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A prospective study of psychiatric symptoms before and after epilepsy surgery in patients with epilepsy

Research Project

Project/Area Number 15K09851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders

Principal Investigator

Nishida Takuji  独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (00399586)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsてんかん / てんかん外科 / 精神症状 / 精神病 / うつ / 不安
Outline of Final Research Achievements

Psychiatric symptoms such as depression, anxiety and psychosis are common in patients with epilepsy. The pathogenesis of them are not known. In this study, psychiatric evaluation was performed in patients who had epilepsy surgery at the periods of pre-surgical evaluation, 3 months, 1 year, and 2 years after surgery. The psychiatric evaluation was completed in 130 patients at the periods of pre-surgical evaluation and 3 months, 1 year, and 2 years after surgery. Investigation was done in 79 patients with epilepsy surgery who were 16 years of age and older. Thirty two (41%) of 79 patients had psychiatric disorders before or after surgery. Fourteen (67%) of 21 patients who had any psychiatric disorders before surgery showed no psychiatric disorder at the time of 2 years after surgery. Eleven (19%) of 58 patients who had no psychiatric disorders at the pre-surgical evaluation showed any “de novo” psychiatric disorders during the 2 years post-surgical period.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (5 results)

  • [Journal Article] Simple partial status epilepticus presenting with jargon aphasia and focal hyperperfusion demonstrated by ictal pulsed arterial spin labeling MRI2018

    • Author(s)
      Maizuliana H, Ikeda H, Hiyoshi T, Nishida T, Matsuda K, Inoue Y.
    • Journal Title

      Neurology Asia

      Volume: 23 Pages: 77-83

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adjunctive perampanel in partial-onset seizures: Asia-Pacific, randomized phase III study2018

    • Author(s)
      Nishida T, Lee SK, Inoue Y, Saeki K, Ishikawa K, Kaneko S.
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 137 Issue: 4 Pages: 392-399

    • DOI

      10.1111/ane.12883

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of renal function on pharmacokinetics of antiepileptic drugs metabolized by CYP3A4 in a patient with renal impairment2018

    • Author(s)
      Yamamoto Yoshiaki、Usui Naotaka、Nishida Takuji、Mori Miho、Takahashi Yukitoshi、Imai Katsumi、Kagawa Yoshiyuki、Inoue Yushi
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 40 Issue: 1 Pages: 144-147

    • DOI

      10.1097/ftd.0000000000000461

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新世代抗てんかん薬を使いこなす2018

    • Author(s)
      西田拓司
    • Journal Title

      精神医学

      Volume: 60 Pages: 375-384

    • Related Report
      2017 Annual Research Report
  • [Journal Article] てんかん患者学習プログラムMOSES(モーゼス)の有用性に関する予備的調査2018

    • Author(s)
      山﨑陽平, 西田拓司, 井上有史
    • Journal Title

      てんかん研究

      Volume: 35 Pages: 702-709

    • NAID

      130006329230

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients2017

    • Author(s)
      Yamamoto Yoshiaki、Usui Naotaka、Nishida Takuji、Takahashi Yukitoshi、Imai Katsumi、Kagawa Yoshiyuki、Inoue Yushi
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 39 Issue: 4 Pages: 446-449

    • DOI

      10.1097/ftd.0000000000000416

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] てんかんと自動車運転2017

    • Author(s)
      西田拓司
    • Journal Title

      臨床精神医学

      Volume: 46 Pages: 921-928

    • Related Report
      2017 Annual Research Report
  • [Journal Article] てんかん患者の就労支援2017

    • Author(s)
      西田拓司
    • Journal Title

      リハビリテーション医学

      Volume: 54 Pages: 274-278

    • NAID

      130006898783

    • Related Report
      2017 Annual Research Report
  • [Journal Article] てんかんのある人における運転免許の現状と問題点: 2014年道路交通法改正前後の公安委員会・医師へのアンケート調査2017

    • Author(s)
      川合謙介, 荒木敦, 石田重信, 久保田英幹, 菅野秀宣, 太組一朗, 西田拓司, 平田幸一, 前垣義弘, 松浦雅人.
    • Journal Title

      てんかん研究

      Volume: 34 Pages: 637-644

    • NAID

      130006833853

    • Related Report
      2017 Annual Research Report
  • [Journal Article] てんかん患者の認知機能障害に対するリハビリテーションの有用性2016

    • Author(s)
      鈴木健之、西田拓司、井上有史
    • Journal Title

      てんかん研究

      Volume: 34 Pages: 23-30

    • NAID

      130005160645

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] てんかんと合理的配慮2016

    • Author(s)
      西田拓司
    • Journal Title

      Epilepsy

      Volume: 10 Pages: 73-77

    • NAID

      40021019016

    • Related Report
      2016 Research-status Report
  • [Journal Article] てんかんの診断と薬物治療2016

    • Author(s)
      西田拓司
    • Journal Title

      作業療法ジャーナル

      Volume: 50 Pages: 1398-1404

    • Related Report
      2016 Research-status Report
  • [Journal Article] Lamotrigine2015

    • Author(s)
      西田拓司
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 1015-1020

    • Related Report
      2015 Research-status Report
  • [Journal Article] てんかん外科治療前後の生活の質(QOL)の変化2015

    • Author(s)
      中岡健太郎、西田拓司、井上有史
    • Journal Title

      神経内科

      Volume: 82 Pages: 608-611

    • Related Report
      2015 Research-status Report
  • [Presentation] Depression before and after surgery2017

    • Author(s)
      Takuji Nishida, Naotaka Usui, Yushi Inoue.
    • Organizer
      32nd International Epilepsy Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emotional disturbances of people with epilepsy in Japan2017

    • Author(s)
      Takuji Nishida
    • Organizer
      第51回日本てんかん学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] てんかん外科治療前後の精神症状2016

    • Author(s)
      西田拓司
    • Organizer
      第50回日本てんかん学会
    • Place of Presentation
      静岡
    • Related Report
      2016 Research-status Report
  • [Presentation] Depression before and after epilepsy surgery2016

    • Author(s)
      Takuji Nishida
    • Organizer
      ILAE Neuropsychiatry Commission Meeting
    • Place of Presentation
      Aichi
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] てんかんの精神症状を通じて精神病の成り立ちを学ぶ2015

    • Author(s)
      西田拓司
    • Organizer
      第111回日本精神神経学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders2017

    • Author(s)
      Yukitoshi Takahashi, Takuji Nishida, Tomokazu Kimizu, Taikan Oboshi, Asako Horino, Takayoshi Koike, Shinsaku Yoshitomi, Tokito Yamaguchi, Hirowo Omatsu
    • Total Pages
      350
    • Publisher
      Elsevier
    • ISBN
      9780323530880
    • Related Report
      2017 Annual Research Report
  • [Book] プライマリ・ケアのための新規抗てんかん薬マスターブック改訂第2版2017

    • Author(s)
      西田拓司
    • Total Pages
      133
    • Publisher
      診断と治療社
    • ISBN
      9784787823182
    • Related Report
      2017 Annual Research Report
  • [Book] てんかん学用語集2017

    • Author(s)
      西田拓司
    • Total Pages
      165
    • Publisher
      診断と治療社
    • ISBN
      9784787823410
    • Related Report
      2017 Annual Research Report
  • [Book] 今日の精神疾患治療指針第2版2016

    • Author(s)
      西田拓司
    • Total Pages
      1029
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 臨床てんかん学2015

    • Author(s)
      西田拓司
    • Total Pages
      671
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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