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Neural foundation of resilience in PTSD: A MEG study using subliminal fearful face stimulus

Research Project

Project/Area Number 15K09833
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

Mekawa Toshihiko  九州大学, 医学研究院, 共同研究員 (40448436)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsレジリエンス / PTSD / 自閉症スペクトラム障害 / うつ病 / 扁桃体 / 脳磁図 / 無意識 / 顔認知 / 高機能自閉症 / PTSD
Outline of Final Research Achievements

Amygdala is activated by anxiety and fear. PTSD, depression and ASD are suggested amygdala dysfunction. We hypothesized that fearful faces cause patients with PTSD who have low resilience overresponses of amygdala and cause persons with ASD low amygdala response. MEG can track the neural activities of amygdala with millisecond order. In depression, the resilience scale was sensitive to the symptom of depression and social support maybe a key role of sick recovery course. Regarding ASD,the responses in the left amygdala was weaker than those in the TD group's amygdala under the subliminal experimental condition.Therefore,there may be functional specialization between left and right amygdala.In the supraliminal experimental condition, there were no difference of amygdala responses between ASD and TD groups. Therefore, compensate mechanism can work during awareness process in the ASD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Resilience in the First Episode of Major Depressive Disorder.2017

    • Author(s)
      Maekawa, T., Souda, S., Oyakawa, K., Tanaka, M. and Yamasaki, T
    • Journal Title

      Open Journal of Medical Psychology

      Volume: 6 Issue: 02 Pages: 115-125

    • DOI

      10.4236/ojmp.2017.62009

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Connectopathy in autism spectrum disorders: A review of evidence from visual evoked potentials and diffusion magnetic resonance imaging.2017

    • Author(s)
      Yamasaki T, Maekawa T, Fujita T, Tobimatsu S
    • Journal Title

      Frontiers in Neuroscience

      Volume: 11 Pages: 627-627

    • DOI

      10.3389/fnins.2017.00627

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced fine-form perception does not contribute to gestalt face perception in autism spectrum disorder.2016

    • Author(s)
      Yamasaki, T., Maekawa, T., Miyanaga, Y., Takahashi, K., Takamiya, N., Ogata, K., & Tobimatsu, S.
    • Journal Title

      PLoS One

      Volume: 2:12 Issue: 2 Pages: 1-9

    • DOI

      10.1371/journal.pone.0170239

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuromagnetic evidence that the right fusiform face area is essential for human face awareness: An intermittent binocular rivalry study. (in press)2016

    • Author(s)
      Kume Y, Maekawa T, Urakawa T, Hironaga N, Ogata K, Shigyo M, Tobimatsu S
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 0-0

    • DOI

      10.1016/j.neures.2016.02.004

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemispheric lateralization of face and word recognition in the visual cortices: A high-density ERP study2015

    • Author(s)
      Naomi Takamiya, Toshihiko Maekawa, Katsuya Ogata, et al.
    • Journal Title

      Clinical Neurophysiology

      Volume: 126 Issue: 6 Pages: 62-62

    • DOI

      10.1016/j.clinph.2015.02.051

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatiotemporal dynamics of neuromagnetic oscillations related to the illusory motion perception2015

    • Author(s)
      Akinori Takeda, Toshihiko Maekawa, Katsuya Ogata, et al.
    • Journal Title

      Clinical Neurophysiology

      Volume: 126 Issue: 6 Pages: e55-e55

    • DOI

      10.1016/j.clinph.2015.02.023

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 単耳刺激聴覚定常状態脳磁場反応を用いたてんかん側方性の検討(第一報)2017

    • Author(s)
      松原鉄平,前川敏彦,緒方勝也,飛松省三
    • Organizer
      第40回日本てんかん外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Amygdala responses to subliminal spatial-filtered faces in adults with high-functioning autism spectrum disorder: A MEG study2017

    • Author(s)
      Toshihiko Maekawa, Katsuya Ogata, Takao Yamasaki, Akinori Takeda, Emi Yamada, Teppei Matsubara, Shozo Tobimatsu
    • Organizer
      The 47th European Brain & Behavior Society Meeting (EBBS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered visual perception in autism spectrum disorder2017

    • Author(s)
      Takao Yamasaki, Toshihiko Maekawa, Shozo Tobimatsu
    • Organizer
      The 11th ICME international Conference on Complex Medical Engineering (CME2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amygdala responses to subliminal and supraliminal faces in adults with high function autism spectrum disorder: A MEG study2016

    • Author(s)
      T. Maekawa, K. Ogata, T. Yamasaki, M. Tanaka, S. Tobimatsu
    • Organizer
      Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 逸脱方向に注目した単耳刺激による周波数ミスマッチ脳磁場反応: 予備的検討2016

    • Author(s)
      松原鉄平,前川敏彦,緒方勝也,飛松省三
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島市
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Mismatch negativity and temporal lobe epilepsy2016

    • Author(s)
      Teppei Matsubara, Katsuya Ogata, Toshihiko Maekawa, Nobutaka Mukae, Kimiaki Hashiguchi,Koji Iihara, Shozo Tobimatsu
    • Organizer
      第31回日本脳神経外科国際フォーラム(JNEF)
    • Place of Presentation
      飯塚市
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] レジリエンス尺度を用いたうつ病の回復過程2016

    • Author(s)
      前川敏彦
    • Organizer
      第51回天仁会研究発表会
    • Place of Presentation
      沖縄県那覇市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 視覚誘発電位・事象関連電位2016

    • Author(s)
      前川敏彦
    • Organizer
      第8回沖縄臨床脳波研究会
    • Place of Presentation
      那覇市
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] てんかんを持つひとのメンタルヘルス2016

    • Author(s)
      前川敏彦
    • Organizer
      波の会沖縄県支部&GSK(株)共催 市民公開講座
    • Place of Presentation
      那覇市
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Right hemispheric superiority in the conscious face processing : A high-density ERP study with hemifield stimulation2015

    • Author(s)
      Naomi Takamiya, Toshihiko Maekawa, Katsuya Ogata, et al.
    • Organizer
      SFN2015
    • Place of Presentation
      Washington D.C. USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological correlates of subliminal affective face priming2015

    • Author(s)
      Mutsuhide Tanaka, Toshihiko Maekawa, Katsuya Ogata, et al.
    • Organizer
      SFN2015
    • Place of Presentation
      Washington D.C. USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Clinical application of magnetoencephalography2016

    • Author(s)
      Toshihiko Maekawa, Yuko Oda, Shozo Tobimatsu
    • Total Pages
      330
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] 臨床てんかん学2015

    • Author(s)
      前川敏彦
    • Total Pages
      671
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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