Research on brain pathological change and identification of predicting factors of developing schizophrenia
| Project/Area Number |
15K09858
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUGA MOTOMU 東京大学, 医学部附属病院, 助教 (20553704)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 統合失調症 / 早期精神病 / 生物学的指標 / 脳画像研究 / バイオマーカー / 事象関連電位 / 認知機能 / First Episode Psychosis / At Risk Mental State / MRI / NIRS / 脳構造変化 |
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| Outline of Final Research Achievements |
We performed neuro-imaging tests including magnetic resonance imaging, electroencephalography, and near infrared spectroscopy. We also conducted neuro-cognitive test battery (Brief Assessment of Cognition in Schizophrenia-Japanese version), and collected blood samples from patients with schizophrenia.
We found that neuro-imaging test especially mismatch negativity calculated from EEG could be a predicting marker, and that BACS scores are candidate markers to improve the determination of diagnosis, severity and clinical stages, especially for schizophrenia.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Associations between daily living skills, cognition, and real-world functioning across stages of schizophrenia; A study with the Schizophrenia Cognition Rating Scale Japanese version.2017
Author(s)
Higuchi Y, Sumiyoshi T, Seo T, Suga M, Takahashia T, Nishiyama S, Komori Y, Kasai K, Suzuki M
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Journal Title
Schizophrenia Research Cognition
Volume: 7
Pages: 13-18
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: a multi-modal neuroimaging study.2016
Author(s)
Norichika Iwashiro, Shinsuke Koike, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Wataru Gonoi, Ryu Takizawa, Akira Kunimatsu, Hidenori Yamasue, Kiyoto Kasai
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Journal Title
Schizophrenia Research
Volume: Epub ahead of print
Issue: 1-3
Pages: 9-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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