages: 1-10
  • DOI: 10.1093/schbul/sbx092
  • Peer Reviewed / Open Access
• [Journal Article] Self-efficacy modulates the neural correlates of craving in male smokers and ex-smokers: an fMRI study (2017)
  • Author(s): Ono Miki、Kochiyama Takanori、Fujino Junya、Sozu Takashi、Kawada Ryosaku、Yokoyama Naoto、Sugihara Genichi、Murai Toshiya、Takahashi Hidehiko
  • Journal Title: Addict Biol. Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1111/adb.12555
  • Peer Reviewed / Open Access
• [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia. (2017)
  • Author(s): Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
  • Journal Title: Social Neuroscience Volume: Aug 25 Issue: 5 Pages: 1-8
  • DOI: 10.1080/17470919.2017.1366363
  • Peer Reviewed / Open Access
• [Journal Article] Common and differential brain abnormalities in gambling disorder subtypes based on risk attitude. (2017)
  • Author(s): Takeuchi H, Tsurumi K, Murao T, Takemura A, Kawada R, Urayama SI, Aso T,Sugihara GI, Miyata J, Murai T, Takahashi H.
  • Journal Title: Addictive Behaviors Volume: 69 Pages: 48-54
  • DOI: 10.1016/j.addbeh.2017.01.025
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach. (2016)
  • Author(s): Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T.
  • Journal Title: Schizophr Bull. Volume: - Pages: 900-906
  • DOI: 10.1093/schbul/sbw176
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Corpus Callosum Pathology as a Potential Surrogate Marker of Cognitive Impairment in Diffuse Axonal Injury. (2015)
  • Author(s): Ubukata S, Ueda K, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T.
  • Journal Title: J Neuropsychiatry Clin Neurosci. Volume: 28 Issue: 2 Pages: 97-103
  • DOI: 10.1176/appi.neuropsych.15070159
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia. (2015)
  • Author(s): Uwatoko T, Yoshizumi M, Miyata J, Ubukata S, Fujiwara H, Kawada R, Kubota M, Sasamoto A, Sugihara G, Aso T, Urayama S, Fukuyama H, Murai T, Takahashi H.
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142018-e0142018
  • DOI: 10.1371/journal.pone.0142018
  • NAID: 120005743645
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury. (2015)
  • Author(s): Yassin W, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K.
  • Journal Title: J Clin Sleep Med. Volume: 15 Issue: 05 Pages: 581-2
  • DOI: 10.5664/jcsm.4710
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Can we predict switch from unipolar depression to bipolar disorder? (2015)
  • Author(s): Sugihara G, Tajika A.
  • Journal Title: Br J Psychiatry. Volume: 206 Issue: 1 Pages: 79-79
  • DOI: 10.1192/bjp.206.1.79
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Neural basis of cognitive impairments in patients with diffuse axonal injury (2016)
  • Author(s): Ubukata S, Oishi N, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T, Ueda K
  • Organizer: 46th ANNUAL MEETING NEUROSCIENCE 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research