| Project/Area Number |
15K09886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Kitamura Yoji 金沢大学, 学際科学実験センター, 准教授 (10368483)
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| Co-Investigator(Kenkyū-buntansha) |
小川 数馬 金沢大学, 新学術創成研究機構, 准教授 (30347471)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射性医薬品 / ポルフィリン / 金属 / 錯体 / 腫瘍 |
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| Outline of Final Research Achievements |
In this study, a new radiometal-octabromoporphyrines was developed and the possibililty of application for a new tumor imaging agent was examined. As a result, it was found that Octabromotetrakis (4-carboxyphenyl)porphine（OBTCPP） could be very rapidly radiolabelled by 111In, a radio nuclear for diagnosis. It was also found that, in tumor bearing mice transplanted colon26 tumor cell, 111In-OBTCPP was accumulated in the tumor at about 5%ID/g, and tumor to muscle ratio was over 10. Furthermore, in SPECT-CT imaging study, the image acquired 24 h after injection reflected bio-distribution study, and the tumor was visualized. In conclusion, 111In-OBTCPP has possibility of application for a new tumor imaging agent.
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