Construction of microcirculation and imaging evaluation method in intractable disease

• Project/Area Number: 15K09885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TATEISHI Ukihide 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20415524)
• Research Collaborator: KANO Daisuke 国立研究開発法人 国立がん研究センター東病院, 薬剤部, 試験検査主任 (70392347) ; DOI Hisashi 国立研究開発法人理化学研究所, 神戸事業所ライフサイエンス技術基盤研究センター, チームリーダー (00421818)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Interim / Response / 血管構築 / インテグリン / 画像医学

Outline of Final Research Achievements

Clarification of angiogenetic microcirculation in several subtypes of intractable diseases was tried using integrin-related RGD(Arg-Gly-Asp) peptide imgaing which is known as one of the angiogenetic surrogate markers. This PET probe enabled to evaluate earlier response to BV therapy in solid and non-solid tumor mouse models. As well as RGD peptide, correlation between mitotic activity and salvage TCA cycle metabolic imgaing were compared. There were variety in response to therapy, but response assessment could be performed safely and correctly using interim imaging methods.

Research Products

• [Journal Article] A simple morphological classification to estimate the malignant potential of pancreatic neuroendocrine tumors (2017)
  • Author(s): Oba Atsushi、Kudo Atsushi、Akahoshi Keiichi、Kishino Mitsuhiro、Akashi Takumi、Katsuta Eriko、Iwao Yasuhito、Ono Hiroaki、Mitsunori Yusuke、Ban Daisuke、Tanaka Shinji、Eishi Yoshinobu、Tateishi Ukihide、Tanabe Minoru
  • Journal Title: Journal of Gastroenterology Volume: 52 Issue: 10 Pages: 1140-1146
  • DOI: 10.1007/s00535-017-1349-7
  • Peer Reviewed
• [Journal Article] 3. One-month assessment of renal cell carcinoma treated by everolimus using FDG PET/CT predicts progression-free and overall survival. (2017)
  • Author(s): Ito H, Kondo K, Kawahara T, Kaneta T, Tateishi U, Ueno D, Namura K, Kobayashi K, Miyoshi Y, Yumura Y, Makiyama K, Hayashi N, Hasumi H, Osaka K, Yokomizo Y, Teranishi JI, Hattori Y, Inoue T, Uemura H, Yao M, Nakaigawa N.
  • Journal Title: Cancer Chemother Pharmacol Volume: ７９ Issue: 5 Pages: 855-861
  • DOI: 10.1007/s00280-017-3275-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The acceleration of glucose accumulation in renal cell carcinoma assessed by FDG PET/CT demonstrated acquisition of resistance to tyrosine kinase inhibitor therapy. (2017)
  • Author(s): Nakaigawa N, Kondo K, Ueno D, Namura K, Makiyama K, Kobayashi K, Shioi K, Ikeda I, Kishida T, Kaneta T, Minamimoto R, Tateishi U, Inoue T, Yao M.
  • Journal Title: BMC Cancer. Volume: １７ Issue: 1 Pages: 39-39
  • DOI: 10.1186/s12885-016-3044-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Infliximab therapy for intestinal, neurological, and vascular involvement in Behcet disease: Efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label, single-arm phase 3 study. (2016)
  • Author(s): Hibi T, Hirohata S, Kikuchi H, Tateishi U, Sato N, Ozaki K, Kondo K, Ishigatsubo Y.
  • Journal Title: Medicine (Baltimore) Volume: 95 Issue: 24 Pages: e3863-e3863
  • DOI: 10.1097/md.0000000000003863
  • Peer Reviewed / Open Access
• [Journal Article] FDG PET/CT as a prognostic biomarker in the era of molecular-targeting therapies: max SUVmax predicts survival of patients with advanced renal cell carcinoma. (2016)
  • Author(s): Nakaigawa N, Kondo K, Tateishi U, Minamimoto R, Kaneta T, Namura K, Ueno D, Kobayashi K, Kishida T, Ikeda I, Hasumi H, Makiyama K, Kubota Y, Inoue T, Yao M.
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s12885-016-2097-4
  • Peer Reviewed / Open Access
• [Journal Article] (18)F-FDG and (18)F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis (2016)
  • Author(s): Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Hama M, Yoshimi R, Kirino Y, Asami Y, Suda A, Ohno S, Tateishi U, Ueda A, Takeno M, Ishigatsubo Y
  • Journal Title: Mod Rheumatol Volume: 26 Issue: 2 Pages: 180-187
  • DOI: 10.3109/14397595.2015.1069458
  • Peer Reviewed
• [Journal Article] Prognostic significance of metabolic tumor burden by positron emission tomography/computed tomography in patients with relapsed/refractory diffuse large B-cell lymphoma (2015)
  • Author(s): Tateishi U, Tatsumi M, Terauchi T, Ando K, Niitsu N, Kim WS, Suh C, Ogura M, Tobinai K
  • Journal Title: Cancer Sci Volume: 106 Issue: 2 Pages: 186-193
  • DOI: 10.1111/cas.12588
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of 18F-fluoride positron emission tomography and magnetic resonance imaging in evaluating early-stage osteoarthritis of the hip (2015)
  • Author(s): Kobayashi N, Inaba Y, Tateishi U, Ike H, Kubota S, Inoue T, Saito T
  • Journal Title: Nucl Med Commun Volume: 36 Issue: 1 Pages: 84-89
  • DOI: 10.1097/mnm.0000000000000214
  • Peer Reviewed
• [Journal Article] Correlation between mechanical stress by finite element analysis and 18F-fluoride PET uptake in hip osteoarthritis patients (2015)
  • Author(s): Hirata Y, Inaba Y, Kobayashi N, Ike H, Yukizawa Y, Fujimaki H, Tezuka T, Tateishi U, Inoue T, Saito T
  • Journal Title: J Orthop Res Volume: 33 Issue: 1 Pages: 78-83
  • DOI: 10.1002/jor.22717
  • Peer Reviewed
• [Presentation] Standardization of FDG-PET/CT for Response Evaluation by RSNA-QIBA Profile: Preliminary Results of a Multicenter Study (2018)
  • Author(s): Hyeyeol Bae, Junichi Tsuchiya, Takehito Okamoto, Ikuko Ito, Yusuke Sonehara, Fumiko Nagahama, Ukihide Tateishi
  • Organizer: 世界核医学会
  • Int'l Joint Research
• [Presentation] Nuclear Medicine (Prostate Cancer Imaging) (2017)
  • Author(s): Tateishi U, Peter Choyke
  • Organizer: Radiologic Society of North America
  • Int'l Joint Research
• [Presentation] 骨軟部腫瘍の画像診断：最新の知見 (2016)
  • Author(s): 立石宇貴秀
  • Organizer: 第89回日本整形外科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-05-13
  • Invited
• [Presentation] 婦人科癌のPET/CT (2016)
  • Author(s): 立石宇貴秀
  • Organizer: 第68回日本産婦人科学会
  • Place of Presentation: 東京国際フォーラム（東京都中央区）
  • Invited
• [Presentation] 肺癌の分子イメージング (2015)
  • Author(s): 立石宇貴秀
  • Organizer: 池添メモリアル・胸部画像診断セミナー
  • Place of Presentation: 東京都・品川区・キャノンSタワー
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] 悪性リンパ腫のPET/CTとLugano分類 (2015)
  • Author(s): 立石宇貴秀
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 北海道・札幌市・ロイトン札幌
  • Year and Date: 2015-07-16
  • Invited