Development and Pathogenesis study of the diagnostic marker with sensory impairments in the autism spectrum disorders

• Project/Area Number: 15K09865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Yasuda Yuka 大阪大学, 医学部附属病院, 特任助教(常勤) (20448062)
• Co-Investigator(Kenkyū-buntansha): 山森 英長 大阪大学, 医学系研究科, 講師 (90570250) ; 藤本 美智子 大阪大学, 医学系研究科, 特任助教(常勤) (50647625) ; 藤野 陽生 大阪大学, 人間科学研究科, 招へい研究員 (20707343)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 自閉スペクトラム症 / 診断マーカー / 感覚障害 / 発達障害 / 中間表現型 / 生物学的精神医学

Outline of Final Research Achievements

Sensory processing abnormalities in individuals with autism spectrum disorder (ASD) is included in the latest diagnostic criteria; DSM-5. However, there is no standard method to evaluate sensory abnormalities in individuals with ASD. We compared objective pain sensitivity for 3 different stimuli. Then, we compared both the subjective pain sensitivity assessed by the visual analogue scale (VAS) and the quality of pain assessed by the short form McGill Pain Questionnaire (SF-MPQ) for maximum tolerable pain intensities of each stimulation. The pain detection thresholds and pain tolerances of ASD were not impaired, which suggests that differences do not exist between groups with regard to the somatic perception of pain. However, ASD were significantly hyposensitive with regard to subjective pain intensity and affective aspects of pain sensitivity compared with controls. Our results suggest that the cognitive pathways for pain processing are impaired in ASD.

