• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research on brain pathological change and identification of predicting factors of developing schizophrenia

Research Project

Project/Area Number 15K09858
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

SUGA MOTOMU  東京大学, 医学部附属病院, 助教 (20553704)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords統合失調症 / 早期精神病 / 生物学的指標 / 脳画像研究 / バイオマーカー / 事象関連電位 / 認知機能 / First Episode Psychosis / At Risk Mental State / MRI / NIRS / 脳構造変化
Outline of Final Research Achievements

We performed neuro-imaging tests including magnetic resonance imaging, electroencephalography, and near infrared spectroscopy. We also conducted neuro-cognitive test battery (Brief Assessment of Cognition in Schizophrenia-Japanese version), and collected blood samples from patients with schizophrenia.
We found that neuro-imaging test especially mismatch negativity calculated from EEG could be a predicting marker, and that BACS scores are candidate markers to improve the determination of diagnosis, severity and clinical stages, especially for schizophrenia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (17 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Associations between daily living skills, cognition, and real-world functioning across stages of schizophrenia; A study with the Schizophrenia Cognition Rating Scale Japanese version.2017

    • Author(s)
      Higuchi Y, Sumiyoshi T, Seo T, Suga M, Takahashia T, Nishiyama S, Komori Y, Kasai K, Suzuki M
    • Journal Title

      Schizophrenia Research Cognition

      Volume: 7 Pages: 13-18

    • DOI

      10.1016/j.scog.2017.01.001

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Duration and frequency mismatch negativity shows no progressive reduction in early stages of psychosis2017

    • Author(s)
      Koshiyama D, Kirihara K, Tada M, Nagai T, Koike S, Suga M, Araki T, Kasai K
    • Journal Title

      Schizophrenia Research

      Volume: 印刷中 Pages: 32-38

    • DOI

      10.1016/j.schres.2017.03.015

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identifying neurocognitive markers for outcome prediction of global functioning in ultra-high-risk for psychosis and first episode psychosis.2017

    • Author(s)
      Sawada K, Kanehara A, Eguchi S, Tada M, Satomura Y, Suga M, Koike S, Kasai K
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 印刷中 Issue: 5 Pages: 318-327

    • DOI

      10.1111/pcn.12522

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis2017

    • Author(s)
      Nagai Tatsuya, Kirihara Kenji, Tada Mariko, Koshiyama Daisuke, Koike Shinsuke, Suga Motomu, Araki Tsuyoshi, Hashimoto Kenji, Kasai Kiyoto
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 2258-2258

    • DOI

      10.1038/s41598-017-02267-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis2017

    • Author(s)
      Koshiyama Daisuke, Kirihara Kenji, Tada Mariko, Nagai Tatsuya, Fujioka Mao, Koike Shinsuke, Suga Motomu, Araki Tsuyoshi, Kasai Kiyoto
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 30607-30607

    • DOI

      10.1016/j.schres.2017.09.045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetoencephalographic recording of auditory mismatch negativity in response to duration and frequency deviants in a single session in patients with schizophrenia.2016

    • Author(s)
      Motomu Suga, Yukika Nishimura, Yuki Kawakubo, Masato Yumoto, Kiyoto Kasai
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 70 Issue: 7 Pages: 295-302

    • DOI

      10.1111/pcn.12397

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins.2016

    • Author(s)
      Yukika Nishimura, Yuki Kawakubo, Motomu Suga, Kenji Hashimoto, Yuichi Takei, Kunio Takei, Hideyuki Inoue, Masato Yumoto, Ryu Takizawa, Kiyoto Kasai
    • Journal Title

      Mol Neuropsychiatry

      Volume: 2(3) Issue: 3 Pages: 161-172

    • DOI

      10.1159/000449426

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: a multi-modal neuroimaging study.2016

    • Author(s)
      Norichika Iwashiro, Shinsuke Koike, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Wataru Gonoi, Ryu Takizawa, Akira Kunimatsu, Hidenori Yamasue, Kiyoto Kasai
    • Journal Title

      Schizophrenia Research

      Volume: Epub ahead of print Issue: 1-3 Pages: 9-15

    • DOI

      10.1016/j.schres.2016.02.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Psychological symptom and social functioning subscales of the modified Global Assessment of Functioning scale: reliability and validity of the Japanese version.2015

    • Author(s)
      Eguchi S, Koike S, Suga M, Takizawa R, Kasai K.
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 69(2) Issue: 2 Pages: 126-127

    • DOI

      10.1111/pcn.12250

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 統合失調症患者に対する臺式簡易客観的精神指標(Utena’s Brief Objective Measures: UBOM)の意義についての研究2018

