| Project/Area Number |
15K09856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 和紀 東北大学, 医学系研究科, 准教授 (40301056)
杉浦 元亮 東北大学, 加齢医学研究所, 教授 (60396546)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Schizophrenia / Self─disturbance / Sense of agency / Forward model / schizophrenia / disturbance of self / delusions of control / forward model / contingency error / prediction error / sensory attenuation / disturbance of the self / delusion of control |
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| Outline of Final Research Achievements |
Self─disturbance is thought to be a highly specific disorder of schizophrenia and is also noted as an index for predicting later onset in psychosis risk state (ARMS). However, a method for objectively evaluating this has not been established yet. In this study, in order to evaluate Self─disturbance, we newly created a task applying the forward model of sensory result collation, and examined it in the patient group and healthy control group. Comparing the brain activity with the condition that the sensory result is different from the prediction and the condition that matches the prediction, the activation was performed in the upper temporal gyrus and Temporo-parietal junction in healthy volunteers, but activation was weak in patients. It is suggested that this result reflects the Self─disturbance and is expected as an indicator of future prognosis of psychosis risk status.
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