Elucidation of therapeutic efficacy mechanism of electroconvulsive therapy from the view point of activated glia

• Project/Area Number: 15K09830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Shimane University
• Principal Investigator: HASHIOKA SADAYUKI 島根大学, 医学部, 講師 (00622523)
• Co-Investigator(Kenkyū-buntansha): 津森 登志子 県立広島大学, 保健福祉学部(三原キャンパス), 教授 (30217377)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 電気けいれん療法 / ミクログリア / アストロサイト / Gunnラット / 統合失調症 / グリア

Outline of Final Research Achievements

Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Gunn rats showed schizophrenia-like behavior and depressive-like behavior. In their hippocampus, we found both microgliosis and astrogliosis. Electroconvulsive shock (ECS), the animal model of ECT, ameliorated schizophrenia-like behavior and depressive-like behavior of Gunn rats and attenuated microgliosis and astrogliosis in the hippocampus of Gunn rats. Accordingly, therapeutic effects of ECT may be exerted, at least in part, by inhibition of glial activation.

Research Products

• [Journal Article] Metabolomics analysis implies noninvolvement of the kynurenine pathway neurotoxins in the interferon-β-induced neurotoxicity of adult human astrocytes Neuropsychiatry (2017)
  • Author(s): Hashioka S, Suzuki H, Nakajima D, Miyaoka T, Wake R, Hayashida M, Horiguchi J, Andis Klegeris A
  • Journal Title: Neuropsychiatry Volume: 7(1) Issue: 02 Pages: 610-617
  • DOI: 10.4172/neuropsychiatry.1000192
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat. (2016)
  • Author(s): Limoa E, Hashioka S, Miyaoka T, Tsuchie K, Arauchi R, Azis A I, Wake R, Hayashida M, Araki T, Furuya M, Liaury K, Tanra A J, Horiguchi J
  • Journal Title: Journal of Neuroinflammation Volume: 13(1) Issue: 1 Pages: 230-230
  • DOI: 10.1186/s12974-016-0688-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolomics analysis implies noninvolvement of the kynurenine pathway neurotoxins in the interferon-gamma-induced neurotoxicity of adult human astrocytes (2016)
  • Author(s): Hashioka S, Suzuki H, Nakajima D, Miyaoka T, Wake R, Hayashida M, Horiguchi J, Klegeris A
  • Journal Title: Neuropsychiatry Volume: 7 Pages: 610-617
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Electroconvulsive shock affected the schizophrenia-like behavior and the glial activation in the hippocampus of Gunn rat (2017)
  • Author(s): Erlyn Limoa, Sadayuki Hashioka, Tsuyoshi Miyaoka, Keiko Tsuchie, Ryosuke Arauchi, Rei Wake, Maiko Hayashida, Tomoko Araki, Motohide Furuya, Ilhamuddin, Kristian Liaury, Andi Jayalangkara Tanra, Jun Horiguchi
  • Organizer: The 5th Congress of AsCNP
  • Int'l Joint Research
• [Presentation] Depression-like behaveor in Gunn rats (2017)
  • Author(s): Ilhamuddin A. Azis, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, 三浦章子, 伊豆原宗人, 金山三紗子, Rostia Arianna Abdullah, Erlyn Limoa, 和氣玲, 林田麻衣子, 荒木智子, 古屋智英, Kristian Liaury, Andi J. Tanra, 堀口淳
  • Organizer: 第58回中国・四国精神神経学会
• [Presentation] Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and improved schizophrenia-like behavior of Gunn rat (2016)
  • Author(s): Limoa E, Hashioka S, Miyaoka T, Tsuchie K, Arauchi R, Azis IA, Wake R, Hayashida M, Araki T, Furuya M, Liaury K, Tanra AJ, Horiguchi J
  • Organizer: 中国四国精神神経学会
  • Place of Presentation: 松山（メルパルク松山）
  • Year and Date: 2016-11-10
• [Presentation] Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat (2016)
  • Author(s): Limoa E, Hashioka S, Miyaoka T, Tsuchie K, Arauchi R, Wake R, Hayashida M, Araki T, Furuya M, Azis IA, Liaury K, Tanra AJ, Horiguchi J
  • Organizer: 山陰精神神経学会
  • Place of Presentation: 米子（鳥取大学医学部）
• [Presentation] Electroconvulsive shock ameliorated the schizophrenia-like behavior and altered the expression of CD11b, GFAP and indoleamine 2,3-dioxygenase in the hippocampus of Gunn rat (2015)
  • Author(s): Erlyn Limoa, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, 和氣玲, 林田麻衣子, 荒木智子, Andi J Tanra, 堀口淳
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] The effect of electroconvulsive shock on activated microglia and astrocyte in animal model (2015)
  • Author(s): Erlyn Limoa, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, 和氣玲, 林田麻衣子, 荒木智子, Andi J Tanra, 堀口淳
  • Organizer: 4th Asian Congress of Schizophrenia Research
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Electroconvulsive shock alleviated schizophrenia-like behavior and reduced expression of CD11b and GFAP in the hippocampus of Gunn Rat (2015)
  • Author(s): Erlyn Limoa, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, 和氣玲, 林田麻衣子, 荒木智子, Andi J Tanra, 堀口淳
  • Organizer: 第56回中国・四国精神神経学会
  • Place of Presentation: 倉敷（倉敷市芸文館）
  • Year and Date: 2015-11-12
• [Presentation] Electroconvulsive shock altered schizophrenia-like behavior and glial activation in Gunn rat (2015)
  • Author(s): Erlyn Limoa, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, 和氣玲, 林田麻衣子, 荒木智子, Andi J Tanra, 堀口淳
  • Organizer: 第42回日本脳科学会
  • Place of Presentation: 宮崎（ANAホリディインリゾート宮崎）
  • Year and Date: 2015-11-12