    • Author(s)
      澤田欣吾、榊原英輔、金原明子、小池春菜、藤枝由美子、管心、宮本有紀、福田正人、笠井清登
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 管心、西村幸香、川久保友紀、湯本真人、笠井清登、統合失調症患者を対象に脳磁計を用いた単一課題中のduration/frequency MMNの測定2017

    • Author(s)
      管心、西村幸香、川久保友紀、湯本真人、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 東京大学医学部附属病院における精神障害者試験的雇用の実践報告2017

    • Author(s)
      清水希実子、塩原裕理、藤枝由美子、飯田美恵、金原明子、管心、芳賀信彦、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] テキストマイニング分析を用いた精神科医療機関への支援要請過程に関する調査2017

    • Author(s)
      太田和佐、谷元子、土屋麻衣子、金原明子、多田真理子、管心、小池進介、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ピアスタッフ導入に向けての取り組み~A病院デイケアでのニーズ調査~2017

    • Author(s)
      藤枝由美子、石橋綾、矢島さやか、清水希美子、管心、金原明子、石浦朋子、宮本有紀、近藤伸介、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 統合失調症患者を対象に脳磁計を用いた単一課題中のduration/frequency MMNの測定2017

    • Author(s)
      管心、西村幸香、川久保友紀、湯本真人、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症の早期段階におけるミスマッチ陰性電位と認知機能・全般的社会適応レベルとの相関解析2017

    • Author(s)
      越山大輔、切原賢治、多田真理子、永井達哉、藤岡真生、小池進介、管心、荒木剛、笠井清登
    • Organizer
      第39回日本生物学的精神医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A病院におけるメタ認知訓練法の効果の検討2017

    • Author(s)
      江口聡、管心、藤枝由美子、夏堀龍暢、山崎修道、笠井清登
    • Organizer
      第12回日本統合失調症学会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] 就学支援におけるアウトリーチと学内ネットワークの構築-A病院精神科デイケアの実践から2016

    • Author(s)
      矢島明佳、塩原裕理、清水希実子、藤枝由美子、管心
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 東京大学医学部附属病院におけるメタ認知訓練法の試み2016

    • Author(s)
      江口聡、山崎修道、夏堀龍暢、吉原美沙紀、管心、笠井清登
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Schizophrenia cognition rating scale Japanese version(SCoRS日本語版)の妥当性に関する研究2016

    • Author(s)
      瀬尾友徳、樋口悠子、住吉太幹、管心、高橋努、西山志満子、水上祐子、鈴木道雄
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 早期精神病に対する機能的アウトカムの予測における神経心理検査の有用性の検討2016

    • Author(s)
      澤田欣吾、松岡潤、永井達哉、里村嘉弘、多田真理子、江口聡、市川絵梨子、下條千恵、管心、小池進介、笠井清登
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] SSTにビデオフィードバックを活用する -発達特性のある当事者の実践から-2016

    • Author(s)
      竹下保稔、藤枝由美子、清水希実子、石橋綾、矢島明佳、石橋明美、高山藍、伊藤哲司、矢野健一、柴田貴美子、管心
    • Organizer
      第21回SST普及集会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Research-status Report
  • [Presentation] 就労準備プログラムによる効果―東大デイホスピタルの実践から―2016

    • Author(s)
      株元麻美、藤枝由美子、石橋綾、清水希実子、矢島明佳、飯田美恵、竹下保稔、管心
    • Organizer
      第24回日本精神障害者リハビリテーション学会
    • Place of Presentation
      長野
    • Related Report
      2016 Research-status Report
  • [Presentation] 通過型デイケアにおける就学支援―東大デイホスピタルの実践から―2015

    • Author(s)
      株元麻美、清水希実子、矢島明佳、江口聡、管心
    • Organizer
      第23回日本精神障害者リハビリテーション学会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
  • [Presentation] SSTでのビデオフィードバックの活用-東大デイホスピタルの実践から-2015

    • Author(s)
      矢島明佳、清水希実子、江口聡、竹下保稔、伊藤哲司、石橋明美、管心
    • Organizer
      第20回SST普及集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] リエゾンアプローチが慢性非特異的腰痛の改善に奏功した統合失調症の一例2015

    • Author(s)
      石橋綾、江口聡、清水希実子、山口正貴、高橋雅人、松平浩、管心
    • Organizer
      第23回日本腰痛学会
    • Place of Presentation
      JPタワーホール&カンファレンス(東京都千代田区)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Book] 公認心理師必携 精神医療・臨床心理の知識と技法2016

    • Author(s)
      管心ら
    • Total Pages
      345
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 精神神経疾患ビジュアルブック2015

    • Author(s)
      管心
    • Total Pages
      325
    • Publisher
      学研
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京大学医学部附属病院精神神経科こころのリスク外来

    • URL

      http://plaza.umin.ac.jp/arms-ut/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi