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Protective and risk factors associated with progressive brain alterations in schizophrenia

Research Project

Project/Area Number 15K09825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

Sugihara Genichi  京都大学, 医学研究科, 助教 (70402261)

Co-Investigator(Kenkyū-buntansha) 吉原 雄二郎  京都大学, 医学研究科, 特定助教 (00529464)
大石 直也  京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878)
生方 志浦  京都大学, 医学研究科, 研究員 (40738960)
Research Collaborator NAKAGAMI Yukako  
YOKOYAMA Naoto  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords統合失調症 / 脳画像
Outline of Final Research Achievements

Schizophrenia is a mental disorder which has been linked to subtle brain structural abnormalities. However, such brain abnormalities in schizophrenia vary from person to person. We explored factors which could be associated with individual differences of brain abnormalities in schizophrenia. We found that structural brain abnormalities linked to higher dose of antipsychotic medication, smoking status, and severity of clinical symptoms. We also investigated relationships between autoimmune factors and schizophrenia, but we did not find individuals with schizophrenia who had a specific autoantibody in our sample. Further research is warranted to identify factors which may have protective effects on schizophrenia brains.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial.2018

    • Author(s)
      Nakagami Y, Kubo H, Katsuki R, Sakai T, Sugihara G, Naito C, Oda H, Hayakawa K, Suzuki Y, Fujisawa D, Hashimoto N, Kobara K, Cho T, Kuga H, Takao K, Kawahara Y, Matsumura Y, Murai T, Akashi K, Kanba S, Otsuka K, Kato TA
    • Journal Title

      Journal of Affective Disorders

      Volume: 225 Pages: 569-576

    • DOI

      10.1016/j.jad.2017.08.074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is the prevalence of anti-N-methyl-d-aspartate receptor antibodies in schizophrenia overestimated?2017

    • Author(s)
      Nakagami Y, Sugihara G, Ikeda A, Murai T.
    • Journal Title

      Schizophr Res.

      Volume: S0920-9964 Pages: 30759-4

    • DOI

      10.1016/j.schres.2017.12.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia2017

    • Author(s)
      Yokoyama Naoto、Sasaki Hitoshi、Mori Yasuo、Ono Miki、Tsurumi Kousuke、Kawada Ryosaku、Matsumoto Yukiko、Yoshihara Yujiro、Sugihara Genichi、Miyata Jun、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Schizophr Bull.

      Volume: 1 Pages: 1-10

    • DOI

      10.1093/schbul/sbx092

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-efficacy modulates the neural correlates of craving in male smokers and ex-smokers: an fMRI study2017

    • Author(s)
      Ono Miki、Kochiyama Takanori、Fujino Junya、Sozu Takashi、Kawada Ryosaku、Yokoyama Naoto、Sugihara Genichi、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Addict Biol.

      Volume: 1 Issue: 5 Pages: 1-10

    • DOI

      10.1111/adb.12555

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia.2017

    • Author(s)
      Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
    • Journal Title

      Social Neuroscience

      Volume: Aug 25 Issue: 5 Pages: 1-8

    • DOI

      10.1080/17470919.2017.1366363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Common and differential brain abnormalities in gambling disorder subtypes based on risk attitude.2017

    • Author(s)
      Takeuchi H, Tsurumi K, Murao T, Takemura A, Kawada R, Urayama SI, Aso T,Sugihara GI, Miyata J, Murai T, Takahashi H.
    • Journal Title

      Addictive Behaviors

      Volume: 69 Pages: 48-54

    • DOI

      10.1016/j.addbeh.2017.01.025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach.2016

    • Author(s)
      Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T.
    • Journal Title

      Schizophr Bull.

      Volume: - Pages: 900-906

    • DOI

      10.1093/schbul/sbw176

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Corpus Callosum Pathology as a Potential Surrogate Marker of Cognitive Impairment in Diffuse Axonal Injury.2015

    • Author(s)
      Ubukata S, Ueda K, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T.
    • Journal Title

      J Neuropsychiatry Clin Neurosci.

      Volume: 28 Issue: 2 Pages: 97-103

    • DOI

      10.1176/appi.neuropsych.15070159

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia.2015

    • Author(s)
      Uwatoko T, Yoshizumi M, Miyata J, Ubukata S, Fujiwara H, Kawada R, Kubota M, Sasamoto A, Sugihara G, Aso T, Urayama S, Fukuyama H, Murai T, Takahashi H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 11 Pages: e0142018-e0142018

    • DOI

      10.1371/journal.pone.0142018

    • NAID

      120005743645

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury.2015

    • Author(s)
      Yassin W, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K.
    • Journal Title

      J Clin Sleep Med.

      Volume: 15 Issue: 05 Pages: 581-2

    • DOI

      10.5664/jcsm.4710

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Can we predict switch from unipolar depression to bipolar disorder?2015

    • Author(s)
      Sugihara G, Tajika A.
    • Journal Title

      Br J Psychiatry.

      Volume: 206 Issue: 1 Pages: 79-79

    • DOI

      10.1192/bjp.206.1.79

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Neural basis of cognitive impairments in patients with diffuse axonal injury2016

    • Author(s)
      Ubukata S, Oishi N, Sugihara G, Yassin W, Aso T, Fukuyama H, Murai T, Ueda K
    • Organizer
      46th ANNUAL MEETING NEUROSCIENCE 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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