Development of a method of specifically predicting the onset of schizophrenia: An fMRI study on self-disturbance

Research Project

Project/Area Number	15K09856
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Psychiatric science
Research Institution	Tohoku University
Principal Investigator	Hiroo Matsuoka 東北大学, 医学系研究科, 教授 (00173815)
Co-Investigator(Kenkyū-buntansha)	松本和紀東北大学, 医学系研究科, 准教授 (40301056) 杉浦元亮東北大学, 加齢医学研究所, 教授 (60396546)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Schizophrenia / Self─disturbance / Sense of agency / Forward model / schizophrenia / disturbance of self / delusions of control / forward model / contingency error / prediction error / sensory attenuation / disturbance of the self / delusion of control
Outline of Final Research Achievements	Self─disturbance is thought to be a highly specific disorder of schizophrenia and is also noted as an index for predicting later onset in psychosis risk state (ARMS). However, a method for objectively evaluating this has not been established yet. In this study, in order to evaluate Self─disturbance, we newly created a task applying the forward model of sensory result collation, and examined it in the patient group and healthy control group. Comparing the brain activity with the condition that the sensory result is different from the prediction and the condition that matches the prediction, the activation was performed in the upper temporal gyrus and Temporo-parietal junction in healthy volunteers, but activation was weak in patients. It is suggested that this result reflects the Self─disturbance and is expected as an indicator of future prognosis of psychosis risk status.