| Project/Area Number |
15K09844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大久保 善朗 日本医科大学, 医学(系)研究科(研究院), 教授 (20213663)
舘野 周 日本医科大学, 医学部, 准教授 (50297917)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アミロイドイメージング / 機能的MRI / デフォルトモード・ネットワーク / 認知症 / 軽度認知障害 / 頭頂葉 / タウイメージング / ポジトロンCT / アミロイド・イメージング / タウ・イメージング / 軽度認知機能障害 / 健常高齢者 / 加齢 |
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| Outline of Final Research Achievements |
Development of new treatments for the early prevention of dementia is a pressing issue for the aging society of Japan. We examined the accumulation of amyloid, considered a risk for dementia, by Positron Emission Tomography. In addition, with the use of functional MRI, we evaluated brain function at resting state in Alzheimer’s disease and depression in the elderly. Based on the results, we verified the associated accumulation of amyloid with brain function at resting state, including the default mode network (DMN). Our results showed that amyloid gradually accumulates in persons at risk of dementia. Further, our results demonstrated that patients with depression have functional impairment in the left parietal lobe, whereas those with Alzheimer’s disease are impaired in the right parietal lobe. From these findings, association between the progressive pathology of dementia and brain function at resting state was revealed.
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