Construction of microcirculation and imaging evaluation method in intractable disease
Project/Area Number |
15K09885
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
TATEISHI Ukihide 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20415524)
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Research Collaborator |
KANO Daisuke 国立研究開発法人 国立がん研究センター東病院, 薬剤部, 試験検査主任 (70392347)
DOI Hisashi 国立研究開発法人理化学研究所, 神戸事業所ライフサイエンス技術基盤研究センター, チームリーダー (00421818)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | Interim / Response / 血管構築 / インテグリン / 画像医学 |
Outline of Final Research Achievements |
Clarification of angiogenetic microcirculation in several subtypes of intractable diseases was tried using integrin-related RGD(Arg-Gly-Asp) peptide imgaing which is known as one of the angiogenetic surrogate markers. This PET probe enabled to evaluate earlier response to BV therapy in solid and non-solid tumor mouse models. As well as RGD peptide, correlation between mitotic activity and salvage TCA cycle metabolic imgaing were compared. There were variety in response to therapy, but response assessment could be performed safely and correctly using interim imaging methods.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] 3. One-month assessment of renal cell carcinoma treated by everolimus using FDG PET/CT predicts progression-free and overall survival.2017
Author(s)
Ito H, Kondo K, Kawahara T, Kaneta T, Tateishi U, Ueno D, Namura K, Kobayashi K, Miyoshi Y, Yumura Y, Makiyama K, Hayashi N, Hasumi H, Osaka K, Yokomizo Y, Teranishi JI, Hattori Y, Inoue T, Uemura H, Yao M, Nakaigawa N.
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Journal Title
Cancer Chemother Pharmacol
Volume: 79
Issue: 5
Pages: 855-861
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The acceleration of glucose accumulation in renal cell carcinoma assessed by FDG PET/CT demonstrated acquisition of resistance to tyrosine kinase inhibitor therapy.2017
Author(s)
Nakaigawa N, Kondo K, Ueno D, Namura K, Makiyama K, Kobayashi K, Shioi K, Ikeda I, Kishida T, Kaneta T, Minamimoto R, Tateishi U, Inoue T, Yao M.
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Journal Title
BMC Cancer.
Volume: 17
Issue: 1
Pages: 39-39
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Infliximab therapy for intestinal, neurological, and vascular involvement in Behcet disease: Efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label, single-arm phase 3 study.2016
Author(s)
Hibi T, Hirohata S, Kikuchi H, Tateishi U, Sato N, Ozaki K, Kondo K, Ishigatsubo Y.
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Journal Title
Medicine (Baltimore)
Volume: 95
Issue: 24
Pages: e3863-e3863
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma.2016
Author(s)
Nakaigawa N, Kondo K, Tateishi U, Minamimoto R, Kaneta T, Namura K, Ueno D, Kobayashi K, Kishida T, Ikeda I, Hasumi H, Makiyama K, Kubota Y, Inoue T, Yao M.
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 67-67
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] (18)F-FDG and (18)F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis2016
Author(s)
Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Hama M, Yoshimi R, Kirino Y, Asami Y, Suda A, Ohno S, Tateishi U, Ueda A, Takeno M, Ishigatsubo Y
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Journal Title
Mod Rheumatol
Volume: 26
Issue: 2
Pages: 180-187
DOI
Related Report
Peer Reviewed
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[Presentation] 肺癌の分子イメージング2015
Author(s)
立石宇貴秀
Organizer
池添メモリアル・胸部画像診断セミナー
Place of Presentation
東京都・品川区・キャノンSタワー
Year and Date
2015-08-01
Related Report
Invited
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