Research Products

• [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. (2017)
  • Author(s): Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
  • Journal Title: Schizophr Res. Volume: 181 Pages: 75-82
  • DOI: 10.1016/j.schres.2016.10.012
  • NAID: 120007037467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Eye movement as a biomarker of schizophrenia:Using an integrated eye movement score. (2017)
  • Author(s): Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, Hashimoto R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 71(2) Issue: 2 Pages: 104-114
  • DOI: 10.1111/pcn.12460
  • Peer Reviewed / Open Access
• [Journal Article] Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis (2016)
  • Author(s): Setoyama D, Kato TA, Hashimoto R, Kunugi H, Hattori K, Hayakawa K, Sato-Kasai M, Shimokawa N, Kaneko S, Yoshida S, Goto YI, Yasuda Y, Yamamori H, Ohgidani M, Sagata N, Miura D, Kang D, Kanba S
  • Journal Title: PLoS ONE Volume: 11(12) Issue: 12 Pages: e0165267-e0165267
  • DOI: 10.1371/journal.pone.0165267
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. (2016)
  • Author(s): Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R.
  • Journal Title: Psychiatry Res Volume: 245 Pages: 371-378
  • DOI: 10.1016/j.psychres.2016.08.018
  • Peer Reviewed / Open Access
• [Journal Article] Clozapine improved the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with treatment-resistant schizophrenia. (2016)
  • Author(s): Fujimoto M, *Hashimoto R, Yamamori H, Yasuda Y, Ohi K, Iwatani H, Isaka Y, Takeda M.
  • Journal Title: Psychiatry Clin Neurosci Volume: 70 Issue: 10 Pages: 469-469
  • DOI: 10.1111/pcn.12435
  • Peer Reviewed / Open Access
• [Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (2016)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
  • Journal Title: Nat Communications Volume: 7 Issue: 1 Pages: 10594
  • DOI: 10.1038/ncomms10594
  • NAID: 120006535052
  • URL: https://tokushima-u.repo.nii.ac.jp/records/2005585
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study. (2015)
  • Author(s): Yasuda Y, Hashimoto R, Nakae A, Kang H, Ohi K, Yamamori H, Fujimoto M, Hagihira S, Takeda M.
  • Journal Title: Ann Gen Psychiatry. Volume: 15：8 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s12991-016-0095-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. (2015)
  • Author(s): Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 171 Issue: 3 Pages: 447-457
  • DOI: 10.1002/ajmg.b.32426
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2015)
  • Author(s): Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: Journal of Human Genetics Volume: 61 Issue: 3 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • Peer Reviewed / Open Access
• [Journal Article] Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. (2015)
  • Author(s): Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E.
  • Journal Title: BBA Clin Volume: 5 Pages: 101-107
  • DOI: 10.1016/j.bbacli.2016.02.004
  • Peer Reviewed
• [Journal Article] Predicting employment status and subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Journal Title: Schizophrenia Research: Cognition Volume: 3 Pages: 20-25
  • DOI: 10.1016/j.scog.2015.10.005
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanesepopulation. (2015)
  • Author(s): Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R.
  • Journal Title: Neurosci Lett Volume: 612 Pages: 167-171
  • DOI: 10.1016/j.neulet.2015.12.019
  • Peer Reviewed / Open Access
• [Journal Article] Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood. (2015)
  • Author(s): Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K.
  • Journal Title: PLoS One Volume: 24 Issue: 6 Pages: e0127244-e0127244
  • DOI: 10.1371/journal.pone.0127244
  • Peer Reviewed / Open Access
• [Journal Article] グルタミン酸ネットワークが統合失調症の認知機能障害に関与する; 52種類の認知機能の全ゲノム関連研究 (2015)
  • Author(s): 大井一高、橋本亮太、山森英長、安田由華、藤本美智子、武田雅俊
  • Journal Title: 精神医学 Volume: 57 Pages: 1041-1054
  • NAID: 40020682401
• [Journal Article] 統合失調症の認知機能障害の神経科学基盤 (2015)
  • Author(s): 藤野陽生、安田由華、山森英長、藤本美智子、大井一高、福永雅喜、武田雅俊、橋本亮太
  • Journal Title: 臨床精神薬理 Volume: 18 Pages: 1519-1526
• [Journal Article] Imaging Genetics、ゲノム医科学と精神医学 (2015)
  • Author(s): 大井一高、橋本亮太、安田由華、山森英長、藤本美智子、武田雅俊
  • Journal Title: 分子精神医学 Volume: 2
• [Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. (2014)
  • Author(s): Ohi K, Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
  • Journal Title: Schizophr Bull. Volume: 41 Issue: 4 Pages: 909-18
  • DOI: 10.1093/schbul/sbu171
  • NAID: 40020682401
  • Peer Reviewed / Open Access
• [Presentation] The Relationship between cognitive impairment and brain volume in Schizophrenia (2017)
  • Author(s): Yasuda Y, Yamamori H, Kudo N, Azechi H, Fujimoto M, et al.
  • Organizer: the 5th Asian College of Neuropsychopharmacology (AsCNP) Congress 2017
  • Int'l Joint Research
• [Presentation] 統合失調症の認知機能障害の脳構造基盤について (2017)
  • Author(s): 安田由華、福永雅喜、岡田直大、山森英長、越山太輔、工藤紀子、森田健太郎 、畦地裕統、藤本美智子 他
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] ASD-associated de novo mutations in POGZ impair the DNA-binding activity of POGZ. (2016)
  • Author(s): Nakazawa T, Matsumura K, Nagayasu K, Kasai A, Hayata-Takano A, Shintani N, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
  • Organizer: 55th American COllege of Neuropsychopharmacology (ACNP)
  • Place of Presentation: Florida, U.S.A
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] DNA methylation changes in leukocytes by clozapine treatment in patients with treatment-resistant schizophrenia. (2016)
  • Author(s): Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Imoto I, Hashimoto R, Ohmori T.
  • Organizer: Neuroscience 2016 (SfN's 46th annual meeting)
  • Place of Presentation: San Diego, U.S.A
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 統合失調症の皮質下体積と認知・社会機能の相関解析 (2016)
  • Author(s): 越山太輔、福永雅喜、岡田直大、山森英長、安田由華、藤本美智子、山下典生、藤野陽生、渡邉嘉之、住吉チカ、住吉太幹、笠井清登、橋本亮太
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: 群馬
  • Year and Date: 2016-03-25
• [Presentation] ENIGMA-SZJ：統合失調症の皮質下体積のメタアナリシス (2016)
  • Author(s): 岡田直大、福永雅喜、山下典生、越山太輔、山森英長、安田由華、渡邉嘉之、根本清貴、橋本直樹、宮田淳、山末英典、松尾幸治、鬼塚俊明、川崎康弘、吉村玲児、鈴木道雄、武田雅俊、尾崎紀夫、笠井清登、橋本亮太
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: 群馬
  • Year and Date: 2016-03-25
• [Presentation] 統合失調症における補助診断ツールとしての眼球運動スコアの妥当性 (2016)
  • Author(s): 森田健太郎、三浦健一郎、藤本美智子、山森英長、安田由華、笠井清登、橋本亮太
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: 群馬
  • Year and Date: 2016-03-25
• [Presentation] ゲノム科学による霊長類脳の多様性の解明 (2016)
  • Author(s): 橋本亮太、中澤敬信、岡田直大、安田由華、山森英長、松村憲佑、永安一樹、藤本美智子、三浦健一郎、福永雅喜、笠井清登、橋本均
  • Organizer: 平成27年度 京都大学霊長類研究所共同利用研究会「霊長類脳科学の新しい展開とゲノム科学との融合」
  • Place of Presentation: 犬山
  • Year and Date: 2016-03-11
  • Invited
• [Presentation] 長期低栄養で経過した神経性食思不振症のホメオスタシスについて (2016)
  • Author(s): 武田紗織、橋本亮太、安田由華、田中稔久
  • Organizer: 第118回近畿精神神経学会
  • Place of Presentation: 奈良
  • Year and Date: 2016-02-20
• [Presentation] 精神疾患における客観的な補助診断法の最前線、眼球運動を用いた統合失調症の客観的補助診断法 (2015)
  • Author(s): 三浦健一郎、橋本亮太、藤本美智子、山森英長、安田由華、藤野陽生、福永雅喜、武田雅俊
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
  • Invited
• [Presentation] 精神疾患における客観的な補助診断法の最前線、精神疾患における客観的な補助診断法の今後の方向性 (2015)
  • Author(s): 橋本亮太、山森英長、安田由華、藤本美智子、藤野陽生、三浦健一郎、福永雅喜、武田雅俊
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 統合失調症の前頭葉眼窩皮質における脳回パターン解析 (2015)
  • Author(s): 磯村周一、橋本亮太、中村元昭、山下典生、大井一高、山森英長、藤本美智子、安田由華、鬼塚俊明
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 統合失調症における補助診断ツールとしての眼球運動スコアの有用性 (2015)
  • Author(s): 藤本美智子、橋本亮太、三浦健一郎、山森英長、安田由華、大井一高、岩瀬真生、武田雅俊
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 複数のバイオマーカーを用いた統合失調症の補助診断方法確立の検討 (2015)
  • Author(s): 山森英長、橋本亮太、石間環、藤本美智子、安田由華、大井一高、新津富央、沼田周助、大森哲郎、伊豫雅臣、橋本謙二、武田雅俊
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 統合失調の皮質下体積と認知機能の相関解析 (2015)
  • Author(s): 越山太輔、福永雅喜、岡田直大、山下典生、山森英長、安田由華、藤本美智子、大井一高、藤野陽生、笠井清登、橋本亮太
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] ENIGMA-SZJ：統合失調症の皮質下体積のメタアナリシス (2015)
  • Author(s): 岡田直大、福永雅喜、山下典生、越山太輔、山森英長、大井一高、安田由華、藤本美智子、渡邉嘉之、八幡憲明、根本清貴、磯部昌憲、磯村周一、夏堀龍暢、成田尚、橋本直樹、宮田淳、小池進介、高橋努、山末英典、松尾幸治、鬼塚俊明、飯高哲也、吉村玲児、渡邉義文、鈴木道雄、武田雅俊、尾崎紀夫、笠井清登、橋本亮太
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 精神疾患患者における末消血中SHATI/NAT8LのDNAメチル化率の低下 (2015)
  • Author(s): 岩田美奈、宇野恭介、宮崎杜夫、袖山健吾、山森英長、藤本美智子、安田由華、橋本亮太、宮本嘉明、鍋島俊隆、武田雅俊、新田淳美
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] ウエクスラー式知能検査簡略版の開発：機能的転帰との関連 (2015)
  • Author(s): 住吉チカ、藤野陽生、住吉太幹、安田由華、山森英長、大井一高、藤本美智子、橋本亮太、武田雅俊
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] 社会機能は統合失調症患者の主観的QoLを予測する (2015)
  • Author(s): 藤野陽生、住吉チカ、住吉太幹、安田由華、山森英長、大井一高、藤本美智子、橋本亮太、武田雅俊、井村修
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング (2015)
  • Author(s): 松村憲佑、橋本亮太、中澤敬信、鶴崎美徳、安田由華、永安一樹、川島和、山森英長、藤本美智子、大井一高、梅田知美、福永雅喜、藤野陽生、笠井淳司、早田敦子、新谷紀人、武田雅俊、松本直通、橋本均
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Comorbidity of psychiatric disorders in chronic pain. (2015)
  • Author(s): Hashimoto R, Yasuda Y, Nakae A, Yamamori H, Fujimoto M, Ohi K, Kou K, Hagihira S, Miki K, Yukioka M, Takeda M.
  • Organizer: 12th World Congress of Biological Psychiatry 2015
  • Place of Presentation: Athens, Greece
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] Intermediate phenotype strategy for discovering disease related gene network (2015)
  • Author(s): Hashimoto R, Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Fujino H, Watanabe Y, Iwata N, Takeda M.
  • Organizer: 12th World Congress of Biological Psychiatry 2015
  • Place of Presentation: Athens, Greece
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] Predicting social functioning and subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Organizer: WPA regional congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Saliency-guided eye movement during free-viewing in schizophrenic patients. (2015)
  • Author(s): Yoshida M, Miura K, Hashimoto R, Fujimoto M, Yamamori H, Yasuda Y, Ohi K, Fukunaga M, Takeda M, Isa T.
  • Organizer: VCC 2015(Vision science society 2015)
  • Place of Presentation: Florida, U.S.A.
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] The reliability of an integrated eye movement score for biological marker of schizophrenia. (2015)
  • Author(s): Fujimoto M, Hashimoto R, Miura M, Yamamori H, Yasuda Y, Ohi K, Iwase M, Takeda M.
  • Organizer: The Korean Neuropsychiatric Association
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-04-03
  • Int'l Joint Research / Invited
• [Remarks] 大阪大学大学院・医学系研究科・精神医学教室 生物学的精神医学研究グループ
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html
• [Remarks] 大阪大学大学院・医学系研究科・精神医学教室 生物学的精神医学研究グループ
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html
• [Remarks] 分子精神医学研究グループ | 大阪大学精神科 大阪大学大学院医学系研究科精神医学教室
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html